Christopher Rhodes to Animals
This is a "connection" page, showing publications Christopher Rhodes has written about Animals.
Connection Strength
2.019
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Are insect species imperilled? Critical factors and prevailing evidence for a potential global loss of the entomofauna: A current commentary. Sci Prog. 2019 06; 102(2):181-196.
Score: 0.044
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Plastic pollution and potential solutions. Sci Prog. 2018 Sep 01; 101(3):207-260.
Score: 0.042
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Pollinator decline - an ecological calamity in the making? Sci Prog. 2018 Jun 01; 101(2):121-160.
Score: 0.041
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ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats. Endocrinology. 2018 Feb 01; 159(2):895-906.
Score: 0.040
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The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions. Diabetes. 2016 09; 65(9):2711-23.
Score: 0.036
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Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function. Diabetes. 2016 Feb; 65(2):438-50.
Score: 0.034
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RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):356-66.
Score: 0.034
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Soil erosion, climate change and global food security: challenges and strategies. Sci Prog. 2014; 97(Pt 2):97-153.
Score: 0.031
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Direct autocrine action of insulin on ß-cells: does it make physiological sense? Diabetes. 2013 Jul; 62(7):2157-63.
Score: 0.029
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Pulmonary hypertension: biomarkers. Handb Exp Pharmacol. 2013; 218:77-103.
Score: 0.028
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Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Feb 01; 187(3):294-302.
Score: 0.028
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Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med. 2012 Aug 01; 2(8).
Score: 0.028
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Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets. Endocrinology. 2012 May; 153(5):2082-7.
Score: 0.027
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Modelling the influence of foot-and-mouth disease vaccine antigen stability and dose on the bovine immune response. PLoS One. 2012; 7(2):e30435.
Score: 0.027
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells. Diabetes. 2011 Nov; 60(11):2892-902.
Score: 0.026
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes. Diabetes. 2011 Nov; 60(11):2883-91.
Score: 0.026
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How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited. Diabetes. 2011 May; 60(5):1370-9.
Score: 0.025
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Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target. Eur Respir J. 2011 Dec; 38(6):1453-60.
Score: 0.025
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Electron spin resonance. Part one: a diagnostic method in the biomedical sciences. Sci Prog. 2011; 94(Pt 1):16-96.
Score: 0.025
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Variational data assimilation with epidemic models. J Theor Biol. 2009 Jun 21; 258(4):591-602.
Score: 0.022
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Contact rate calculation for a basic epidemic model. Math Biosci. 2008 Nov; 216(1):56-62.
Score: 0.021
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Therapeutic targets in pulmonary arterial hypertension. Pharmacol Ther. 2009 Jan; 121(1):69-88.
Score: 0.021
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation. Cell Metab. 2007 Mar; 5(3):221-7.
Score: 0.019
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Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing? Diabetes. 2007 Jan; 56(1):281-2.
Score: 0.019
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level. Diabetologia. 2006 Dec; 49(12):2920-9.
Score: 0.019
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10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it? Diabetologia. 2005 Nov; 48(11):R93-101.
Score: 0.017
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells. J Endocrinol. 2005 Apr; 185(1):57-67.
Score: 0.017
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Type 2 diabetes-a matter of beta-cell life and death? Science. 2005 Jan 21; 307(5708):380-4.
Score: 0.016
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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem. 2005 Jan 21; 280(3):2282-93.
Score: 0.016
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab. 2004 Aug; 287(2):E192-8.
Score: 0.016
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension. Sci Transl Med. 2024 01 10; 16(729):eadd2029.
Score: 0.015
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol. 2003 Nov 14; 209(1-2):17-31.
Score: 0.015
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem. 2003 Oct 24; 278(43):42080-90.
Score: 0.015
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells. Mol Cell Endocrinol. 2003 Jun 30; 204(1-2):85-99.
Score: 0.015
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SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension. Circulation. 2023 05 23; 147(21):1606-1621.
Score: 0.015
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Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH. Biochim Biophys Acta Mol Basis Dis. 2023 08; 1869(6):166697.
Score: 0.015
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells. Diabetes. 2003 Apr; 52(4):974-83.
Score: 0.014
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PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension. Cells. 2023 01 14; 12(2).
Score: 0.014
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Insulin secretory deficiency and glucose intolerance in Rab3A null mice. J Biol Chem. 2003 Mar 14; 278(11):9715-21.
Score: 0.014
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem. 2002 Dec 20; 277(51):49676-84.
Score: 0.014
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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes? Trends Mol Med. 2002 Aug; 8(8):375-84.
Score: 0.014
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Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes. 2002 Aug; 51(8):2496-504.
Score: 0.014
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Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life. Nat Commun. 2022 07 27; 13(1):4352.
Score: 0.014
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Molecular insights into insulin action and secretion. Eur J Clin Invest. 2002 Jun; 32 Suppl 3:3-13.
Score: 0.014
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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. J Biol Chem. 2002 Jul 05; 277(27):24232-42.
Score: 0.014
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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes. 2002 Apr; 51(4):966-76.
Score: 0.014
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Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain. Elife. 2022 02 17; 11.
Score: 0.013
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Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries. Mol Metab. 2022 01; 55:101392.
Score: 0.013
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BAd-CRISPR: Inducible gene knockout in interscapular brown adipose tissue of adult mice. J Biol Chem. 2021 12; 297(6):101402.
Score: 0.013
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Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set? Diabetes. 2001 Oct; 50(10):2181-91.
Score: 0.013
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A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis. Diabetes. 2001 Sep; 50(9):2029-39.
Score: 0.013
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NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity. Nat Commun. 2021 08 30; 12(1):5175.
Score: 0.013
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism. Diabetes. 2001 Aug; 50(8):1791-8.
Score: 0.013
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Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial. Sci Transl Med. 2021 04 21; 13(590).
Score: 0.013
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Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation. J Biol Chem. 2001 Jun 22; 276(25):22553-8.
Score: 0.013
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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem. 2001 Jun 15; 276(24):21110-20.
Score: 0.013
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A genetic map of the mouse dorsal vagal complex and its role in obesity. Nat Metab. 2021 04; 3(4):530-545.
Score: 0.013
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Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis. Nat Metab. 2020 05; 2(5):413-431.
Score: 0.012
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A fluorescent timer reporter enables sorting of insulin secretory granules by age. J Biol Chem. 2020 07 03; 295(27):8901-8911.
Score: 0.012
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Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice. JCI Insight. 2020 04 09; 5(7).
Score: 0.012
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice. Mol Cell Proteomics. 2020 06; 19(6):971-993.
Score: 0.012
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Nat Commun. 2020 03 04; 11(1):1185.
Score: 0.012
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Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding. Cell Metab. 2020 02 04; 31(2):301-312.e5.
Score: 0.012
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
Score: 0.012
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Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia. J Proteome Res. 2019 09 06; 18(9):3245-3258.
Score: 0.011
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Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice. Mol Metab. 2019 07; 25:64-72.
Score: 0.011
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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production. Nat Commun. 2019 02 12; 10(1):714.
Score: 0.011
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Identification of the Novel Tooth-Specific Transcription Factor AmeloD. J Dent Res. 2019 02; 98(2):234-241.
Score: 0.011
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Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes. Diabetes. 2019 01; 68(1):131-140.
Score: 0.011
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How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats. Diabetologia. 1998 Jul; 41(7):855-9.
Score: 0.010
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Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction. World J Gastroenterol. 2018 Apr 28; 24(16):1748-1765.
Score: 0.010
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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J. 1998 Apr 15; 331 ( Pt 2):553-61.
Score: 0.010
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Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology. 2018 04 01; 159(4):1860-1872.
Score: 0.010
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest. 1998 Mar 01; 101(5):1094-101.
Score: 0.010
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Epidemic thresholds and vaccination in a lattice model of disease spread. Theor Popul Biol. 1997 Oct; 52(2):101-18.
Score: 0.010
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Muon spectroscopy applied to biological systems: a study of thiyl radicals, RS. Free Radic Res. 1997 Oct; 27(4):347-52.
Score: 0.010
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Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity. Cell Rep. 2017 Sep 26; 20(13):3149-3161.
Score: 0.010
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Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1559-1569.
Score: 0.010
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The dynamic plasticity of insulin production in ß-cells. Mol Metab. 2017 09; 6(9):958-973.
Score: 0.010
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats. Diabetes. 2017 07; 66(7):2007-2018.
Score: 0.010
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Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis. Rheumatology (Oxford). 2017 04 01; 56(4):644-653.
Score: 0.010
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Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 01; 54(1):167-172.
Score: 0.009
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Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future. Pharmacol Ther. 2016 08; 164:195-203.
Score: 0.009
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In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug. Circulation. 2016 May 03; 133(18):1783-94.
Score: 0.009
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Expansion of the Knockdown Resistance Frequency Map for Human Head Lice (Phthiraptera: Pediculidae) in the United States Using Quantitative Sequencing. J Med Entomol. 2016 05; 53(3):653-659.
Score: 0.009
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Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line. Diabetes. 1996 Jan; 45(1):37-43.
Score: 0.009
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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells. Biochem J. 1996 Jan 01; 313 ( Pt 1):259-68.
Score: 0.009
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Local Joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis. Arthritis Rheumatol. 2015 Nov; 67(11):2877-87.
Score: 0.009
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Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets. Islets. 2015; 7(2):e1073435.
Score: 0.009
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Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 2016 Jan; 90(1):1-37.
Score: 0.009
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Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene. Nucleic Acids Res. 1995 Jun 25; 23(12):2305-13.
Score: 0.008
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Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus. J Neurosci. 2014 Nov 12; 34(46):15306-18.
Score: 0.008
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Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet. J Biol Chem. 1994 Nov 11; 269(45):27987-91.
Score: 0.008
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Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance. Nat Neurosci. 2014 Dec; 17(12):1744-1750.
Score: 0.008
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a1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders. Circ Cardiovasc Genet. 2014 Dec; 7(6):920-9.
Score: 0.008
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SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells. J Clin Invest. 2014 Oct; 124(10):4240-56.
Score: 0.008
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miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. Biochem J. 2014 Aug 15; 462(1):103-12.
Score: 0.008
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Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1. Biophys J. 2014 May 20; 106(10):2196-205.
Score: 0.008
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation. 2014 Apr 29; 129(17):1770-80.
Score: 0.008
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ß1 integrin is a crucial regulator of pancreatic ß-cell expansion. Development. 2013 Aug; 140(16):3360-72.
Score: 0.007
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Rabies and canine distemper virus epidemics in the red fox population of northern Italy (2006-2010). PLoS One. 2013; 8(4):e61588.
Score: 0.007
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Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. J Biol Chem. 1993 Feb 25; 268(6):4267-75.
Score: 0.007
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Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. J Biol Chem. 1992 Nov 15; 267(32):22719-27.
Score: 0.007
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Degradation of islet amyloid polypeptide by neprilysin. Diabetologia. 2012 Nov; 55(11):2989-98.
Score: 0.007
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Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells. Curr Mol Med. 2012 May; 12(4):467-75.
Score: 0.007
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Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
Score: 0.007
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BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH. Hum Mol Genet. 2012 Jun 01; 21(11):2548-58.
Score: 0.007
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Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):1-7.
Score: 0.007
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The enzymology of proinsulin conversion. Cell Biophys. 1991 Oct-Dec; 19(1-3):57-62.
Score: 0.007
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Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes. 2011 Nov; 60(11):2843-52.
Score: 0.007
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Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab. 2011 Sep 07; 14(3):313-23.
Score: 0.006
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation. PLoS One. 2011 Apr 26; 6(4):e18146.
Score: 0.006
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Characterization of the promoter for the rat and human link protein gene. Nucleic Acids Res. 1991 Apr 25; 19(8):1933-9.
Score: 0.006
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Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol. 2011 Mar; 31(2):95-107.
Score: 0.006
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Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci. 2011 Feb 02; 31(5):1873-84.
Score: 0.006
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets. Biochem Pharmacol. 2011 Apr 15; 81(8):1016-27.
Score: 0.006
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Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts. Endocrinology. 2011 Feb; 152(2):436-46.
Score: 0.006
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Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci. 2010 Aug 25; 30(34):11278-87.
Score: 0.006
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass. Diabetologia. 2010 Nov; 53(11):2369-79.
Score: 0.006
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Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1. J Endocrinol. 2010 Aug; 206(2):171-81.
Score: 0.006
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Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci. 2010 Apr 21; 30(16):5713-23.
Score: 0.006
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2010 Apr; 59(4):967-77.
Score: 0.006
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol. 2010 Mar; 298(3):R720-8.
Score: 0.006
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AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death. J Biol Chem. 2010 Jan 29; 285(5):3191-200.
Score: 0.006
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Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules. J Biol Chem. 1989 Aug 25; 264(24):14240-5.
Score: 0.006
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Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab. 2009 Aug; 10(2):89-98.
Score: 0.006
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells. Mol Cell Endocrinol. 2009 Nov 13; 311(1-2):32-8.
Score: 0.006
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Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology. 2009 Oct; 150(10):4502-11.
Score: 0.006
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes. 2009 Sep; 58(9):2048-58.
Score: 0.006
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Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci. 2009 Mar 11; 29(10):3138-47.
Score: 0.005
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The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides. Biochem J. 1989 Feb 15; 258(1):305-8.
Score: 0.005
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Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Endocrinology. 2009 Feb; 150(2):580-91.
Score: 0.005
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Alternative splicing generates two different mRNA species for rat link protein. J Biol Chem. 1988 May 05; 263(13):6063-7.
Score: 0.005
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The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide. Biochem J. 1988 Apr 01; 251(1):23-30.
Score: 0.005
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Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump. J Biol Chem. 1987 Aug 05; 262(22):10712-7.
Score: 0.005
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Complex interactions with females and rival males limit the evolution of sperm offence and defence. Proc Biol Sci. 2007 Jul 22; 274(1619):1779-88.
Score: 0.005
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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway. J Cell Biol. 1987 Jul; 105(1):145-53.
Score: 0.005
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Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. Mol Endocrinol. 2007 Sep; 21(9):2255-69.
Score: 0.005
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Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets. FEBS Lett. 1987 May 04; 215(1):179-82.
Score: 0.005
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The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. J Biol Chem. 2006 Nov 24; 281(47):35624-32.
Score: 0.005
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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes. 2006 Aug; 55(8):2192-201.
Score: 0.005
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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem. 2006 Aug 25; 281(34):24293-303.
Score: 0.005
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Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol. 2006 Apr; 26(7):2675-87.
Score: 0.004
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem. 2006 Jun 09; 281(23):15884-92.
Score: 0.004
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Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006 Mar 10; 160(1):1-40.
Score: 0.004
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Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab. 2006 Jan; 3(1):67-73.
Score: 0.004
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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2005 Dec; 2(6):411-20.
Score: 0.004
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Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells. Diabetes. 2005 Nov; 54(11):3073-81.
Score: 0.004
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Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci. 2005 Oct 15; 118(Pt 20):4797-812.
Score: 0.004
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Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68.
Score: 0.004
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Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia. 2005 Jul; 48(7):1339-49.
Score: 0.004
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Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans. Biochem J. 1985 May 15; 228(1):87-94.
Score: 0.004
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Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest. 2005 Mar; 115(3):703-10.
Score: 0.004
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Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport. J Biol Chem. 2005 Apr 15; 280(15):14536-44.
Score: 0.004
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2-5A-dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2-5A core) in mouse pancreatic islets. FEBS Lett. 1985 Jan 21; 180(1):69-73.
Score: 0.004
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The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem. 2005 Feb 11; 280(6):4617-26.
Score: 0.004
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Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. 2004 Nov; 266(1-2):37-56.
Score: 0.004
-
Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis. Biophys J. 2004 Dec; 87(6):L03-5.
Score: 0.004
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Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element. BMC Mol Biol. 2004 Sep 06; 5:15.
Score: 0.004
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Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population. Biochem J. 2004 Jun 15; 380(Pt 3):897-905.
Score: 0.004
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Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9266-71.
Score: 0.004
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A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes. 2004 Apr; 53(4):1007-19.
Score: 0.004
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Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia. 2004 Mar; 47(3):478-487.
Score: 0.004
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Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide. Diabetes. 2004 Jan; 53(1):141-8.
Score: 0.004
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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem. 2003 Aug 08; 278(32):30015-21.
Score: 0.004
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Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology. 2003 May; 144(5):2016-24.
Score: 0.004
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells. Mol Endocrinol. 2003 May; 17(5):945-58.
Score: 0.004
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Absolute quantification of myocardial blood flow with H(2)(15)O and 3-dimensional PET: an experimental validation. J Nucl Med. 2002 Aug; 43(8):1031-40.
Score: 0.003
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Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature. 2001 Oct 25; 413(6858):794-5.
Score: 0.003
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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation. Diabetes. 2001 Oct; 50(10):2237-43.
Score: 0.003
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The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti. Hum Mol Genet. 2001 Mar 01; 10(5):507-12.
Score: 0.003
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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1. Endocrinology. 2001 Jan; 142(1):229-40.
Score: 0.003
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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes. 2000 Jul; 49(7):1239-48.
Score: 0.003
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Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells). J Biol Chem. 2000 Mar 31; 275(13):9363-8.
Score: 0.003
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Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. Am J Physiol Endocrinol Metab. 2000 Mar; 278(3):E563-9.
Score: 0.003
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Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. Diabetes. 2000 Mar; 49(3):383-91.
Score: 0.003
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Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
Score: 0.003
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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14911-8.
Score: 0.003
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochem J. 1999 Dec 15; 344 Pt 3:649-58.
Score: 0.003
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Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
Score: 0.003
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Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells. FEBS Lett. 1998 Dec 11; 441(1):97-102.
Score: 0.003
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J. 1998 Sep 01; 17(17):5048-58.
Score: 0.003
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 1998 Jul; 47(7):1074-85.
Score: 0.003
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Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins. Proc Natl Acad Sci U S A. 1996 Dec 24; 93(26):15169-73.
Score: 0.002
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Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8595-600.
Score: 0.002
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The c-propeptide of type II procollagen binds to the enhancer region of the type II procollagen gene and regulates its transcription. Ann N Y Acad Sci. 1996 Jun 08; 785:307-8.
Score: 0.002
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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells. Science. 1996 Feb 09; 271(5250):813-5.
Score: 0.002
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A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells. Biochem J. 1996 Jan 01; 313 ( Pt 1):97-107.
Score: 0.002
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J Clin Invest. 1995 Mar; 95(3):1032-9.
Score: 0.002
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A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor. Biochem J. 1994 Jul 01; 301 ( Pt 1):257-65.
Score: 0.002
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Score: 0.002
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The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem. 1993 Feb 25; 268(6):4276-80.
Score: 0.002
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Ca(2+)-regulated serine protease associated with the nuclear scaffold. Cell Growth Differ. 1992 Nov; 3(11):827-38.
Score: 0.002
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The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs. Mol Cell Endocrinol. 1992 Aug; 86(3):177-86.
Score: 0.002
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Score: 0.002
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Score: 0.001
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Score: 0.001
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Score: 0.001
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Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin. J Biol Chem. 1989 Nov 05; 264(31):18335-9.
Score: 0.001
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Score: 0.001
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Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. Biochem J. 1989 Jan 15; 257(2):431-7.
Score: 0.001
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[Biogenesis of the insulin secretion granule]. Journ Annu Diabetol Hotel Dieu. 1989; 13-28.
Score: 0.001
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Score: 0.001
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Score: 0.001
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Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus. Diabetologia. 1984 May; 26(5):370-4.
Score: 0.001