An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.

Descriptor ID	D015776
MeSH Number(s)	C16.320.850.475.440 C17.800.428.435.440 C17.800.827.475.440
Concept/Terms	Keratoderma, Palmoplantar, Diffuse Keratoderma, Palmoplantar, Diffuse Unna-Thost Syndrome Syndrome, Unna-Thost Unna Thost Syndrome Tylosis Thost-Unna Syndrome Syndrome, Thost-Unna Thost Unna Syndrome Keratosis Palmaris et Plantaris Familiaris Keratosis Palmaris et Plantaris Familiaris

Below are MeSH descriptors whose meaning is more general than "Keratoderma, Palmoplantar, Diffuse".

Below are MeSH descriptors whose meaning is related to "Keratoderma, Palmoplantar, Diffuse".

Below are MeSH descriptors whose meaning is more specific than "Keratoderma, Palmoplantar, Diffuse".