| Item Type | Name |
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Concept
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Genetic Vectors
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Concept
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Genetics, Medical
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Concept
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Polymorphism, Genetic
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Concept
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Transcription, Genetic
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Concept
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Genetic Variation
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Concept
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Genetic Association Studies
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Concept
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Genetic Diseases, Inborn
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Concept
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Databases, Genetic
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Concept
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Promoter Regions, Genetic
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Concept
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Epigenomics
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Concept
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Crosses, Genetic
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Concept
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Enhancer Elements, Genetic
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Concept
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Epistasis, Genetic
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Concept
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Genetic Counseling
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Concept
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Genetic Testing
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Concept
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Translocation, Genetic
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Concept
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Genetic Predisposition to Disease
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Concept
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Epigenesis, Genetic
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Academic Article
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The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model.
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Academic Article
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Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.
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Academic Article
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Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins.
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Academic Article
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Therapy-related myeloid leukemia.
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Academic Article
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Deletion of the der(9q) in chronic myeloid leukemia: the controversy continues.
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Academic Article
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The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma.
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Academic Article
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Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines.
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Academic Article
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Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage.
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Academic Article
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The use of hypomethylating agents in the treatment of hematologic malignancies.
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Academic Article
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DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.
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Academic Article
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Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: are we there yet?
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Academic Article
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Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
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Academic Article
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Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.
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Academic Article
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The histone code and treatments for acute myeloid leukemia.
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Academic Article
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Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma.
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Academic Article
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Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.
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Academic Article
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An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
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Academic Article
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Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.
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Academic Article
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Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.
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Academic Article
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5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
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Academic Article
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Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis.
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Academic Article
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Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia.
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Academic Article
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High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis.
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Academic Article
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Perspectives and future directions for epigenetics in hematology.
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Academic Article
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Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits.
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Academic Article
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Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
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Academic Article
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Proposal for the clinical detection and management of patients and their family members with familial myelodysplastic syndrome/acute leukemia predisposition syndromes.
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Academic Article
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Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells.
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Academic Article
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Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.
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Academic Article
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TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
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Academic Article
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Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma.
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Academic Article
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New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.
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Academic Article
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Inherited predisposition to acute myeloid leukemia.
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Academic Article
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DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
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Academic Article
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A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia.
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Academic Article
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Large conserved domains of low DNA methylation maintained by Dnmt3a.
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Academic Article
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The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
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Academic Article
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Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes.
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Academic Article
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A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies.
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Academic Article
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Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations.
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Academic Article
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On the origin of leukemic species.
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Academic Article
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Linking the genetic architecture of cytosine modifications with human complex traits.
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Academic Article
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TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.
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Academic Article
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Characterization of CpG sites that escape methylation on the inactive human X-chromosome.
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Academic Article
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DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
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Academic Article
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Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
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Academic Article
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Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.
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Academic Article
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Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation.
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Academic Article
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Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
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Academic Article
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Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
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Academic Article
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Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC).
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Academic Article
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Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes.
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Academic Article
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Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy.
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Academic Article
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Genetic predisposition to leukemia and other hematologic malignancies.
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Academic Article
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How I diagnose and manage individuals at risk for inherited myeloid malignancies.
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Academic Article
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Germline ETV6 mutations and predisposition to hematological malignancies.
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Academic Article
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Genetic predisposition to hematologic malignancies: management and surveillance.
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Academic Article
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Recognition of familial myeloid neoplasia in adults.
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Academic Article
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Therapy-related myeloid neoplasms: when genetics and environment collide.
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Academic Article
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Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies.
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Academic Article
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Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.
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Academic Article
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Hereditary Myelodysplastic Syndrome and Acute Myeloid Leukemia: Diagnosis, Questions, and Controversies.
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Academic Article
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MBD4: guardian of the epigenetic galaxy.
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Academic Article
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Identifying patients with genetic predisposition to acute myeloid leukemia.
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Academic Article
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Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways.
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Academic Article
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Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes.
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Academic Article
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Somatic mutation panels: Time to clear their names.
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Academic Article
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FouNdER mutations confer risk for leukemias.
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Academic Article
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Inherited predisposition to myeloid malignancies.
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Academic Article
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ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.
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Academic Article
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5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
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Academic Article
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How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies.
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Academic Article
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RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.
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Academic Article
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Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome.
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Academic Article
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Inherited Thrombocytopenia Caused by Germline ANKRD26 Mutation Should Be Considered in Young Patients With Suspected Myelodysplastic Syndrome.
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Academic Article
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Assessment of technical heterogeneity among diagnostic tests to detect germline risk variants for hematopoietic malignancies.
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Academic Article
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Regulation of telomeric function by DNA methylation differs between humans and mice.
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Academic Article
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Identifying potential germline variants from sequencing hematopoietic malignancies.
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Academic Article
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Identifying potential germline variants from sequencing hematopoietic malignancies.
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Academic Article
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Germline mutations in MDS/AML predisposition disorders.
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Academic Article
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Germline variants drive myelodysplastic syndrome in young adults.
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Academic Article
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Inherited predisposition to haematopoietic malignancies: overcoming barriers and exploring opportunities.
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Academic Article
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Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer.
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Academic Article
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RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function.
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Academic Article
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Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model.
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Academic Article
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Clinical features and survival outcomes in patients with chronic myelomonocytic leukemia arising in the context of germline predisposition syndromes.
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Academic Article
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Germline predisposition to hematopoietic malignancies.
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Academic Article
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Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites.
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Academic Article
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Genetics of Myelodysplastic Syndromes.
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Academic Article
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Therapy-related myeloid neoplasms in 109 patients after radiation monotherapy.
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Academic Article
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Inherited Susceptibility to Hematopoietic Malignancies in the Era of Precision Oncology.
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Academic Article
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A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias.
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Academic Article
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Feasibility and limitations of cultured skin fibroblasts for germline genetic testing in hematologic disorders.
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Academic Article
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Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.
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Academic Article
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Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
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Academic Article
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Revision of RUNX1 variant curation rules.
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Academic Article
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MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia.
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Academic Article
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Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages.
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Grant
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The Role of DNMT3B in the DNA Methylation of Cancer Cells
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Grant
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A chemical crosslinking strategy to determine DNA methylating protein complexes
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Grant
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Epigenetic and Genetic Dissection of Drug Response
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Academic Article
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Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation.
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Academic Article
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Sequential tumor molecular profiling identifies likely germline variants.
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Academic Article
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Evaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population.
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Academic Article
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Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.
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Academic Article
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Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders.
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