Arachidonate 15-Lipoxygenase
"Arachidonate 15-Lipoxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.
| Descriptor ID |
D001093
|
| MeSH Number(s) |
D08.811.682.690.416.583.500.065 D12.776.556.579.374.568.500.030
|
| Concept/Terms |
Arachidonate 15-Lipoxygenase- Arachidonate 15-Lipoxygenase
- 15-Lipoxygenase, Arachidonate
- Arachidonate 15 Lipoxygenase
- Arachidonic Acid 15-Lipoxygenase
- 15-Lipoxygenase, Arachidonic Acid
- Arachidonic Acid 15 Lipoxygenase
- 15-Lipoxygenase
- 15 Lipoxygenase
|
Below are MeSH descriptors whose meaning is more general than "Arachidonate 15-Lipoxygenase".
Below are MeSH descriptors whose meaning is more specific than "Arachidonate 15-Lipoxygenase".
This graph shows the total number of publications written about "Arachidonate 15-Lipoxygenase" by people in this website by year, and whether "Arachidonate 15-Lipoxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Arachidonate 15-Lipoxygenase" by people in Profiles.
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12-Lipoxygenase Inhibition Improves Glycemia and Obesity-associated Inflammation in Male Human Gene Replacement Mice. Endocrinology. 2025 Apr 22; 166(6).
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12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice. JCI Insight. 2024 Dec 20; 9(24).
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Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Nature. 2023 02; 614(7948):530-538.
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12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes. JCI Insight. 2021 07 22; 6(14).
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Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet ß cells. J Biol Chem. 2019 04 19; 294(16):6612-6620.
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Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications. Pharmacol Ther. 2019 03; 195:100-110.
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Inhibition of 12/15-Lipoxygenase Protects Against ß-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes. Diabetes. 2017 11; 66(11):2875-2887.
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12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets. Mol Cell Biol. 2014 Oct 01; 34(19):3735-45.
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Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One. 2013; 8(2):e56763.
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Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. Diabetes. 2008 Jan; 57(1):199-208.