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Godley, Lucy
One or more keywords matched the following items that are connected to Godley, Lucy
Item TypeName
Concept Breast Neoplasms
Concept Colonic Neoplasms
Concept Uterine Cervical Neoplasms
Concept Genetic Vectors
Concept Mammary Neoplasms, Experimental
Concept Genetics, Medical
Concept Pancreatic Neoplasms
Concept Ovarian Neoplasms
Concept Mediastinal Neoplasms
Concept Polymorphism, Genetic
Concept Risk Factors
Concept Risk
Concept Transcription, Genetic
Concept Genetic Variation
Concept Risk Assessment
Concept Central Nervous System Neoplasms
Concept Neoplasms, Second Primary
Concept Neoplasms, Experimental
Concept Genetic Association Studies
Concept Genetic Diseases, Inborn
Concept Databases, Genetic
Concept Promoter Regions, Genetic
Concept Hematologic Neoplasms
Concept Crosses, Genetic
Concept Enhancer Elements, Genetic
Concept Epistasis, Genetic
Concept Genetic Counseling
Concept Genetic Testing
Concept Neoplasms
Concept Translocation, Genetic
Concept Genetic Predisposition to Disease
Concept Epigenesis, Genetic
Academic Article The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model.
Academic Article Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.
Academic Article Pre-transplant ganciclovir and post transplant high-dose valacyclovir reduce CMV infections after alemtuzumab-based conditioning.
Academic Article Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins.
Academic Article A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia.
Academic Article Therapy-related myeloid leukemia.
Academic Article Deletion of the der(9q) in chronic myeloid leukemia: the controversy continues.
Academic Article Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation.
Academic Article The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma.
Academic Article Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines.
Academic Article Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease.
Academic Article Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant.
Academic Article Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage.
Academic Article Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Academic Article Aberrant RNA splicing and its functional consequences in cancer cells.
Academic Article The use of hypomethylating agents in the treatment of hematologic malignancies.
Academic Article Successful allogeneic transplantation of patients with suspected prior invasive mold infection.
Academic Article DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.
Academic Article High dose cytarabine and mitoxantrone: an effective induction regimen for high-risk acute myeloid leukemia (AML).
Academic Article Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
Academic Article TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.
Academic Article Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation.
Academic Article Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.
Academic Article The histone code and treatments for acute myeloid leukemia.
Academic Article Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma.
Academic Article Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation.
Academic Article Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Academic Article An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Academic Article Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.
Academic Article HMGA2 levels in CML: reflective of miRNA gene regulation in a hematopoietic tumor?
Academic Article Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.
Academic Article Profiles in leukemia.
Academic Article Fludarabine, melphalan, and alemtuzumab conditioning in adults with standard-risk advanced acute myeloid leukemia and myelodysplastic syndrome.
Academic Article The identification and characterisation of novel KIT transcripts in aggressive mast cell malignancies and normal CD34+ cells.
Academic Article DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
Academic Article Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.
Academic Article Defining the steps in a multistep mouse model for mammary carcinogenesis.
Academic Article Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis.
Academic Article Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia.
Academic Article High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis.
Academic Article Perspectives and future directions for epigenetics in hematology.
Academic Article Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits.
Academic Article Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
Academic Article Proposal for the clinical detection and management of patients and their family members with familial myelodysplastic syndrome/acute leukemia predisposition syndromes.
Academic Article Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells.
Academic Article Immune reconstitution after combined haploidentical and umbilical cord blood transplant.
Academic Article Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.
Academic Article Randomized open-label phase II study of decitabine in patients with low- or intermediate-risk myelodysplastic syndromes.
Academic Article TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
Academic Article Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.
Academic Article A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes.
Academic Article Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma.
Academic Article New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.
Academic Article Inherited predisposition to acute myeloid leukemia.
Academic Article DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
Academic Article Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Academic Article Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
Academic Article A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia.
Academic Article Alterations of 5-hydroxymethylcytosine in human cancers.
Academic Article Large conserved domains of low DNA methylation maintained by Dnmt3a.
Academic Article DNMT3B7 expression promotes tumor progression to a more aggressive phenotype in breast cancer cells.
Academic Article The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
Academic Article Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes.
Academic Article A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies.
Academic Article Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations.
Academic Article On the origin of leukemic species.
Academic Article Linking the genetic architecture of cytosine modifications with human complex traits.
Academic Article TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.
Academic Article 5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy.
Academic Article DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
Academic Article Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Academic Article TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer.
Academic Article Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.
Academic Article Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation.
Academic Article Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice.
Academic Article Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
Academic Article Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Academic Article Corrigendum: TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer.
Academic Article Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival.
Academic Article Frequency and Risk Factors Associated with Cord Graft Failure after Transplant with Single-Unit Umbilical Cord Cells Supplemented by Haploidentical Cells with Reduced-Intensity Conditioning.
Academic Article Rigosertib versus best supportive care for patients with high-risk myelodysplastic syndromes after failure of hypomethylating drugs (ONTIME): a randomised, controlled, phase 3 trial.
Academic Article Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC).
Academic Article Incidence and predictors of respiratory viral infections by multiplex PCR in allogeneic hematopoietic cell transplant recipients 50 years and older including geriatric assessment.
Academic Article Erratum to "5-hydroxymethylcytosine in cancer: Significance in diagnosis and therapy" [Cancer Genet 208 (2015):167-177].
Academic Article Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes.
Academic Article Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy.
Academic Article Genetic predisposition to leukemia and other hematologic malignancies.
Academic Article How I diagnose and manage individuals at risk for inherited myeloid malignancies.
Academic Article Germline ETV6 mutations and predisposition to hematological malignancies.
Academic Article Genetic predisposition to hematologic malignancies: management and surveillance.
Academic Article Recognition of familial myeloid neoplasia in adults.
Academic Article Therapy-related myeloid neoplasms: when genetics and environment collide.
Academic Article Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies.
Academic Article Clinical Assessment and Diagnosis of Germline Predisposition to Hematopoietic Malignancies: The University of Chicago Experience.
Academic Article Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.
Academic Article Hereditary Myelodysplastic Syndrome and Acute Myeloid Leukemia: Diagnosis, Questions, and Controversies.
Academic Article Treatment of Acute Promyelocytic Leukemia in Adults.
Academic Article MBD4: guardian of the epigenetic galaxy.
Academic Article Identifying patients with genetic predisposition to acute myeloid leukemia.
Academic Article Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.
Academic Article Characterization of cancer comorbidity prior to allogeneic hematopoietic cell transplantation.
Academic Article Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes.
Academic Article Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.
Academic Article Somatic mutation panels: Time to clear their names.
Academic Article FouNdER mutations confer risk for leukemias.
Academic Article Inherited predisposition to myeloid malignancies.
Academic Article ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.
Academic Article 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Academic Article A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia.
Academic Article How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies.
Academic Article RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.
Academic Article Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome.
Academic Article Inherited Thrombocytopenia Caused by Germline ANKRD26 Mutation Should Be Considered in Young Patients With Suspected Myelodysplastic Syndrome.
Academic Article Assessment of technical heterogeneity among diagnostic tests to detect germline risk variants for hematopoietic malignancies.
Academic Article Regulation of telomeric function by DNA methylation differs between humans and mice.
Academic Article Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies.
Academic Article Identifying potential germline variants from sequencing hematopoietic malignancies.
Academic Article Identifying potential germline variants from sequencing hematopoietic malignancies.
Academic Article Germline mutations in MDS/AML predisposition disorders.
Academic Article Germline variants drive myelodysplastic syndrome in young adults.
Academic Article Inherited predisposition to haematopoietic malignancies: overcoming barriers and exploring opportunities.
Academic Article Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer.
Academic Article RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function.
Academic Article Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model.
Academic Article Clinical features and survival outcomes in patients with chronic myelomonocytic leukemia arising in the context of germline predisposition syndromes.
Academic Article Germline predisposition to hematopoietic malignancies.
Academic Article The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy.
Academic Article Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites.
Academic Article Genetics of Myelodysplastic Syndromes.
Academic Article Anticipation in hematopoietic malignancies: biology, bias, or both?
Academic Article Therapy-related myeloid neoplasms in 109 patients after radiation monotherapy.
Academic Article Inherited Susceptibility to Hematopoietic Malignancies in the Era of Precision Oncology.
Academic Article The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
Academic Article A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias.
Academic Article Feasibility and limitations of cultured skin fibroblasts for germline genetic testing in hematologic disorders.
Academic Article Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.
Academic Article Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Academic Article Revision of RUNX1 variant curation rules.
Academic Article International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data.
Academic Article Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.
Academic Article Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages.
Academic Article Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies.
Academic Article DDX41-associated susceptibility to myeloid neoplasms.
Academic Article Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.
Academic Article Significance of hereditary gene alterations for the pathogenesis of adult bone marrow failure versus myeloid neoplasia.
Academic Article Classification of rare pediatric myeloid neoplasia-Quo vadis?
Academic Article Prioritization of patients for germline testing based on tumor profiling of hematopoietic malignancies.
Academic Article (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.
Grant Myeloid Malignancy Variant Curation Expert Panel
Grant The Role of DNMT3B in the DNA Methylation of Cancer Cells
Grant A chemical crosslinking strategy to determine DNA methylating protein complexes
Grant Epigenetic and Genetic Dissection of Drug Response
Academic Article Germline loss-of-function BRCA1 and BRCA2 mutations and risk of de novo hematopoietic malignancies.
Academic Article Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.
Academic Article Germ line risk variants: beyond cancer.
Academic Article Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation.
Academic Article Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT.
Academic Article Sequential tumor molecular profiling identifies likely germline variants.
Academic Article Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.
Academic Article Evaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population.
Academic Article Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.
Academic Article Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders.
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