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One or more keywords matched the following properties of Awad, Issam
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overview Awad was recruited in 2010 to lead the Neurovascular Surgery Program at the University of Chicago Medicine, and is currently tenured in the Biological Sciences Division. He is the John Harper Seeley Professor of Neurological Sciences and Professor of Neurological Surgery, Neurology, the Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, and the (PhD granting) Committee on Neurobiology. He is a Senior Faculty Scholar at the Bucksbaum Institute for Clinical Excellence and directs the Safadi Program of Excellence in Clinical and Translational Neurosciences. Dr Awad is active in numerous professional and learned societies. He has served on the Executive Committee of the American Stroke Association, and on the Board of Governors of the American College of Surgeons. He was the Chairman of the Joint Cerebrovascular Section of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons, he has directed the Annual Course on Research Update in Neuroscience for Neurosurgeons, and he served as the 51st President of the Congress of Neurological Surgeons. Dr Awad is the Founding past-President of the World Association of Lebanese Neurosurgeons, and the Founding Chairman of Scientific Advisory Board of the patient advocacy group Angioma Alliance. Dr Awad has authored over 350 scientific papers and book chapters, and edited twelve books dealing with cerebrovascular surgery and other aspects of neurological surgery. He has presented over 500 papers and lectures at major meetings and symposia, has been a visiting professor at numerous institutions in the United States and abroad, was recognized among America’s Best Doctors, Best Teachers, and is the recipient of the Bucy Award for Excellence in Neurosurgical Education, the Arnold Award for Mentoring at Pritzker School of Medicine, and numerous other honors. Dr Awad has made numerous scientific contributions including the characterization of subcortical ischemic lesions in the aged, advances in the understanding of the natural history and biologic behavior of vascular malformations of the brain, numerous technical advances in neurovascular and epilepsy surgery, and is a recognized expert in the treatment of neurovascular disease, hemorrhagic stroke and neurosurgical critical care. His research has been cited by other researchers more than 79,000 times (H-index 91). Current research focuses on molecular mechanisms, biomarkers and therapeutic targets in cavernous angiomas (cerebral vascular malformations), the pathobiology of brain hemorrhage, and minimally invasive techniques for treating hemorrhagic stroke. Dr. Awad's research has been funded continuously from the National Institutes of Health since 1998, including a prestigious midcareer development grant in patient-oriented research (2000-2005), and current active R01, P01 and U01 funding through 2025. From 2016 to 2020, he served on the United States National Advisory Council for Neurological Disorders and Stroke. In 2019, he was elected to the Association of American Physicians. www.issamawad.com www.uchicagomedicine.org/ccm www.uchicagomedicine.org/hht http://safadiprogram.uchicago.edu
One or more keywords matched the following items that are connected to Awad, Issam
Item TypeName
Concept Hemangioma
Concept Hemangioma, Cavernous
Concept Hemangioma, Capillary
Concept Hemangioma, Cavernous, Central Nervous System
Academic Article Mixed vascular malformations of the brain: clinical and pathogenetic considerations.
Academic Article Comparison of the clinical presentation of symptomatic arteriovenous malformations (angiographically visualized) and occult vascular malformations.
Academic Article Intracranial cavernous malformations: lesion behavior and management strategies.
Academic Article A founder mutation as a cause of cerebral cavernous malformation in Hispanic Americans.
Academic Article A comparison of the clinical profile of cavernous malformations with and without associated venous malformations.
Academic Article Multiple vertebral hemangiomas with neurological signs. Case report.
Academic Article Ultrastructural pathological features of cerebrovascular malformations: a preliminary report.
Academic Article Further study of CD31 protein and messenger ribonucleic acid expression in human cerebral vascular malformations.
Academic Article Multiple spinal cavernous malformations with atypical phenotype after prior irradiation: case report.
Academic Article Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion.
Academic Article Differential gene expression in human cerebrovascular malformations.
Academic Article Mutational analysis of 206 families with cavernous malformations.
Academic Article Spectrum of genotype and clinical manifestations in cerebral cavernous malformations.
Academic Article Hemorrhage from cavernous malformations of the brain: definition and reporting standards. Angioma Alliance Scientific Advisory Board.
Academic Article Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models.
Academic Article Oligoclonal immune response in cerebral cavernous malformations. Laboratory investigation.
Academic Article Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.
Academic Article A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
Academic Article A "pseudo-cavernoma" - an encapsulated hematoma of the choroid plexus.
Academic Article Cavernous malformations.
Academic Article Vascular pressures and cortical blood flow in cavernous angioma of the brain.
Academic Article From mutant mice to "vascular permeability therapy" in cavernous angiomas?
Academic Article Fatal "hypertensive" intracerebral hemorrhage associated with a cerebral cavernous angioma: case report.
Academic Article Magnetic resonance imaging evaluation of cerebral cavernous malformations with susceptibility-weighted imaging.
Academic Article Cerebral cavernous malformations: clinical insights from genetic studies.
Academic Article Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21.
Academic Article Pathological heterogeneity of angiographically occult vascular malformations of the brain.
Academic Article Radiosurgery and venous malformations.
Academic Article Brainstem cavernous malformations.
Academic Article Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution.
Academic Article Genetic heterogeneity of inherited cerebral cavernous malformation.
Academic Article Natural history of the cavernous angioma.
Academic Article Advanced magnetic resonance imaging of cerebral cavernous malformations: part I. High-field imaging of excised human lesions.
Academic Article Biology of vascular malformations of the brain.
Academic Article Vascular malformations and epilepsy: clinical considerations and basic mechanisms.
Academic Article Intracranial cavernous angioma: a practical review of clinical and biological aspects.
Academic Article Cerebral cavernous malformations and epilepsy.
Academic Article Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review.
Academic Article What genes can teach us about human cerebrovascular malformations.
Academic Article Evaluation of iron content in human cerebral cavernous malformation using quantitative susceptibility mapping.
Academic Article Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations.
Academic Article Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.
Academic Article Brainstem cavernous malformations: 1390 surgical cases from the literature.
Academic Article Dynamic permeability and quantitative susceptibility: related imaging biomarkers in cerebral cavernous malformations.
Academic Article Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.
Academic Article Vascular permeability in cerebral cavernous malformations.
Academic Article Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.
Academic Article Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.
Academic Article B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models.
Academic Article Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
Academic Article RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
Academic Article Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations.
Academic Article Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Academic Article The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation.
Academic Article Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.
Academic Article Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage.
Academic Article Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.
Academic Article Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH).
Academic Article Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations.
Academic Article Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
Academic Article Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth.
Academic Article Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Academic Article A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis.
Academic Article Biomarkers of cavernous angioma with symptomatic hemorrhage.
Academic Article A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
Academic Article Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations.
Academic Article Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Academic Article Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature.
Academic Article Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation.
Academic Article Stereotactic laser interstitial thermal therapy for epilepsy associated with solitary and multiple cerebral cavernous malformations.
Academic Article Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance.
Academic Article Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu.
Academic Article Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma.
Academic Article Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation.
Academic Article Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Academic Article Propranolol inhibits cavernous vascular malformations by ß1 adrenergic receptor antagonism in animal models.
Academic Article A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).
Academic Article PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Academic Article Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations.
Academic Article Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage.
Academic Article Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation.
Academic Article Cerebral Cavernous Malformation: From Mechanism to Therapy.
Academic Article Commentary: Feasibility and Morbidity of Magnetic Resonance Imaging-Guided Stereotactic Laser Ablation of Deep Cerebral Cavernous Malformations: A Report of 4 Cases.
Academic Article COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation.
Academic Article Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project.
Academic Article Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth.
Academic Article Propranolol as therapy for cerebral cavernous malformations: a cautionary note.
Academic Article Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease.
Academic Article Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma.
Grant Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)
Grant Development of BA-1049 for treatment of cerebral cavernous malformation
Academic Article Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation.
Academic Article Cavernous Angioma Symptomatic Hemorrhage (CASH) Trial Readiness II: Imaging Biomarkers and Trial Modeling.
Academic Article Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling.
Academic Article Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome.
Academic Article Transcriptomic signatures of individual cell types in cerebral cavernous malformation.
Academic Article Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.
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  • Hemangioma