David Grdina to Amifostine
This is a "connection" page, showing publications David Grdina has written about Amifostine.
Connection Strength
4.151
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Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. Int J Radiat Oncol Biol Phys. 2009 Mar 01; 73(3):886-96.
Score: 0.293
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Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiat Res. 2008 May; 169(5):495-505.
Score: 0.277
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Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs. Radiat Res. 2007 Jul; 168(1):106-14.
Score: 0.261
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Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice. Semin Oncol. 2002 Dec; 29(6 Suppl 19):22-8.
Score: 0.190
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Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine. Int J Radiat Oncol Biol Phys. 2002 May 01; 53(1):180-9.
Score: 0.183
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Inhibition of spontaneous metastases formation by amifostine. Int J Cancer. 2002 Jan 10; 97(2):135-41.
Score: 0.179
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Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells. Semin Radiat Oncol. 2002 Jan; 12(1 Suppl 1):103-11.
Score: 0.179
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Radioprotectants: current status and new directions. Oncology. 2002; 63 Suppl 2:2-10.
Score: 0.179
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Amifostine: mechanisms of action underlying cytoprotection and chemoprevention. Drug Metabol Drug Interact. 2000; 16(4):237-79.
Score: 0.155
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Chemopreventive doses of amifostine confer no cytoprotection to tumor nodules growing in the lungs of mice treated with cyclophosphamide. Semin Oncol. 1999 Apr; 26(2 Suppl 7):22-7.
Score: 0.148
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Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine. Carcinogenesis. 1997 Dec; 18(12):2457-9.
Score: 0.135
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WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun-Jul; 30(6-7):283-94.
Score: 0.130
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Antimutagenic effects of amifostine: clinical implications. Semin Oncol. 1996 Aug; 23(4 Suppl 8):53-7.
Score: 0.123
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Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Carcinogenesis. 1995 Apr; 16(4):767-74.
Score: 0.112
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Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. Radiat Res. 2014 May; 181(5):464-70.
Score: 0.105
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Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent. Cell Biol Toxicol. 2014 Feb; 30(1):55-66.
Score: 0.103
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The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation. Carcinogenesis. 1992 May; 13(5):811-4.
Score: 0.091
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In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis. Int J Radiat Biol. 1992 May; 61(5):567-76.
Score: 0.091
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Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice. Int J Radiat Biol. 1992 Mar; 61(3):387-92.
Score: 0.090
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Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons. Adv Space Res. 1992; 12(2-3):257-63.
Score: 0.089
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Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit Care Med. 2011 Dec; 39(12):2711-21.
Score: 0.089
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SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free Radic Biol Med. 2011 Nov 15; 51(10):1918-25.
Score: 0.087
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Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid. Cancer Res. 1991 Aug 15; 51(16):4125-30.
Score: 0.087
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Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiat Res. 2010 Feb; 173(2):175-83.
Score: 0.078
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Amifostine reduces lung vascular permeability via suppression of inflammatory signalling. Eur Respir J. 2009 Mar; 33(3):612-24.
Score: 0.072
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WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radic Biol Med. 2008 Dec 15; 45(12):1674-81.
Score: 0.071
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Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. Int J Radiat Biol. 2008 Aug; 84(8):623-34.
Score: 0.070
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Radiation-induced DNA single-strand breaks in the intestinal mucosal cells of mice treated with the radioprotectors WR-2721 or 16-16 dimethyl prostaglandin E2. Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Jul; 52(1):67-76.
Score: 0.065
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Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha. Radiat Res. 2007 Apr; 167(4):465-74.
Score: 0.064
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Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with gamma-radiation within one day after birth. Cancer Res. 1985 Nov; 45(11 Pt 1):5379-81.
Score: 0.058
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Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Radiat Res. 2004 Nov; 162(5):536-46.
Score: 0.054
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Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC). Int J Radiat Oncol Biol Phys. 2004 Oct 01; 60(2):553-63.
Score: 0.054
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Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo. Biochim Biophys Acta. 2003 Mar 20; 1637(2):151-5.
Score: 0.049
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Relationships between cytoprotection and mutation prevention by WR-1065. Mil Med. 2002 Feb; 167(2 Suppl):51-3.
Score: 0.045
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Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines. Int J Radiat Biol. 2000 May; 76(5):633-9.
Score: 0.040
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Misoprostol, a PGE1 analog, protects mice from fission-neutron injury. Radiat Res. 1991 Oct; 128(1 Suppl):S12-7.
Score: 0.022
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Radioprotectors in treatment therapy to reduce risk in secondary tumor induction. Pharmacol Ther. 1988; 39(1-3):21-5.
Score: 0.017
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A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327. Radiat Res. 1986 May; 106(2):224-33.
Score: 0.015