Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel.

Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel. J Pharmacol Toxicol Methods. 2024 Nov-Dec; 130:107566.

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subject areas

Animals
Arrhythmias, Cardiac
Cell Culture Techniques
Cell Proliferation
CHO Cells
Cricetulus
Culture Media, Serum-Free
KCNQ1 Potassium Channel
Potassium Channels, Voltage-Gated
Probucol
Time Factors

authors with profiles

Alain J. Labro