"DNA Topoisomerases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.
| Descriptor ID |
D026942
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| MeSH Number(s) |
D08.811.399.403
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases".
This graph shows the total number of publications written about "DNA Topoisomerases" by people in this website by year, and whether "DNA Topoisomerases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Topoisomerases" by people in Profiles.
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Purification of Saccharomyces cerevisiae Homologous Recombination Proteins Dmc1 and Rdh54/Tid1 and a Fluorescent D-Loop Assay. Methods Enzymol. 2018; 600:307-320.
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Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth. Mol Cell. 2010 Sep 24; 39(6):862-72.
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The broken genome: genetic and pharmacologic approaches to breaking DNA. Ann Med. 2007; 39(3):208-18.
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Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin. Genes Dev. 2006 Sep 15; 20(18):2593-604.
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Crossover interference in Saccharomyces cerevisiae requires a TID1/RDH54- and DMC1-dependent pathway. Genetics. 2003 Apr; 163(4):1273-86.