Core Binding Factor beta Subunit
"Core Binding Factor beta Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-DNA binding transcription factor that is a subunit of core binding factor. It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
| Descriptor ID |
D050658
|
| MeSH Number(s) |
D12.776.930.155.400
|
| Concept/Terms |
Core Binding Factor beta Subunit- Core Binding Factor beta Subunit
- Core Binding Factor beta
- Polyomavirus Enhancer Binding Protein 2, beta Subunit
- CBFB Protein
- Core Binding Factor beta Protein
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor beta Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor beta Subunit".
This graph shows the total number of publications written about "Core Binding Factor beta Subunit" by people in this website by year, and whether "Core Binding Factor beta Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Core Binding Factor beta Subunit" by people in Profiles.
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Downregulation of RUNX1/CBFß by MLL fusion proteins enhances hematopoietic stem cell self-renewal. Blood. 2014 Mar 13; 123(11):1729-38.
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The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood. 2011 Dec 15; 118(25):6544-52.
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Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16). Cancer Res. 2007 Feb 01; 67(3):992-1000.
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Coexistence of inversion 16 and the Philadelphia chromosome in acute and chronic myeloid leukemias : report of six cases and review of literature. Am J Clin Pathol. 2006 Feb; 125(2):260-6.