Christopher Froelich to Apoptosis
This is a "connection" page, showing publications Christopher Froelich has written about Apoptosis.
Connection Strength
2.419
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Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes. Cell Death Differ. 2015 Jan; 22(1):74-85.
Score: 0.299
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Granzyme B-mediated apoptosis--the elephant and the blind men? Cell Death Differ. 2004 Apr; 11(4):369-71.
Score: 0.146
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Right place, right time. Nat Immunol. 2004 Feb; 5(2):124-5.
Score: 0.144
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Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism. Curr Opin Immunol. 2003 Oct; 15(5):528-32.
Score: 0.141
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Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis. J Cell Biol. 2003 Mar 17; 160(6):875-85.
Score: 0.135
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Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. J Biol Chem. 2002 Dec 20; 277(51):49523-30.
Score: 0.132
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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Immunity. 2002 Mar; 16(3):417-28.
Score: 0.126
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Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. J Immunol. 1999 May 01; 162(9):5345-50.
Score: 0.104
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Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases. Immunol Today. 1998 Jan; 19(1):30-6.
Score: 0.095
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Granule-mediated killing: pathways for granzyme B-initiated apoptosis. J Exp Med. 1997 Oct 20; 186(8):1323-31.
Score: 0.093
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New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem. 1996 Nov 15; 271(46):29073-9.
Score: 0.087
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Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun. 1996 Oct 23; 227(3):658-65.
Score: 0.087
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Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion. J Biol Chem. 2015 Mar 13; 290(11):6868-77.
Score: 0.077
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Perforin rapidly induces plasma membrane phospholipid flip-flop. PLoS One. 2011; 6(9):e24286.
Score: 0.061
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Granzyme A is a proinflammatory protease. Blood. 2009 Oct 29; 114(18):3968; author reply 3969-70.
Score: 0.054
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Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells. PLoS One. 2008 Sep 01; 3(9):e3102.
Score: 0.049
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Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events. J Biol Chem. 2004 May 21; 279(21):22020-9.
Score: 0.036
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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J Cell Biol. 2003 Jan 20; 160(2):223-33.
Score: 0.034
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Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. J Leukoc Biol. 2002 Oct; 72(4):668-76.
Score: 0.033
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HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas. J Immunol. 2001 Oct 01; 167(7):3928-35.
Score: 0.031
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The T cell death knell: immune-mediated tumor death in renal cell carcinoma. Clin Cancer Res. 2001 Oct; 7(10):3276-81.
Score: 0.031
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A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol. 2001 Jul 01; 167(1):350-6.
Score: 0.030
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Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells. Cancer Immunol Immunother. 2001 Jun; 50(4):212-7.
Score: 0.030
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Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis. Cancer Res. 2001 Jan 01; 61(1):348-54.
Score: 0.029
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Cell death-associated translocation of plasma membrane components induced by CTL. J Immunol. 2000 May 01; 164(9):4641-8.
Score: 0.028
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Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis. Exp Cell Res. 2000 Mar 15; 255(2):144-55.
Score: 0.028
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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol. 1999 Dec; 19(12):8604-15.
Score: 0.027
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BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis. J Biol Chem. 1999 Feb 12; 274(7):3953-61.
Score: 0.026
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FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. J Immunol. 1998 Oct 15; 161(8):3936-42.
Score: 0.025
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Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 1998 Aug 01; 92(3):1044-54.
Score: 0.025
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Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Cell Death Differ. 1998 Jun; 5(6):488-96.
Score: 0.024
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The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells. Immunology. 1998 Mar; 93(3):383-9.
Score: 0.024
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Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole cell cytotoxicity assays. Biochem Biophys Res Commun. 1996 Dec 04; 229(1):44-9.
Score: 0.022
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The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem. 1996 Jul 12; 271(28):16443-6.
Score: 0.021
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Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Curr Biol. 1996 Jul 01; 6(7):897-9.
Score: 0.021
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Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics. J Biol Chem. 2010 Jun 11; 285(24):18918-27.
Score: 0.014
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A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells. J Biol Chem. 2005 May 27; 280(21):20752-61.
Score: 0.010
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A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis. J Immunol. 2004 Sep 15; 173(6):3801-9.
Score: 0.009
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Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells. J Biol Chem. 2004 May 07; 279(19):20200-10.
Score: 0.009
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Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem. 1998 Dec 18; 273(51):34278-83.
Score: 0.006
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Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem. 1998 Oct 16; 273(42):27084-90.
Score: 0.006
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Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus. Cell Immunol. 1997 Aug 25; 180(1):1-9.
Score: 0.006
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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996 Jul 12; 271(28):16720-4.
Score: 0.005