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Arachidonate 15-Lipoxygenase
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Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.
Academic Article
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Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.
Academic Article
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Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet ß cells.
Academic Article
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Inhibition of 12/15-Lipoxygenase Protects Against ß-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.
Academic Article
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Mirmira, Raghu
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Tersey, Sarah
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12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.
Academic Article
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Anderson, Ryan
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Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.
Academic Article
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12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
Academic Article
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Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.
Academic Article
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Barreiro, Luis
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