Christopher Rhodes to Rats
This is a "connection" page, showing publications Christopher Rhodes has written about Rats.
Connection Strength
1.860
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ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats. Endocrinology. 2018 Feb 01; 159(2):895-906.
Score: 0.100
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Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Feb 01; 187(3):294-302.
Score: 0.070
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Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets. Endocrinology. 2012 May; 153(5):2082-7.
Score: 0.066
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells. Diabetes. 2011 Nov; 60(11):2892-902.
Score: 0.064
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes. Diabetes. 2011 Nov; 60(11):2883-91.
Score: 0.064
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How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited. Diabetes. 2011 May; 60(5):1370-9.
Score: 0.063
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Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target. Eur Respir J. 2011 Dec; 38(6):1453-60.
Score: 0.062
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation. Cell Metab. 2007 Mar; 5(3):221-7.
Score: 0.047
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level. Diabetologia. 2006 Dec; 49(12):2920-9.
Score: 0.046
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells. J Endocrinol. 2005 Apr; 185(1):57-67.
Score: 0.041
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab. 2004 Aug; 287(2):E192-8.
Score: 0.039
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension. Sci Transl Med. 2024 01 10; 16(729):eadd2029.
Score: 0.038
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol. 2003 Nov 14; 209(1-2):17-31.
Score: 0.037
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem. 2003 Oct 24; 278(43):42080-90.
Score: 0.037
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells. Mol Cell Endocrinol. 2003 Jun 30; 204(1-2):85-99.
Score: 0.036
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells. Diabetes. 2003 Apr; 52(4):974-83.
Score: 0.036
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem. 2002 Dec 20; 277(51):49676-84.
Score: 0.035
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Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes. 2002 Aug; 51(8):2496-504.
Score: 0.034
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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. J Biol Chem. 2002 Jul 05; 277(27):24232-42.
Score: 0.034
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A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis. Diabetes. 2001 Sep; 50(9):2029-39.
Score: 0.032
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism. Diabetes. 2001 Aug; 50(8):1791-8.
Score: 0.032
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Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation. J Biol Chem. 2001 Jun 22; 276(25):22553-8.
Score: 0.031
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
Score: 0.029
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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production. Nat Commun. 2019 02 12; 10(1):714.
Score: 0.027
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How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats. Diabetologia. 1998 Jul; 41(7):855-9.
Score: 0.026
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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J. 1998 Apr 15; 331 ( Pt 2):553-61.
Score: 0.025
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest. 1998 Mar 01; 101(5):1094-101.
Score: 0.025
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats. Diabetes. 2017 07; 66(7):2007-2018.
Score: 0.024
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Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets. Islets. 2015; 7(2):e1073435.
Score: 0.021
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Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene. Nucleic Acids Res. 1995 Jun 25; 23(12):2305-13.
Score: 0.021
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation. 2014 Apr 29; 129(17):1770-80.
Score: 0.019
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Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. J Biol Chem. 1993 Feb 25; 268(6):4267-75.
Score: 0.018
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Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. J Biol Chem. 1992 Nov 15; 267(32):22719-27.
Score: 0.017
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Degradation of islet amyloid polypeptide by neprilysin. Diabetologia. 2012 Nov; 55(11):2989-98.
Score: 0.017
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Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells. Curr Mol Med. 2012 May; 12(4):467-75.
Score: 0.017
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BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH. Hum Mol Genet. 2012 Jun 01; 21(11):2548-58.
Score: 0.017
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Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):1-7.
Score: 0.017
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Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes. 2011 Nov; 60(11):2843-52.
Score: 0.016
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Characterization of the promoter for the rat and human link protein gene. Nucleic Acids Res. 1991 Apr 25; 19(8):1933-9.
Score: 0.016
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Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci. 2011 Feb 02; 31(5):1873-84.
Score: 0.015
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets. Biochem Pharmacol. 2011 Apr 15; 81(8):1016-27.
Score: 0.015
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass. Diabetologia. 2010 Nov; 53(11):2369-79.
Score: 0.015
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2010 Apr; 59(4):967-77.
Score: 0.014
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol. 2010 Mar; 298(3):R720-8.
Score: 0.014
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AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death. J Biol Chem. 2010 Jan 29; 285(5):3191-200.
Score: 0.014
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Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules. J Biol Chem. 1989 Aug 25; 264(24):14240-5.
Score: 0.014
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells. Mol Cell Endocrinol. 2009 Nov 13; 311(1-2):32-8.
Score: 0.014
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Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology. 2009 Oct; 150(10):4502-11.
Score: 0.014
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes. 2009 Sep; 58(9):2048-58.
Score: 0.014
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The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides. Biochem J. 1989 Feb 15; 258(1):305-8.
Score: 0.013
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Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell. Endocrinology. 2009 Feb; 150(2):580-91.
Score: 0.013
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Alternative splicing generates two different mRNA species for rat link protein. J Biol Chem. 1988 May 05; 263(13):6063-7.
Score: 0.013
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The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide. Biochem J. 1988 Apr 01; 251(1):23-30.
Score: 0.013
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Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump. J Biol Chem. 1987 Aug 05; 262(22):10712-7.
Score: 0.012
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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway. J Cell Biol. 1987 Jul; 105(1):145-53.
Score: 0.012
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Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets. FEBS Lett. 1987 May 04; 215(1):179-82.
Score: 0.012
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The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. J Biol Chem. 2006 Nov 24; 281(47):35624-32.
Score: 0.011
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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes. 2006 Aug; 55(8):2192-201.
Score: 0.011
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells. J Biol Chem. 2006 Jun 09; 281(23):15884-92.
Score: 0.011
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Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab. 2006 Jan; 3(1):67-73.
Score: 0.011
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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2005 Dec; 2(6):411-20.
Score: 0.011
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Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia. 2005 Jul; 48(7):1339-49.
Score: 0.010
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Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest. 2005 Mar; 115(3):703-10.
Score: 0.010
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Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis. Biophys J. 2004 Dec; 87(6):L03-5.
Score: 0.010
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Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element. BMC Mol Biol. 2004 Sep 06; 5:15.
Score: 0.010
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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem. 2003 Aug 08; 278(32):30015-21.
Score: 0.009
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Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology. 2003 May; 144(5):2016-24.
Score: 0.009
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells. Mol Endocrinol. 2003 May; 17(5):945-58.
Score: 0.009
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Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature. 2001 Oct 25; 413(6858):794-5.
Score: 0.008
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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation. Diabetes. 2001 Oct; 50(10):2237-43.
Score: 0.008
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Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. Am J Physiol Endocrinol Metab. 2000 Mar; 278(3):E563-9.
Score: 0.007
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Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. Diabetes. 2000 Mar; 49(3):383-91.
Score: 0.007
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Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81.
Score: 0.007
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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14911-8.
Score: 0.007
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochem J. 1999 Dec 15; 344 Pt 3:649-58.
Score: 0.007
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Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95.
Score: 0.007
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J. 1998 Sep 01; 17(17):5048-58.
Score: 0.007
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes. 1998 Jul; 47(7):1074-85.
Score: 0.006
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A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells. Biochem J. 1996 Jan 01; 313 ( Pt 1):97-107.
Score: 0.005
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J Clin Invest. 1995 Mar; 95(3):1032-9.
Score: 0.005
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A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor. Biochem J. 1994 Jul 01; 301 ( Pt 1):257-65.
Score: 0.005
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The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets. J Biol Chem. 1993 Feb 25; 268(6):4276-80.
Score: 0.004
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Ca(2+)-regulated serine protease associated with the nuclear scaffold. Cell Growth Differ. 1992 Nov; 3(11):827-38.
Score: 0.004
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Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans. Biochem J. 1989 Dec 01; 264(2):503-8.
Score: 0.004
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Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. Biochem J. 1989 Jan 15; 257(2):431-7.
Score: 0.003
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[Biogenesis of the insulin secretion granule]. Journ Annu Diabetol Hotel Dieu. 1989; 13-28.
Score: 0.003
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Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Nature. 1988 May 05; 333(6168):93-6.
Score: 0.003
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High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin. Diabetologia. 1986 Dec; 29(12):893-6.
Score: 0.003