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Glenn C. Randall

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMicrobiology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Our laboratory investigates the roles of virus-host interactions in replication and pathogenesis. We study RNA viruses, including hepatitis C virus, dengue virus, Zika virus, and noroviruses. These are medically important viruses, causing cirrhosis/liver cancer, hemorrhagic fever, birth defects, and severe GI disease, respectively.

    We have identified ~100 host cofactors of viral replication. We now study the importance of these cellular genes in diverse steps of the viral life cycle, including entry, the regulation of viral protein translation and RNA replication, modulation of cellular lipid metabolism, the establishment of viral replication complexes, the secretion of infectious virus, and control of infection by the innate immune system.

    Collapse Biography 
    Collapse education and training
    University of Illinois, Urbana, ILB.S.05/1993Microbiology
    The University of Chicago, Chicago, ILPh.D.12/1999Virology
    Rockefeller University, New York, NYPostdoc07/2005Virology
    Collapse awards and honors
    1993 - 1995National Research Service Award, NIH
    2002 - 2005Postdoctoral Fellow, American Cancer Society
    2006Outstanding New Investigator Award, NIH DDRCC
    2007 - 2009Career Development Award, Schweppe Foundation
    2007 - 2008Herman Lopata Hepatitis C Liver Scholar, American Liver Foundation
    2008 - 2011Career Development Award, NIH GLRCE
    2010 - 2014Research Scholar, American Cancer Society
    2011Investigator in the Pathogenesis of Infectious Disease Finalist, Burroughs Wellcome Fund

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Almubarak HF, Tan W, Hoffmann AD, Wei J, El-Shennawy L, Squires JR, Sun Y, Dashzeveg NK, Simonton B, Jia Y, Iyer R, Xu Y, Nicolaescu V, Elli D, Randall GC, Schipma MJ, Swaminathan S, Ison MG, Liu H, Fang D, Shen Y, Almubarak HF, Tan W, Hoffmann AD, Sun Y, Wei J, El-Shennawy L, Squires JR, Dashzeveg NK, Simonton B, Jia Y, Iyer R, Xu Y, Nicolaescu V, Elli D, Randall GC, Schipma MJ, Swaminathan S, Ison MG, Liu H, Fang D, Shen Y, Shen Y. Novel antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy. bioRxiv. 2024 Aug 20. PMID: 38496411; PMCID: PMC10942297.
      Citations:    
    2. Cianfarini C, Hassler L, Wysocki J, Hassan A, Nicolaescu V, Elli D, Gula H, Ibrahim AM, Randall G, Henkin J, Batlle D. Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant. Cells. 2024 Jan 23; 13(3). PMID: 38334597; PMCID: PMC10854654.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. So CW, Sourisseau M, Sarwar S, Evans MJ, Randall G. Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids. PLoS Pathog. 2023 Dec; 19(12):e1011887. PMID: 38157366; PMCID: PMC10756512.
      Citations: 2     Fields:    Translation:HumansCells
    4. Kurhade C, Kang S, Biering SB, Hwang S, Randall G. CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. mBio. 2023 06 27; 14(3):e0017223. PMID: 37052473; PMCID: PMC10294620.
      Citations: 1     Fields:    Translation:HumansAnimals
    5. Nicolaescu V, Tomatsidou A, Gula H, Randall G, Missiakas D, Hassler L, Wysocki J, Ahrendsen JT, Ye M, Gelarden I, Cianfarini C, Forster P, Khurram N, Singer BD, Henkin J, Batlle D. Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection. Life Sci Alliance. 2023 07; 6(7). PMID: 37041017; PMCID: PMC10098141.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Hassler L, Wysocki J, Ahrendsen JT, Ye M, Gelarden I, Nicolaescu V, Tomatsidou A, Gula H, Cianfarini C, Khurram N, Kanwar Y, Singer BD, Randall G, Missiakas D, Henkin J, Batlle D. Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection. bioRxiv. 2022 Dec 06. PMID: 36523403; PMCID: PMC9753780.
      Citations:    
    7. Emanuelson C, Ankenbruck N, Kumbhare R, Thomas M, Connelly C, Baktash Y, Randall G, Deiters A. Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells. J Med Chem. 2022 12 22; 65(24):16338-16352. PMID: 36449366; PMCID: PMC9942140.
      Citations: 3     Fields:    Translation:HumansCells
    8. Zhou Y, Liu Y, Gupta S, Paramo MI, Hou Y, Mao C, Luo Y, Judd J, Wierbowski S, Bertolotti M, Nerkar M, Jehi L, Drayman N, Nicolaescu V, Gula H, Tay S, Randall G, Wang P, Lis JT, Erzurum SC, Cheng F, Yu H, Feschotte C. A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Nat Biotechnol. 2023 01; 41(1):128-139. PMID: 36217030; PMCID: PMC9851973.
      Citations: 55     Fields:    Translation:HumansCells
    9. Nguyen LC, Renner DM, Silva D, Yang D, Parenti NA, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR, Stock L. SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 10 26; 13(5):e0241522. PMID: 36125275; PMCID: PMC9600248.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    10. Nguyen LC, Renner DM, Silva D, Yang D, Parenti N, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR, Stock L. SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells. bioRxiv. 2022 Jun 13. PMID: 35821981; PMCID: PMC9275661.
      Citations:    
    11. Zhou Y, Liu Y, Gupta S, Paramo MI, Hou Y, Mao C, Luo Y, Judd J, Wierbowski S, Bertolotti M, Nerkar M, Jehi L, Drayman N, Nicolaescu V, Gula H, Tay S, Randall G, Lis JT, Erzurum SC, Cheng F, Yu H, Feschotte C. A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19. Res Sq. 2022 Jun 07. PMID: 35677070; PMCID: PMC9176654.
      Citations: 1     
    12. Schor S, Pu S, Nicolaescu V, Azari S, Karim M, Cassonnet P, Saul S, Neveu G, Yueh A, Demeret C, Skotheim JM, Jacob Y, Randall G, Einav S, Kõivomägi M. The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection. J Biol Chem. 2022 06; 298(6):101956. PMID: 35452674; PMCID: PMC9133654.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    13. Lian Q, Zhang K, Zhang Z, Duan F, Guo L, Luo W, Mok BW, Thakur A, Ke X, Motallebnejad P, Nicolaescu V, Chen J, Ma CY, Zhou X, Han S, Han T, Zhang W, Tan AY, Zhang T, Wang X, Xu D, Xiang J, Xu A, Liao C, Huang FP, Chen YW, Na J, Randall G, Tse HF, Chen Z, Chen Y, Chen HJ. Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nat Commun. 2022 04 19; 13(1):2028. PMID: 35440562; PMCID: PMC9018716.
      Citations: 37     Fields:    Translation:HumansCells
    14. Hassler L, Wysocki J, Gelarden I, Sharma I, Tomatsidou A, Ye M, Gula H, Nicoleascu V, Randall G, Pshenychnyi S, Khurram N, Kanwar Y, Missiakas D, Henkin J, Yeldandi A, Batlle D. A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection. J Am Soc Nephrol. 2022 07; 33(7):1293-1307. PMID: 35236774; PMCID: PMC9257820.
      Citations: 24     Fields:    Translation:AnimalsCells
    15. Nguyen LC, Yang D, Nicolaescu V, Best TJ, Gula H, Saxena D, Gabbard JD, Chen SN, Ohtsuki T, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Robinson-Mailman L, Valdespino A, Jones KA, Azizi SA, Demarco JK, Severson WE, Anderson CD, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Palmer KE, National COVID Cohort Collaborative Consortium, Meltzer DO, Randall G, Rosner MR, Stock L, Suárez E. Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. Sci Adv. 2022 Feb 25; 8(8):eabi6110. PMID: 35050692.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    16. El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2. Nat Commun. 2022 01 20; 13(1):405. PMID: 35058437; PMCID: PMC8776790.
      Citations: 81     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. Cai X, Chen M, Prominski A, Lin Y, Ankenbruck N, Rosenberg J, Nguyen M, Shi J, Tomatsidou A, Randall G, Missiakas D, Fung J, Chang EB, Penaloza-MacMaster P, Tian B, Huang J. A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2. Adv Sci (Weinh). 2022 01; 9(2):e2103240. PMID: 34761549; PMCID: PMC8646742.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    18. Gray LT, Raczy MM, Briquez PS, Marchell TM, Alpar AT, Wallace RP, Volpatti LR, Sasso MS, Cao S, Nguyen M, Mansurov A, Budina E, Watkins EA, Solanki A, Mitrousis N, Reda JW, Yu SS, Tremain AC, Wang R, Nicolaescu V, Furlong K, Dvorkin S, Manicassamy B, Randall G, Wilson DS, Kwissa M, Swartz MA, Hubbell JA. Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant. Biomaterials. 2021 11; 278:121159. PMID: 34634664; PMCID: PMC8482845.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    19. Volpatti LR, Wallace RP, Cao S, Raczy MM, Wang R, Gray LT, Alpar AT, Briquez PS, Mitrousis N, Marchell TM, Sasso MS, Nguyen M, Mansurov A, Budina E, Solanki A, Watkins EA, Schnorenberg MR, Tremain AC, Reda JW, Nicolaescu V, Furlong K, Dvorkin S, Yu SS, Manicassamy B, LaBelle JL, Tirrell MV, Randall G, Kwissa M, Swartz MA, Hubbell JA. Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity. ACS Cent Sci. 2021 Aug 25; 7(8):1368-1380. PMID: 34466656; PMCID: PMC8315245.
      Citations: 14     
    20. Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S, Muñoz-Alía MÁ. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science. 2021 08 20; 373(6557):931-936. PMID: 34285133; PMCID: PMC8809056.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    21. Chen M, Rosenberg J, Cai X, Lee ACH, Shi J, Nguyen M, Wignakumar T, Mirle V, Edobor AJ, Fung J, Donington JS, Shanmugarajah K, Lin Y, Chang E, Randall G, Penaloza-MacMaster P, Tian B, Madariaga ML, Huang J. Nanotraps for the containment and clearance of SARS-CoV-2. Matter. 2021 Jun 02; 4(6):2059-2082. PMID: 33907732; PMCID: PMC8062026.
      Citations: 22     
    22. Volpatti LR, Wallace RP, Cao S, Raczy MM, Wang R, Gray LT, Alpar AT, Briquez PS, Mitrousis N, Marchell TM, Sasso MS, Nguyen M, Mansurov A, Budina E, Solanki A, Watkins EA, Schnorenberg MR, Tremain AC, Reda JW, Nicolaescu V, Furlong K, Dvorkin S, Yu SS, Manicassamy B, LaBelle JL, Tirrell MV, Randall G, Kwissa M, Swartz MA, Hubbell JA. Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity. bioRxiv. 2021 Apr 08. PMID: 33851166; PMCID: PMC8043456.
      Citations:    
    23. Hassler L, Wysocki J, Gelarden I, Tomatsidou A, Gula H, Nicoleascu V, Randall G, Henkin J, Yeldandi A, Batlle D. A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection. bioRxiv. 2021 Mar 15. PMID: 33758841; PMCID: PMC7987000.
      Citations: 1     
    24. Nguyen LC, Yang D, Nicolaescu V, Best TJ, Ohtsuki T, Chen SN, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Gula H, Jones KA, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Meltzer DO, Randall G, Rosner MR. Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response. bioRxiv. 2021 Mar 10. PMID: 33758843; PMCID: PMC7987002.
      Citations: 1     
    25. Kim Y, Wower J, Maltseva N, Chang C, Jedrzejczak R, Wilamowski M, Kang S, Nicolaescu V, Randall G, Michalska K, Joachimiak A. Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol. 2021 02 09; 4(1):193. PMID: 33564093; PMCID: PMC7873276.
      Citations: 73     Translation:HumansCells
    26. Osipiuk J, Azizi SA, Dvorkin S, Endres M, Jedrzejczak R, Jones KA, Kang S, Kathayat RS, Kim Y, Lisnyak VG, Maki SL, Nicolaescu V, Taylor CA, Tesar C, Zhang YA, Zhou Z, Randall G, Michalska K, Snyder SA, Dickinson BC, Joachimiak A. Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors. Nat Commun. 2021 02 02; 12(1):743. PMID: 33531496; PMCID: PMC7854729.
      Citations: 202     Fields:    Translation:HumansCells
    27. Wysocki J, Ye M, Hassler L, Gupta AK, Wang Y, Nicoleascu V, Randall G, Wertheim JA, Batlle D. A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids. J Am Soc Nephrol. 2021 Apr; 32(4):795-803. PMID: 33526471; PMCID: PMC8017551.
      Citations: 57     Fields:    
    28. So CW, Randall G. Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus. Viruses. 2021 01 30; 13(2). PMID: 33573191; PMCID: PMC7911643.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    29. Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Miskey C, Herder V, Lauber C, Tarr AW, McClure CP, Randall G, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Rice CM, Pietschmann T, Gerold G, Ströh LJ, Ivics Z, Baumgärtner W, Seifert M, Baktash Y, Goedecke N, Wirth D. Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice. Sci Adv. 2020 11; 6(45). PMID: 33148654; PMCID: PMC7673688.
      Citations: 13     Fields:    Translation:AnimalsCells
    30. Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S, Muñoz-Alía MÁ. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv. 2020 Sep 01. PMID: 32908976; PMCID: PMC7480023.
      Citations: 3     
    31. Furlong K, Biering SB, Choi J, Wilen CB, Orchard RC, Wobus CE, Nelson CA, Fremont DH, Baldridge MT, Randall G, Hwang S. CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner. J Virol. 2020 08 17; 94(17). PMID: 32581099; PMCID: PMC7431780.
      Citations: 2     Fields:    Translation:AnimalsCells
    32. Ketter E, Randall G. Virus Impact on Lipids and Membranes. Annu Rev Virol. 2019 09 29; 6(1):319-340. PMID: 31567065.
      Citations: 57     Fields:    Translation:AnimalsCells
    33. Zhang Z, He G, Filipowicz NA, Randall G, Belov GA, Kopek BG, Wang X. Host Lipids in Positive-Strand RNA Virus Genome Replication. Front Microbiol. 2019; 10:286. PMID: 30863375; PMCID: PMC6399474.
      Citations: 74     
    34. Baktash Y, Randall G. Live Cell Imaging of Hepatitis C Virus Trafficking in Hepatocytes. Methods Mol Biol. 2019; 1911:263-274. PMID: 30593632; PMCID: PMC7021324.
      Citations: 2     Fields:    Translation:HumansCells
    35. Kincaid RP, Lam VL, Chirayil RP, Randall G, Sullivan CS. RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):8197-8202. PMID: 30038017; PMCID: PMC6094126.
      Citations: 27     Fields:    Translation:HumansCells
    36. Randall G. Lipid Droplet Metabolism during Dengue Virus Infection. Trends Microbiol. 2018 08; 26(8):640-642. PMID: 29909044.
      Citations: 26     Fields:    Translation:HumansCells
    37. Baktash Y, Madhav A, Coller KE, Randall G. Single Particle Imaging of Polarized Hepatoma Organoids upon Hepatitis C Virus Infection Reveals an Ordered and Sequential Entry Process. Cell Host Microbe. 2018 03 14; 23(3):382-394.e5. PMID: 29544098; PMCID: PMC7169308.
      Citations: 57     Fields:    Translation:HumansCells
    38. Xiao F, Wang S, Barouch-Bentov R, Neveu G, Pu S, Beer M, Schor S, Kumar S, Nicolaescu V, Lindenbach BD, Randall G, Einav S. Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release. mBio. 2018 03 13; 9(2). PMID: 29535204; PMCID: PMC5850324.
      Citations: 17     Fields:    Translation:HumansCells
    39. Jordan TX, Randall G. Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy. J Virol. 2017 06 01; 91(11). PMID: 28298606; PMCID: PMC5432877.
      Citations: 62     Fields:    Translation:HumansCells
    40. Bekerman E, Neveu G, Shulla A, Brannan J, Pu SY, Wang S, Xiao F, Barouch-Bentov R, Bakken RR, Mateo R, Govero J, Nagamine CM, Diamond MS, De Jonghe S, Herdewijn P, Dye JM, Randall G, Einav S. Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects. J Clin Invest. 2017 Apr 03; 127(4):1338-1352. PMID: 28240606; PMCID: PMC5373883.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    41. Jordan TX, Randall G. Flavivirus modulation of cellular metabolism. Curr Opin Virol. 2016 08; 19:7-10. PMID: 27280383; PMCID: PMC5021554.
      Citations: 31     Fields:    Translation:HumansCells
    42. Shulla A, Randall G. (+) RNA virus replication compartments: a safe home for (most) viral replication. Curr Opin Microbiol. 2016 08; 32:82-88. PMID: 27253151; PMCID: PMC4983521.
      Citations: 48     Fields:    Translation:Cells
    43. Zhang J, Zhang Z, Chukkapalli V, Nchoutmboube JA, Li J, Randall G, Belov GA, Wang X. Positive-strand RNA viruses stimulate host phosphatidylcholine synthesis at viral replication sites. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):E1064-73. PMID: 26858414; PMCID: PMC4776486.
      Citations: 67     Fields:    Translation:AnimalsCells
    44. Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, von Schaewen M, Heller B, Vercauteren K, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T, Zeilinger C, Luxenburger E, Kirschning A, Müller R. Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1. Hepatology. 2016 Jan; 63(1):49-62. PMID: 26248546; PMCID: PMC4688136.
      Citations: 43     Fields:    Translation:HumansCells
    45. Shulla A, Randall G. Spatiotemporal analysis of hepatitis C virus infection. PLoS Pathog. 2015 Mar; 11(3):e1004758. PMID: 25822891; PMCID: PMC4378894.
      Citations: 30     Fields:    Translation:HumansCells
    46. Chukkapalli V, Berger KL, Kelly SM, Thomas M, Deiters A, Randall G. Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides. Virology. 2015 Feb; 476:168-179. PMID: 25546252; PMCID: PMC4323755.
      Citations: 14     Fields:    Translation:HumansCells
    47. Chukkapalli V, Randall G. Hepatitis C virus replication compartment formation: mechanism and drug target. Gastroenterology. 2014 May; 146(5):1164-7. PMID: 24675576; PMCID: PMC7003645.
      Citations: 3     Fields:    Translation:HumansCells
    48. Dolan PT, Zhang C, Khadka S, Arumugaswami V, Vangeloff AD, Heaton NS, Sahasrabudhe S, Randall G, Sun R, LaCount DJ. Identification and comparative analysis of hepatitis C virus-host cell protein interactions. Mol Biosyst. 2013 Dec; 9(12):3199-209. PMID: 24136289; PMCID: PMC4171131.
      Citations: 22     Fields:    Translation:HumansCells
    49. Schoggins JW, Randall G. Lipids in innate antiviral defense. Cell Host Microbe. 2013 Oct 16; 14(4):379-85. PMID: 24139397; PMCID: PMC3850052.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    50. Czaja MJ, Ding WX, Donohue TM, Friedman SL, Kim JS, Komatsu M, Lemasters JJ, Lemoine A, Lin JD, Ou JH, Perlmutter DH, Randall G, Ray RB, Tsung A, Yin XM. Functions of autophagy in normal and diseased liver. Autophagy. 2013 Aug; 9(8):1131-58. PMID: 23774882; PMCID: PMC3748187.
      Citations: 237     Fields:    Translation:HumansAnimals
    51. Oakland TE, Haselton KJ, Randall G. EWSR1 binds the hepatitis C virus cis-acting replication element and is required for efficient viral replication. J Virol. 2013 Jun; 87(12):6625-34. PMID: 23552423; PMCID: PMC3676111.
      Citations: 21     Fields:    Translation:HumansCells
    52. Shulla A, Randall G. Hepatitis C virus-host interactions, replication, and viral assembly. Curr Opin Virol. 2012 Dec; 2(6):725-32. PMID: 23083892; PMCID: PMC3508086.
      Citations: 25     Fields:    Translation:HumansCells
    53. Chukkapalli V, Heaton NS, Randall G. Lipids at the interface of virus-host interactions. Curr Opin Microbiol. 2012 Aug; 15(4):512-8. PMID: 22682978; PMCID: PMC3424344.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    54. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bourquin JP, Boya P, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, Ghosh P, Giammarioli AM, Giatromanolaki AN, Gibson SB, Gilkerson RW, Ginger ML, Ginsberg HN, Golab J, Goligorsky MS, Golstein P, Gomez-Manzano C, Goncu E, Gonzalez CD, Gonzalez R, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
      Citations: 1819     Fields:    Translation:HumansAnimals
    55. Coller KE, Heaton NS, Berger KL, Cooper JD, Saunders JL, Randall G. Molecular determinants and dynamics of hepatitis C virus secretion. PLoS Pathog. 2012 Jan; 8(1):e1002466. PMID: 22241992; PMCID: PMC3252379.
      Citations: 104     Fields:    Translation:HumansCells
    56. Polyak SJ, Morishima C, Scott JD, Gastaminza P, Cox A, Higgs MR, Loo YM, Golden-Mason L, Lindenbach BD, Baumert TF, Randall G, Gale M, de Araújo ES. A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses. Gastroenterology. 2012 Jan; 142(1):e1-5. PMID: 22185796.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    57. Jordan TX, Randall G. Manipulation or capitulation: virus interactions with autophagy. Microbes Infect. 2012 Feb; 14(2):126-39. PMID: 22051604; PMCID: PMC3264745.
      Citations: 54     Fields:    Translation:HumansCells
    58. Khadka S, Vangeloff AD, Zhang C, Siddavatam P, Heaton NS, Wang L, Sengupta R, Sahasrabudhe S, Randall G, Gribskov M, Kuhn RJ, Perera R, LaCount DJ. A physical interaction network of dengue virus and human proteins. Mol Cell Proteomics. 2011 Dec; 10(12):M111.012187. PMID: 21911577; PMCID: PMC3237087.
      Citations: 81     Fields:    Translation:HumansCells
    59. Heaton NS, Randall G. Dengue virus and autophagy. Viruses. 2011 08; 3(8):1332-41. PMID: 21994782; PMCID: PMC3185800.
      Citations: 72     Fields:    Translation:HumansCells
    60. Berger KL, Kelly SM, Jordan TX, Tartell MA, Randall G. Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication. J Virol. 2011 Sep; 85(17):8870-83. PMID: 21697487; PMCID: PMC3165839.
      Citations: 103     Fields:    Translation:HumansCells
    61. Heaton NS, Randall G. Multifaceted roles for lipids in viral infection. Trends Microbiol. 2011 Jul; 19(7):368-75. PMID: 21530270; PMCID: PMC3130080.
      Citations: 177     Fields:    Translation:Cells
    62. Heaton NS, Randall G. Dengue virus-induced autophagy regulates lipid metabolism. Cell Host Microbe. 2010 Nov 18; 8(5):422-32. PMID: 21075353; PMCID: PMC3026642.
      Citations: 390     Fields:    Translation:HumansAnimalsCells
    63. Heaton NS, Perera R, Berger KL, Khadka S, Lacount DJ, Kuhn RJ, Randall G. Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17345-50. PMID: 20855599; PMCID: PMC2951450.
      Citations: 295     Fields:    Translation:HumansAnimalsCells
    64. Berger KL, Randall G. Possibilities for RNA interference in developing hepatitis C virus therapeutics. Viruses. 2010 Aug; 2(8):1647-1665. PMID: 21994699; PMCID: PMC3185727.
      Citations: 2     Fields:    
    65. Coller KE, Berger KL, Heaton NS, Cooper JD, Yoon R, Randall G. RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. PLoS Pathog. 2009 Dec; 5(12):e1000702. PMID: 20041214; PMCID: PMC2790617.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    66. Berger KL, Randall G. Potential roles for cellular cofactors in hepatitis C virus replication complex formation. Commun Integr Biol. 2009 Nov; 2(6):471-3. PMID: 20195453; PMCID: PMC2829822.
      Citations: 18     
    67. Berger KL, Cooper JD, Heaton NS, Yoon R, Oakland TE, Jordan TX, Mateu G, Grakoui A, Randall G. Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7577-82. PMID: 19376974; PMCID: PMC2678598.
      Citations: 205     Fields:    Translation:HumansCells
    68. Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C. Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet. 2007 Oct; 81(4):829-34. PMID: 17847008; PMCID: PMC2227932.
      Citations: 176     Fields:    Translation:HumansCells
    69. Randall G, Panis M, Cooper JD, Tellinghuisen TL, Sukhodolets KE, Pfeffer S, Landthaler M, Landgraf P, Kan S, Lindenbach BD, Chien M, Weir DB, Russo JJ, Ju J, Brownstein MJ, Sheridan R, Sander C, Zavolan M, Tuschl T, Rice CM. Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12884-9. PMID: 17616579; PMCID: PMC1937561.
      Citations: 290     Fields:    Translation:HumansCells
    70. Te HS, Randall G, Jensen DM. Mechanism of action of ribavirin in the treatment of chronic hepatitis C. Gastroenterol Hepatol (N Y). 2007 Mar; 3(3):218-25. PMID: 21960835; PMCID: PMC3099343.
      Citations: 68     
    71. Randall G, Chen L, Panis M, Fischer AK, Lindenbach BD, Sun J, Heathcote J, Rice CM, Edwards AM, McGilvray ID. Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection. Gastroenterology. 2006 Nov; 131(5):1584-91. PMID: 17101330.
      Citations: 82     Fields:    Translation:HumansCells
    72. Sewer A, Lagos-Quintana M, Sheridan R, Sander C, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T, Pfeffer S, Grässer FA. Identification of microRNAs of the herpesvirus family. Nat Methods. 2005 Apr; 2(4):269-76. PMID: 15782219.
      Citations: 581     Fields:    Translation:Cells
    73. Chen YL, Graham MD, de Pablo JJ, Randall GC, Gupta M, Doyle PS. Conformation and dynamics of single DNA molecules in parallel-plate slit microchannels. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Dec; 70(6 Pt 1):060901. PMID: 15697334.
      Citations: 21     Fields:    Translation:Cells
    74. Randall G, Rice CM. Interfering with hepatitis C virus RNA replication. Virus Res. 2004 Jun 01; 102(1):19-25. PMID: 15068876.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    75. Zhang J, Randall G, Higginbottom A, Monk P, Rice CM, McKeating JA. CD81 is required for hepatitis C virus glycoprotein-mediated viral infection. J Virol. 2004 Feb; 78(3):1448-55. PMID: 14722300; PMCID: PMC321402.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    76. Randall G, Grakoui A, Rice CM. Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):235-40. PMID: 12518066; PMCID: PMC140937.
      Citations: 105     Fields:    Translation:HumansCells
    77. Randall G, Lagunoff M, Roizman B. Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice. J Virol. 2000 Oct; 74(19):9019-27. PMID: 10982346; PMCID: PMC102098.
      Citations: 11     Fields:    Translation:AnimalsCells
    78. Randall G, Roizman B. Transcription of the derepressed open reading frame P of herpes simplex virus 1 precludes the expression of the antisense gamma(1)34.5 gene and may account for the attenuation of the mutant virus. J Virol. 1997 Oct; 71(10):7750-7. PMID: 9311860; PMCID: PMC192127.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    79. Randall G, Lagunoff M, Roizman B. The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10379-84. PMID: 9294219; PMCID: PMC23371.
      Citations: 26     Fields:    Translation:AnimalsCells
    80. Lagunoff M, Randall G, Roizman B. Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene. J Virol. 1996 Mar; 70(3):1810-7. PMID: 8627705; PMCID: PMC190008.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
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