"Amifostine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
| Descriptor ID |
D004999
|
| MeSH Number(s) |
D02.705.400.625.050 D02.705.539.345.050 D02.886.300.692.050
|
| Concept/Terms |
Amifostine- Amifostine
- Amifostine Trihydrate
- Trihydrate, Amifostine
- APAETP
|
Below are MeSH descriptors whose meaning is more general than "Amifostine".
Below are MeSH descriptors whose meaning is more specific than "Amifostine".
This graph shows the total number of publications written about "Amifostine" by people in this website by year, and whether "Amifostine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1997 | 2 | 0 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 2 | 3 |
| 2002 | 5 | 1 | 6 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 2 | 3 |
| 2007 | 1 | 1 | 2 |
| 2008 | 4 | 0 | 4 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 1 | 2 |
| 2014 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amifostine" by people in Profiles.
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Amifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism. Eur J Med Res. 2024 Jan 20; 29(1):68.
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Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. Radiat Res. 2014 May; 181(5):464-70.
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Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent. Cell Biol Toxicol. 2014 Feb; 30(1):55-66.
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Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit Care Med. 2011 Dec; 39(12):2711-21.
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SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free Radic Biol Med. 2011 Nov 15; 51(10):1918-25.
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A Phase I trial: dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection. Biol Blood Marrow Transplant. 2011 Jul; 17(7):1033-42.
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Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiat Res. 2010 Feb; 173(2):175-83.
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Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. Int J Radiat Oncol Biol Phys. 2009 Mar 01; 73(3):886-96.
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Amifostine reduces lung vascular permeability via suppression of inflammatory signalling. Eur Respir J. 2009 Mar; 33(3):612-24.
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WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radic Biol Med. 2008 Dec 15; 45(12):1674-81.