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Viral Nonstructural Proteins
Concept
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Randall, Glenn C.
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Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy.
Academic Article
Why?
Calcium-dependent calpain proteases are implicated in processing of the hepatitis C virus NS5A protein.
Academic Article
Why?
Controlling protein function with HCV protease.
Academic Article
Why?
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.
Academic Article
Why?
Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides.
Academic Article
Why?
Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis.
Academic Article
Why?
Distinct activation phenotype of a highly conserved novel HLA-B57-restricted epitope during dengue virus infection.
Academic Article
Why?
Expression of immunoreactive forms of the hepatitis C NS5A protein in E. coli and their use for diagnostic assays.
Academic Article
Why?
Hepatitis C virus (HCV) NS5A protein downregulates HCV IRES-dependent translation.
Academic Article
Why?
Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication.
Academic Article
Why?
High-resolution functional profiling of a gammaherpesvirus RTA locus in the context of the viral genome.
Academic Article
Why?
Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus.
Academic Article
Why?
Influenza virus NS1- C/EBPß gene regulatory complex inhibits RIG-I transcription.
Academic Article
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