Neural Cell Adhesion Molecule L1
"Neural Cell Adhesion Molecule L1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
| Descriptor ID |
D039842
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| MeSH Number(s) |
D12.776.395.550.200.250.520.578 D12.776.543.550.200.250.520.578 D23.050.301.350.250.520.578
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| Concept/Terms |
Neural Cell Adhesion Molecule L1- Neural Cell Adhesion Molecule L1
- NILE Glycoprotein
- Glycoprotein, NILE
- Nerve Growth Factor-Inducible Large External Glycoprotein
- Nerve Growth Factor Inducible Large External Glycoprotein
- CALL Protein
- CamL1 Gene Product
- Neural Adhesion Molecule L1
- L1 Cell Adhesion Molecule
- L1CAM
- NILE Protein
- Cell Adhesion Molecule L1
- Cell Surface Glycoprotein L1
- NGF-Inducible Glycoprotein
- Glycoprotein, NGF-Inducible
- NGF Inducible Glycoprotein
- F11 Glycoprotein
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This graph shows the total number of publications written about "Neural Cell Adhesion Molecule L1" by people in this website by year, and whether "Neural Cell Adhesion Molecule L1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Neural Cell Adhesion Molecule L1" by people in Profiles.
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Preclinical Assessment of CD171-Directed CAR T-cell Adoptive Therapy for Childhood Neuroblastoma: CE7 Epitope Target Safety and Product Manufacturing Feasibility. Clin Cancer Res. 2017 Jan 15; 23(2):466-477.
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Noggin expands neural stem cells in the adult hippocampus. J Neurosci. 2008 Sep 10; 28(37):9194-204.
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Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther. 2007 Apr; 15(4):825-33.
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Activation of cell-survival transcription factor NFkappaB in L1Ig6-stimulated endothelial cells. J Biomed Mater Res A. 2006 Jun 01; 77(3):542-50.
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Neurite extension and in vitro myelination within three-dimensional modified fibrin matrices. J Neurobiol. 2005 Apr; 63(1):1-14.
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Mechanical properties, proteolytic degradability and biological modifications affect angiogenic process extension into native and modified fibrin matrices in vitro. Biomaterials. 2005 Apr; 26(12):1369-79.
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Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Microvasc Res. 2004 Nov; 68(3):169-78.
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Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis. 2004; 7(3):213-23.
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Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases. J Biol Chem. 1998 May 22; 273(21):13223-9.