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Staley, Jonathan P.
One or more keywords matched the following properties of Staley, Jonathan P.
PropertyValue
keywords Pre-mRNA
overview Our goal is to understand the mechanism and regulation of nuclear pre-mRNA splicing, an essential step in eukaryotic gene expression. Pre-mRNA splicing is catalyzed by a massive multimegadalton ribonucleoprotein machine called the spliceosome. Using the model organism S. cerevisiae as well as human cells, we apply a wide array of approaches, ranging from single molecule microscopy, biophysics, and chemical biology to biochemistry and cell biology to genetics and genomics to gain a deep understanding of how the spliceosome catalyzes and regulates pre-mRNA splicing, including in the context of transcription.
One or more keywords matched the following items that are connected to Staley, Jonathan P.
Item TypeName
Concept RNA Precursors
Academic Article An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
Academic Article The splicing factor Prp43p, a DEAH box ATPase, functions in ribosome biogenesis.
Academic Article U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing.
Academic Article Long-distance splicing.
Academic Article The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase.
Academic Article Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.
Academic Article Spliceosome discards intermediates via the DEAH box ATPase Prp43p.
Academic Article Staying on message: ensuring fidelity in pre-mRNA splicing.
Academic Article The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing.
Academic Article A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Academic Article Splicing fidelity: DEAD/H-box ATPases as molecular clocks.
Academic Article RNA catalyses nuclear pre-mRNA splicing.
Academic Article Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events.
Academic Article Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites.
Academic Article The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA.
Academic Article Termination of pre-mRNA splicing requires that the ATPase and RNA unwindase Prp43p acts on the catalytic snRNA U6.
Search Criteria
  • Pre mRNA