Stephen Archer to Rats
This is a "connection" page, showing publications Stephen Archer has written about Rats.
Connection Strength
3.054
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Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis. Circ Res. 2020 06 05; 126(12):1723-1745.
Score: 0.116
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Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020 01; 34(1):1447-1464.
Score: 0.113
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Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease. Circ Res. 2019 08 02; 125(4):449-466.
Score: 0.109
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Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities. Int J Mol Sci. 2018 Sep 12; 19(9).
Score: 0.104
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MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype. Am J Respir Crit Care Med. 2017 Feb 15; 195(4):515-529.
Score: 0.093
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Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension. Circulation. 2015 May 12; 131(19):1691-702.
Score: 0.083
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Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. J Mol Med (Berl). 2013 Oct; 91(10):1185-97.
Score: 0.072
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PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78.
Score: 0.072
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Rodent models of group 1 pulmonary hypertension. Handb Exp Pharmacol. 2013; 218:105-49.
Score: 0.070
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FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl). 2013 Mar; 91(3):333-46.
Score: 0.070
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GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Circulation. 2012 Dec 11; 126(24):2859-69.
Score: 0.069
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Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res. 2012 May 25; 110(11):1484-97.
Score: 0.067
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Lung ยน8F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 Mar 15; 185(6):670-9.
Score: 0.066
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Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle. J Mol Med (Berl). 2012 Jan; 90(1):31-43.
Score: 0.064
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Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH. Int J Clin Pract Suppl. 2011 Aug; (172):15-34.
Score: 0.064
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A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):1080-91.
Score: 0.061
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Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2010 Sep; 299(3):L401-12.
Score: 0.059
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Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation. 2010 Jun 22; 121(24):2661-71.
Score: 0.059
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A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension. Adv Exp Med Biol. 2010; 661:171-85.
Score: 0.057
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The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. J Mol Med (Berl). 2010 Jan; 88(1):47-60.
Score: 0.057
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Pathways of proliferation: new targets to inhibit the growth of vascular smooth muscle cells. Circ Res. 2008 Nov 07; 103(10):1047-9.
Score: 0.053
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Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H570-8.
Score: 0.049
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Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L933-40.
Score: 0.048
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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007 Jan; 11(1):37-51.
Score: 0.046
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Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2007 Apr; 292(4):L872-8.
Score: 0.046
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The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels. FASEB J. 2004 Sep; 18(12):1382-91.
Score: 0.039
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Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ Res. 2004 Aug 06; 95(3):308-18.
Score: 0.039
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Multi-omic and multispecies analysis of right ventricular dysfunction. J Heart Lung Transplant. 2024 Feb; 43(2):303-313.
Score: 0.037
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The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies. Adv Exp Med Biol. 2003; 543:293-322.
Score: 0.035
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Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2022 09 01; 206(5):608-624.
Score: 0.034
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Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ Res. 2002 Jun 28; 90(12):1307-15.
Score: 0.034
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Inhibiting pyruvate kinase muscle isoform 2 regresses group 2 pulmonary hypertension induced by supra-coronary aortic banding. Acta Physiol (Oxf). 2022 02; 234(2):e13764.
Score: 0.033
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Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation. 2002 Jan 15; 105(2):244-50.
Score: 0.033
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Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility. Circ Heart Fail. 2022 01; 15(1):e008574.
Score: 0.033
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Potassium channels regulate tone in rat pulmonary veins. Am J Physiol Lung Cell Mol Physiol. 2001 Jun; 280(6):L1138-47.
Score: 0.031
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Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol (1985). 2001 Jun; 90(6):2249-56.
Score: 0.031
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Gene transfer and metabolic modulators as new therapies for pulmonary hypertension. Increasing expression and activity of potassium channels in rat and human models. Adv Exp Med Biol. 2001; 502:401-18.
Score: 0.031
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Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension. Int J Mol Sci. 2020 Oct 01; 21(19).
Score: 0.030
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Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension. Circulation. 2020 10 13; 142(15):1464-1484.
Score: 0.030
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Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion. Acta Physiol (Oxf). 2020 08; 229(4):e13483.
Score: 0.029
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Dexfenfluramine elevates systemic blood pressure by inhibiting potassium currents in vascular smooth muscle cells. J Pharmacol Exp Ther. 1999 Dec; 291(3):1143-9.
Score: 0.028
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Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. Circ Res. 2019 06 07; 124(12):1727-1746.
Score: 0.027
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Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat. J Vis Exp. 2018 11 18; (141).
Score: 0.026
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A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension. Chest. 1998 Sep; 114(3 Suppl):200S-204S.
Score: 0.026
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Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J Clin Invest. 1998 Jun 01; 101(11):2319-30.
Score: 0.026
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Utility of a nitric oxide electrode for monitoring the administration of nitric oxide in biologic systems. J Lab Clin Med. 1998 Mar; 131(3):281-5.
Score: 0.025
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Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications. Circulation. 2018 07 17; 138(3):287-304.
Score: 0.025
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Diversity of response in vascular smooth muscle cells to changes in oxygen tension. Kidney Int. 1997 Feb; 51(2):462-6.
Score: 0.023
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Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation. 1996 Nov 01; 94(9):2216-20.
Score: 0.023
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Chronic infusion of nitric oxide in experimental pulmonary hypertension: pulmonary pressure-flow analysis. Eur Respir J. 1996 Jul; 9(7):1475-81.
Score: 0.022
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Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ Res. 1996 Mar; 78(3):431-42.
Score: 0.022
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Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension. Cardiovasc Res. 1996 Jan; 31(1):55-62.
Score: 0.022
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Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue. Exp Physiol. 1995 Sep; 80(5):825-34.
Score: 0.021
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Effect of graded hypoxia on the induction and function of inducible nitric oxide synthase in rat mesangial cells. Circ Res. 1995 Jul; 77(1):21-8.
Score: 0.021
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Dithionite increases radical formation and decreases vasoconstriction in the lung. Evidence that dithionite does not mimic alveolar hypoxia. Circ Res. 1995 Jul; 77(1):174-81.
Score: 0.021
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Activation of the cGMP-dependent protein kinase mimics the stimulatory effect of nitric oxide and cGMP on calcium-gated potassium channels. Physiol Res. 1995; 44(1):39-44.
Score: 0.020
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Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7583-7.
Score: 0.020
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Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats. J Appl Physiol (1985). 1994 Feb; 76(2):933-40.
Score: 0.019
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A redox-based O2 sensor in rat pulmonary vasculature. Circ Res. 1993 Dec; 73(6):1100-12.
Score: 0.019
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NG-monomethyl-L-arginine causes nitric oxide synthesis in isolated arterial rings: trouble in paradise. Biochem Biophys Res Commun. 1992 Oct 30; 188(2):590-6.
Score: 0.017
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Measurement of endothelial cytosolic calcium concentration and nitric oxide production reveals discrete mechanisms of endothelium-dependent pulmonary vasodilatation. Circ Res. 1991 Jun; 68(6):1569-81.
Score: 0.016
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Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation. 2011 May 17; 123(19):2120-31.
Score: 0.016
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The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner. J Physiol. 2010 Jul 15; 588(Pt 14):2657-68.
Score: 0.015
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Comparison of the hemodynamic effects of nitric oxide and endothelium-dependent vasodilators in intact lungs. J Appl Physiol (1985). 1990 Feb; 68(2):735-47.
Score: 0.014
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Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem Biophys Res Commun. 1989 Nov 15; 164(3):1198-205.
Score: 0.014
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Simultaneous measurement of O2 radicals and pulmonary vascular reactivity in rat lung. J Appl Physiol (1985). 1989 Nov; 67(5):1903-11.
Score: 0.014
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Detection of activated O2 species in vitro and in rat lungs by chemiluminescence. J Appl Physiol (1985). 1989 Nov; 67(5):1912-21.
Score: 0.014
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Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med. 2009 Dec 01; 180(11):1131-42.
Score: 0.014
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Effect of dietary fish oil on lung lipid profile and hypoxic pulmonary hypertension. J Appl Physiol (1985). 1989 Apr; 66(4):1662-73.
Score: 0.014
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Hypoxic pulmonary vasoconstriction is unaltered by creatine depletion induced by dietary beta-guanidino propionic acid. Life Sci. 1989; 45(12):1081-8.
Score: 0.013
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Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung. J Appl Physiol (1985). 1989 Jan; 66(1):102-11.
Score: 0.013
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Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung disease. Am J Respir Crit Care Med. 2008 Aug 15; 178(4):399-406.
Score: 0.013
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Effects of dietary fish oil on lung phospholipid fatty acid composition and intrinsic pulmonary vascular reactivity. Cardiovasc Res. 1987 Dec; 21(12):928-32.
Score: 0.012
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Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation. 2007 Jul 17; 116(3):238-48.
Score: 0.012
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The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A. 2007 Jul 03; 104(27):11418-23.
Score: 0.012
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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation. 2006 Jun 06; 113(22):2630-41.
Score: 0.011
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Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation. 2005 Oct 18; 112(16):2477-86.
Score: 0.011
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Pergolide is an inhibitor of voltage-gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction. Circulation. 2005 Sep 06; 112(10):1494-9.
Score: 0.011
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Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest. 2005 Jun; 115(6):1479-91.
Score: 0.010
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Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. Circulation. 2004 Sep 14; 110(11):1372-9.
Score: 0.010
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Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation. 2004 Jun 22; 109(24):2947-52.
Score: 0.010
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In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation. 2003 Apr 22; 107(15):2037-44.
Score: 0.009
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Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2+, independent of membrane potential. Am J Physiol. 1999 09; 277(3):L662-6.
Score: 0.007
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Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats. Am J Physiol. 1999 08; 277(2):L423-9.
Score: 0.007
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Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology. Am J Physiol. 1999 02; 276(2):L213-9.
Score: 0.007
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The somatostatin analog angiopeptin does not reduce chronic hypoxic pulmonary hypertension in rats. Proc Soc Exp Biol Med. 1996 Oct; 213(1):43-9.
Score: 0.006
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Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells. J Appl Physiol (1985). 1994 Jun; 76(6):2611-5.
Score: 0.005
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Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure. J Appl Physiol (1985). 1993 Oct; 75(4):1748-57.
Score: 0.005
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Chronic hypoxic pulmonary hypertension. Is thrombin involved? Am Rev Respir Dis. 1993 Oct; 148(4 Pt 1):1043-8.
Score: 0.005
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Postischemic oxygen radical production varies with duration of ischemia. Am J Physiol. 1993 May; 264(5 Pt 2):H1478-84.
Score: 0.004
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H2O2 injury causes Ca(2+)-dependent and -independent hydrolysis of phosphatidylcholine in alveolar epithelial cells. Am J Physiol. 1992 Oct; 263(4 Pt 1):L430-8.
Score: 0.004
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Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol. 1992 Apr; 262(4 Pt 1):C882-90.
Score: 0.004
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Enhanced chemiluminescence as a measure of oxygen-derived free radical generation during ischemia and reperfusion. Circ Res. 1990 Dec; 67(6):1453-61.
Score: 0.004
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Hydroxylamine is a vasorelaxant and a possible intermediate in the oxidative conversion of L-arginine to nitric oxide. Biochem Biophys Res Commun. 1989 Aug 30; 163(1):527-33.
Score: 0.003