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Sisodia, Sangram S.

One or more keywords matched the following items that are connected to Sisodia, Sangram S.

Item Type	Name
Concept	Mice, Transgenic
Academic Article	Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Academic Article	Transgenic models of neurodegenerative diseases.
Academic Article	Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.
Academic Article	Loss of functional prion protein: a role in prion disorders?
Academic Article	Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Academic Article	A vector for expressing foreign genes in the brains and hearts of transgenic mice.
Academic Article	Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease.
Academic Article	Inherited neurodegenerative diseases and transgenic models.
Academic Article	Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.
Academic Article	Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
Academic Article	Alzheimer's disease: genetic studies and transgenic models.
Academic Article	An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
Academic Article	ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.
Academic Article	Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models.
Academic Article	Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
Academic Article	Genetic neurodegenerative diseases: the human illness and transgenic models.
Academic Article	Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
Academic Article	Mutant genes in familial Alzheimer's disease and transgenic models.
Academic Article	Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
Academic Article	Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems.
Academic Article	Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine.
Academic Article	Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Academic Article	The value of transgenic models for the study of neurodegenerative diseases.
Academic Article	Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.
Academic Article	Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.
Academic Article	Function and dysfunction of the presenilins.
Academic Article	Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.
Academic Article	Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.
Academic Article	Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
Academic Article	Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Academic Article	Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
Academic Article	APP processing and synaptic function.
Academic Article	True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice.
Academic Article	Presenilin-1-dependent transcriptome changes.
Academic Article	Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
Academic Article	Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice.
Academic Article	Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex.
Academic Article	Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).
Academic Article	Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
Academic Article	P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.
Academic Article	Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice.
Academic Article	Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Academic Article	Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Academic Article	Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.
Academic Article	Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
Academic Article	An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria.
Academic Article	Cellular and molecular biology of Alzheimer's disease and animal models.
Academic Article	Amyloid beta amyloidosis in Alzheimer's disease.
Academic Article	Cellular and molecular biology of Alzheimer's disease and animal models.
Academic Article	Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected].
Academic Article	Alzheimer's disease-type brain abnormalities in animal models.
Academic Article	Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
Academic Article	APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
Academic Article	Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.
Academic Article	Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.
Academic Article	Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors.
Academic Article	Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons.
Academic Article	Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.
Academic Article	Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article	Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
Academic Article	Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Academic Article	An APP ectodomain mutation outside of the Aß domain promotes Aß production in vitro and deposition in vivo.
Academic Article	Gut microbiota-driven brain Aß amyloidosis in mice requires microglia.
Academic Article	ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.
Academic Article	Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease.
Academic Article	The gut microbiome regulates astrocyte reaction to Aß amyloidosis through microglial dependent and independent mechanisms.
Academic Article	Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome.
Academic Article	Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.

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Mice Transgenic