Christopher Rhodes to Male
This is a "connection" page, showing publications Christopher Rhodes has written about Male.
Connection Strength
0.963
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GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic ß-cell function in obese male mice. Nat Commun. 2025 May 21; 16(1):4714.
Score: 0.046
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Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension. Circulation. 2024 Oct 15; 150(16):1268-1287.
Score: 0.043
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Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome. Am J Respir Crit Care Med. 2020 08 15; 202(4):586-594.
Score: 0.033
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Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med. 2019 03; 7(3):227-238.
Score: 0.029
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ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats. Endocrinology. 2018 Feb 01; 159(2):895-906.
Score: 0.028
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Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study. Lancet Respir Med. 2017 09; 5(9):717-726.
Score: 0.026
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Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension. Circulation. 2017 01 31; 135(5):460-475.
Score: 0.025
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The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions. Diabetes. 2016 09; 65(9):2711-23.
Score: 0.024
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RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):356-66.
Score: 0.023
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Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Feb 01; 187(3):294-302.
Score: 0.019
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Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets. Endocrinology. 2012 May; 153(5):2082-7.
Score: 0.018
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells. Diabetes. 2011 Nov; 60(11):2892-902.
Score: 0.018
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Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights. J Am Coll Cardiol. 2011 Jul 12; 58(3):300-9.
Score: 0.018
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Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension. Heart. 2011 Jul; 97(13):1054-60.
Score: 0.017
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Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target. Eur Respir J. 2011 Dec; 38(6):1453-60.
Score: 0.017
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Electron spin resonance. Part one: a diagnostic method in the biomedical sciences. Sci Prog. 2011; 94(Pt 1):16-96.
Score: 0.017
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation. Cell Metab. 2007 Mar; 5(3):221-7.
Score: 0.013
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level. Diabetologia. 2006 Dec; 49(12):2920-9.
Score: 0.013
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Clustering Patients with Pulmonary Hypertension Using the Plasma Proteome. Am J Respir Crit Care Med. 2025 Aug; 211(8):1492-1503.
Score: 0.012
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Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension. Circ Genom Precis Med. 2025 Jun; 18(3):e004862.
Score: 0.011
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Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP. Mol Metab. 2025 Feb; 92:102093.
Score: 0.011
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Sex-Specific Genetic Determinants of Right Ventricular Structure and Function. Am J Respir Crit Care Med. 2025 Jan; 211(1):113-123.
Score: 0.011
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Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss. Mol Metab. 2025 May; 95:102074.
Score: 0.011
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Ferroptosis-Mediated Inflammation Promotes Pulmonary Hypertension. Circ Res. 2024 Nov 08; 135(11):1067-1083.
Score: 0.011
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Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism. Am J Respir Crit Care Med. 2024 06 15; 209(12):1477-1485.
Score: 0.011
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol. 2003 Nov 14; 209(1-2):17-31.
Score: 0.010
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem. 2003 Oct 24; 278(43):42080-90.
Score: 0.010
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells. Mol Cell Endocrinol. 2003 Jun 30; 204(1-2):85-99.
Score: 0.010
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Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity. Diabetes Care. 2023 05 01; 46(5):985-992.
Score: 0.010
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Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH. Biochim Biophys Acta Mol Basis Dis. 2023 08; 1869(6):166697.
Score: 0.010
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells. Diabetes. 2003 Apr; 52(4):974-83.
Score: 0.010
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Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes. 2002 Aug; 51(8):2496-504.
Score: 0.009
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Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension. Eur Respir J. 2022 03; 59(3).
Score: 0.009
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Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries. Mol Metab. 2022 01; 55:101392.
Score: 0.009
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NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity. Nat Commun. 2021 08 30; 12(1):5175.
Score: 0.009
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism. Diabetes. 2001 Aug; 50(8):1791-8.
Score: 0.009
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Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency. Chest. 2021 10; 160(4):1442-1458.
Score: 0.009
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A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach. EBioMedicine. 2021 Jul; 69:103444.
Score: 0.009
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A genetic map of the mouse dorsal vagal complex and its role in obesity. Nat Metab. 2021 04; 3(4):530-545.
Score: 0.009
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Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension. Genes (Basel). 2020 10 22; 11(11).
Score: 0.008
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Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis. Nat Metab. 2020 05; 2(5):413-431.
Score: 0.008
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A fluorescent timer reporter enables sorting of insulin secretory granules by age. J Biol Chem. 2020 07 03; 295(27):8901-8911.
Score: 0.008
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Nat Commun. 2020 03 04; 11(1):1185.
Score: 0.008
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Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2020 03 01; 201(5):575-585.
Score: 0.008
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Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding. Cell Metab. 2020 02 04; 31(2):301-312.e5.
Score: 0.008
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Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis. Biochem Biophys Res Commun. 2020 02 12; 522(3):731-735.
Score: 0.008
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Metabolic pathways associated with right ventricular adaptation to pulmonary hypertension: 3D analysis of cardiac magnetic resonance imaging. Eur Heart J Cardiovasc Imaging. 2019 Jun 01; 20(6):668-676.
Score: 0.008
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Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis. Eur Respir J. 2019 05; 53(5).
Score: 0.008
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Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice. Mol Metab. 2019 07; 25:64-72.
Score: 0.008
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The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension. Eur Respir J. 2019 03; 53(3).
Score: 0.007
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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production. Nat Commun. 2019 02 12; 10(1):714.
Score: 0.007
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Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension. Thorax. 2019 04; 74(4):380-389.
Score: 0.007
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Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction. World J Gastroenterol. 2018 Apr 28; 24(16):1748-1765.
Score: 0.007
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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J. 1998 Apr 15; 331 ( Pt 2):553-61.
Score: 0.007
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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension. Nat Commun. 2018 04 12; 9(1):1416.
Score: 0.007
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest. 1998 Mar 01; 101(5):1094-101.
Score: 0.007
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Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata. Cell Metab. 2017 Sep 05; 26(3):568-575.e3.
Score: 0.007
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats. Diabetes. 2017 07; 66(7):2007-2018.
Score: 0.007
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Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis. Rheumatology (Oxford). 2017 04 01; 56(4):644-653.
Score: 0.007
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Machine Learning of Three-dimensional Right Ventricular Motion Enables Outcome Prediction in Pulmonary Hypertension: A Cardiac MR Imaging Study. Radiology. 2017 05; 283(2):381-390.
Score: 0.006
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In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug. Circulation. 2016 May 03; 133(18):1783-94.
Score: 0.006
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The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression. Arthritis Res Ther. 2016 Mar 11; 18:61.
Score: 0.006
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Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology. J Shoulder Elbow Surg. 2016 Jun; 25(6):989-97.
Score: 0.006
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Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets. Islets. 2015; 7(2):e1073435.
Score: 0.006
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Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus. J Neurosci. 2014 Nov 12; 34(46):15306-18.
Score: 0.006
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Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance. Nat Neurosci. 2014 12; 17(12):1744-1750.
Score: 0.006
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a1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders. Circ Cardiovasc Genet. 2014 Dec; 7(6):920-9.
Score: 0.006
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miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. Biochem J. 2014 Aug 15; 462(1):103-12.
Score: 0.005
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation. 2014 Apr 29; 129(17):1770-80.
Score: 0.005
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Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells. Curr Mol Med. 2012 May; 12(4):467-75.
Score: 0.005
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An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. J Cereb Blood Flow Metab. 2012 Jan; 32(1):1-5.
Score: 0.004
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Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes. 2011 Nov; 60(11):2843-52.
Score: 0.004
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Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab. 2011 Sep 07; 14(3):313-23.
Score: 0.004
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation. PLoS One. 2011 Apr 26; 6(4):e18146.
Score: 0.004
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets. Biochem Pharmacol. 2011 Apr 15; 81(8):1016-27.
Score: 0.004
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Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts. Endocrinology. 2011 Feb; 152(2):436-46.
Score: 0.004
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Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci. 2010 Aug 25; 30(34):11278-87.
Score: 0.004
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass. Diabetologia. 2010 Nov; 53(11):2369-79.
Score: 0.004
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Simvastatin as a treatment for pulmonary hypertension trial. Am J Respir Crit Care Med. 2010 May 15; 181(10):1106-13.
Score: 0.004
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2010 Apr; 59(4):967-77.
Score: 0.004
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol. 2010 Mar; 298(3):R720-8.
Score: 0.004
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AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death. J Biol Chem. 2010 Jan 29; 285(5):3191-200.
Score: 0.004
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Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology. 2009 Oct; 150(10):4502-11.
Score: 0.004
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Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci. 2009 Mar 11; 29(10):3138-47.
Score: 0.004
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Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Endocrinology. 2009 Feb; 150(2):580-91.
Score: 0.004
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The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide. Biochem J. 1988 Apr 01; 251(1):23-30.
Score: 0.003
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Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump. J Biol Chem. 1987 Aug 05; 262(22):10712-7.
Score: 0.003
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Complex interactions with females and rival males limit the evolution of sperm offence and defence. Proc Biol Sci. 2007 Jul 22; 274(1619):1779-88.
Score: 0.003
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Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets. FEBS Lett. 1987 May 04; 215(1):179-82.
Score: 0.003
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Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab. 2006 Jan; 3(1):67-73.
Score: 0.003
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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2005 Dec; 2(6):411-20.
Score: 0.003
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Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia. 2005 Jul; 48(7):1339-49.
Score: 0.003
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Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans. Biochem J. 1985 May 15; 228(1):87-94.
Score: 0.003
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Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function. Clin Sci (Lond). 1985 May; 68(5):567-72.
Score: 0.003
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Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest. 2005 Mar; 115(3):703-10.
Score: 0.003
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2-5A-dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2-5A core) in mouse pancreatic islets. FEBS Lett. 1985 Jan 21; 180(1):69-73.
Score: 0.003
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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem. 2003 Aug 08; 278(32):30015-21.
Score: 0.002
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Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. Am J Physiol Endocrinol Metab. 2000 Mar; 278(3):E563-9.
Score: 0.002
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Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. Diabetes. 2000 Mar; 49(3):383-91.
Score: 0.002
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Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
Score: 0.002
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J. 1998 Sep 01; 17(17):5048-58.
Score: 0.002
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Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (ClO2.). Free Radic Res. 1997 Mar; 26(3):209-34.
Score: 0.002
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J Clin Invest. 1995 Mar; 95(3):1032-9.
Score: 0.001
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The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem. 1993 Feb 25; 268(6):4276-80.
Score: 0.001
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Exclusion of human proteoglycan link protein (CRTL1) and type II collagen (COL2A1) genes in pseudoachondroplasia. Am J Med Genet. 1992 Nov 01; 44(4):420-4.
Score: 0.001
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Ca(2+)-regulated serine protease associated with the nuclear scaffold. Cell Growth Differ. 1992 Nov; 3(11):827-38.
Score: 0.001
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Unsuitability of indoxyl acetate as a substrate for the assay of testicular hyaluronidase. Biochem J. 1971 May; 122(4):575-82.
Score: 0.001
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Hydrolysis of indoxyl acetate by bovine testicular hyaluronidase preparations. Biochem J. 1970 Jun; 118(2):18P-19P.
Score: 0.001
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Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus. Diabetologia. 1984 May; 26(5):370-4.
Score: 0.001