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Adams, Erin J.
One or more keywords matched the following properties of Adams, Erin J.
PropertyValue
keywords structural biology
overview Our laboratory is interested in the molecular signals that are used by the immune system to distinguish healthy from unhealthy tissue. Many of our projects focus on “unconventional” T cell recognition, involving ?d T cells, Natural Killer T cells and Muscosal-Associated Invariant T (MAIT) cells and antigen presentation by nonclassical or MHC-like proteins. Our strengths are in biochemistry, structural biology, protein engineering and cellular assays that will reveal the fundamental principles behind how effector cells of the immune system regulate human disease. We have a high level of expertise in studying molecular recognition of T cells, particularly unconventional T cells outside the canonical CD4+/CD8+ lineage and structure function of antigen-presenting molecules.
One or more keywords matched the following items that are connected to Adams, Erin J.
Item TypeName
Concept Receptors, Cell Surface
Concept Receptors, Antigen, B-Cell
Concept Receptors, Immunologic
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Receptor-CD3 Complex, Antigen, T-Cell
Concept Receptors, NK Cell Lectin-Like
Concept Receptors, KIR2DL4
Concept Receptors, Natural Killer Cell
Concept NK Cell Lectin-Like Receptor Subfamily C
Concept NK Cell Lectin-Like Receptor Subfamily A
Concept Receptors, Antigen, T-Cell
Concept Receptors, Virus
Concept Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Concept Computational Biology
Concept NK Cell Lectin-Like Receptor Subfamily D
Concept Receptors, KIR
Academic Article Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.
Academic Article The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.
Academic Article ?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion.
Academic Article The molecular basis for modulation of human V?9Vd2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Academic Article The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR.
Academic Article Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes.
Academic Article NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the coevolution of killer cell Ig-like receptors with MHC-C.
Academic Article A T cell receptor goes public.
Academic Article Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
Academic Article Antigen recognition determinants of gammadelta T cell receptors.
Academic Article How the T cell receptor sees antigen--a structural view.
Academic Article High-level bacterial secretion of single-chain alphabeta T-cell receptors.
Academic Article Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.
Academic Article Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
Academic Article Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells.
Academic Article An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells.
Academic Article Evolution of the V, D, and J gene segments used in the primate gammadelta T-cell receptor reveals a dichotomy of conservation and diversity.
Academic Article Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human ?d T-cell subset.
Academic Article The yin and yang of CD1d recognition.
Academic Article The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins.
Academic Article Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires.
Academic Article Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor.
Academic Article The molecular basis for recognition of CD1d/a-galactosylceramide by a human non-Va24 T cell receptor.
Academic Article Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
Academic Article Diverse antigen presentation by the Group 1 CD1 molecule, CD1c.
Academic Article Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by aß T cells.
Academic Article The CD3 conformational change in the ?d T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
Academic Article Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4.
Academic Article MAIT recognition of a stimulatory bacterial antigen bound to MR1.
Academic Article Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells.
Academic Article The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V?9Vd2 T cells.
Academic Article Introduction to Cellular Immunology Special Issue on ?d T cells.
Academic Article Human gamma delta T cells: Evolution and ligand recognition.
Academic Article Coevolution of T-cell receptors with MHC and non-MHC ligands.
Academic Article Molecular Analysis of Lipid-Reactive Vd1 ?d T Cells Identified by CD1c Tetramers.
Academic Article RhoB Mediates Phosphoantigen Recognition by V?9Vd2 T Cell Receptor.
Academic Article MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.
Academic Article Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.
Academic Article V?9Vd2 T cell activation by strongly agonistic nucleotidic phosphoantigens.
Academic Article Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1.
Academic Article Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V?9Vd2 T cell activation.
Academic Article Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins.
Academic Article MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.
Academic Article Generation and molecular recognition of melanoma-associated antigen-specific human ?d T cells.
Academic Article Casting a wider net: Immunosurveillance by nonclassical MHC molecules.
Academic Article TCR-pMHC bond conformation controls TCR ligand discrimination.
Academic Article Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive V?9Vd2 T cell subset.
Academic Article Diversity in recognition and function of human ?d T cells.
Academic Article Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops.
Academic Article Molecular design of the ?dT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.
Academic Article How Tim proteins differentially exploit membrane features to attain robust target sensitivity.
Academic Article The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
Academic Article Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.
Concept Hepatitis A Virus Cellular Receptor 2
Concept Hepatitis A Virus Cellular Receptor 1
Concept Leukocyte Immunoglobulin-like Receptor B1
Academic Article CRISPR screens decode cancer cell pathways that trigger ?d T cell detection.
Academic Article Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells.
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  • Receptor
  • Biology