"Decorin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.
| Descriptor ID |
D058575
|
| MeSH Number(s) |
D09.698.735.700.750 D12.776.395.650.750.625 D12.776.395.650.875.500 D12.776.860.300.806.750
|
| Concept/Terms |
Decorin- Decorin
- Bone Proteoglycan II
- Proteoglycan II, Bone
- DSPG-II
|
Below are MeSH descriptors whose meaning is more general than "Decorin".
Below are MeSH descriptors whose meaning is more specific than "Decorin".
This graph shows the total number of publications written about "Decorin" by people in this website by year, and whether "Decorin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Decorin" by people in Profiles.
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The extracellular matrix differentially directs myoblast motility and differentiation in distinct forms of muscular dystrophy: Dystrophic matrices alter myoblast motility. Matrix Biol. 2024 May; 129:44-58.
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Systemic Delivery of an Oncolytic Adenovirus Expressing Decorin for the Treatment of Breast Cancer Bone Metastases. Hum Gene Ther. 2015 Dec; 26(12):813-25.
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The systemic delivery of an oncolytic adenovirus expressing decorin inhibits bone metastasis in a mouse model of human prostate cancer. Gene Ther. 2015 Mar; 22(3):247-56.
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TGFbeta neutralization within cardiac allografts by decorin gene transfer attenuates chronic rejection. J Immunol. 2009 Dec 01; 183(11):7307-13.
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Evidence for a proinflammatory and proteolytic environment in plaques from endarterectomy segments of human carotid arteries. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):129-35.
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In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer. FASEB J. 2003 Mar; 17(3):464-6.
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Proteoglycan gene expression is decreased in abdominal aortic aneurysms. J Surg Res. 1998 Jan; 74(1):76-80.