"ORAI1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The pore-forming subunit of calcium release activated calcium channels. It is activated by STROMAL INTERACTION MOLECULE 1 upon intracellular calcium depletion.
| Descriptor ID |
D000071740
|
| MeSH Number(s) |
D12.776.157.530.400.150.740.500 D12.776.543.550.450.150.740.500 D12.776.543.585.400.150.740.500
|
| Concept/Terms |
ORAI1 Protein- ORAI1 Protein
- Calcium Release-Activated Calcium Channel Protein 1
- Calcium Release Activated Calcium Channel Protein 1
- ORAI Calcium Release-Activated Calcium Modulator 1
- ORAI Calcium Release Activated Calcium Modulator 1
|
Below are MeSH descriptors whose meaning is more general than "ORAI1 Protein".
Below are MeSH descriptors whose meaning is more specific than "ORAI1 Protein".
This graph shows the total number of publications written about "ORAI1 Protein" by people in this website by year, and whether "ORAI1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "ORAI1 Protein" by people in Profiles.
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STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells. EMBO Mol Med. 2020 08 07; 12(8):e11592.
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Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function. J Clin Invest. 2016 11 01; 126(11):4303-4318.
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Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803.
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Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells. J Immunol. 2015 Aug 01; 195(3):1202-17.
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Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease ß-amyloid peptide secretion. J Biol Chem. 2013 Sep 13; 288(37):26955-66.
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Chronic exposure to stress hormones alters the subtype of store-operated channels expressed in H19-7 hippocampal neuronal cells. J Cell Physiol. 2013 Jun; 228(6):1332-43.
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ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations. PLoS One. 2012; 7(1):e29387.
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Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol. 2011 Sep; 31(17):3546-56.
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Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Mol Cell Biol. 2011 Sep; 31(17):3531-45.