| Item Type | Name |
|
Concept
|
Mice, Inbred C3H
|
|
Concept
|
Mice, Inbred Strains
|
|
Concept
|
Mice, Inbred AKR
|
|
Concept
|
Mice, Transgenic
|
|
Concept
|
Mice, Inbred BALB C
|
|
Concept
|
Mice, Inbred C57BL
|
|
Concept
|
Mice, Inbred DBA
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
Mice, Inbred MRL lpr
|
|
Concept
|
Mice
|
|
Concept
|
Mice, Mutant Strains
|
|
Concept
|
Mice, SCID
|
|
Academic Article
|
PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.
|
|
Academic Article
|
Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.
|
|
Academic Article
|
The mechanism of somatic hypermutation studied with transgenic and transfected target genes.
|
|
Academic Article
|
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.
|
|
Academic Article
|
N region diversity of a transgenic substrate in fetal and adult lymphoid cells.
|
|
Academic Article
|
Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.
|
|
Academic Article
|
Identification and characterization of the murine Rag1 promoter.
|
|
Academic Article
|
Gamma 2b provides only some of the signals normally given via mu in B cell development.
|
|
Academic Article
|
Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.
|
|
Academic Article
|
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.
|
|
Academic Article
|
Immunoglobulin transgenes as targets for somatic hypermutation.
|
|
Academic Article
|
The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences.
|
|
Academic Article
|
Rearrangement and expression of immunoglobulin genes in transgenic mice.
|
|
Academic Article
|
Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.
|
|
Academic Article
|
A linkage map of distal mouse chromosome 4 in the vicinity of Ssm1, a strain-specific modifier of methylation.
|
|
Academic Article
|
An efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection.
|
|
Academic Article
|
Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.
|
|
Academic Article
|
A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.
|
|
Academic Article
|
Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.
|
|
Academic Article
|
A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.
|
|
Academic Article
|
Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.
|
|
Academic Article
|
Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends.
|
|
Academic Article
|
Effects of sequence and structure on the hypermutability of immunoglobulin genes.
|
|
Academic Article
|
Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.
|
|
Academic Article
|
A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.
|
|
Academic Article
|
Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.
|
|
Academic Article
|
A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes.
|
|
Academic Article
|
The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription.
|
|
Academic Article
|
Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
|
|
Academic Article
|
Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading.
|
|
Academic Article
|
Identification and localization of an enhancer for the human lambda L chain Ig gene complex.
|
|
Academic Article
|
Immunology. Autoreactive B cells migrate into T cell territory.
|
|
Academic Article
|
Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.
|
|
Academic Article
|
Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.
|
|
Academic Article
|
Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice.
|
|
Academic Article
|
The published data.
|
|
Academic Article
|
Factors affecting the rearrangement efficiency of an Ig test gene.
|
|
Academic Article
|
Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.
|
|
Academic Article
|
Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination.
|
|
Academic Article
|
Differential splicing of thymosin beta 4 mRNA.
|
|
Academic Article
|
Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
|
|
Academic Article
|
A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci.
|
|
Academic Article
|
Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils.
|
|
Academic Article
|
Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
|
|
Academic Article
|
Analysis of somatic mutations in kappa transgenes.
|
|
Academic Article
|
Expression of immunoglobulin and globin genes in B and T lymphocytes and other cells.
|
|
Academic Article
|
Antibodies of different immunoglobulin classes released by single cells.
|
|
Academic Article
|
The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.
|
|
Academic Article
|
Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice.
|
|
Academic Article
|
Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice.
|
|
Academic Article
|
Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.
|
|
Academic Article
|
Antibody production by host cells in x-irradiated recipients of allogeneic spleen cells.
|
|
Academic Article
|
Quantitation of immunoglobulin genes by nucleic acid hybridization with RNA from myeloma and spleen microsomes.
|
|
Academic Article
|
Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".
|
|
Academic Article
|
Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
|
|
Academic Article
|
Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression.
|
|
Academic Article
|
Rearrangement of immunoglobulin genes.
|
|
Academic Article
|
Strain-specific transgene methylation occurs early in mouse development and can be recapitulated in embryonic stem cells.
|
|
Academic Article
|
Kinetics of mouse spleen cell populations during the immune response.
|
|
Academic Article
|
Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.
|
|
Academic Article
|
Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA.
|
|
Academic Article
|
Direct demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization.
|
|
Academic Article
|
Synthesis of specific RNA molecules during immune response in the mouse spleen.
|
|
Academic Article
|
Immunoglobulin genes in DNA restriction fragments.
|
|
Academic Article
|
Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.
|
|
Academic Article
|
Somatic mutation of immunoglobulin light-chain variable-region genes.
|
|
Academic Article
|
Association of two different repetitive DNA elements near immunoglobulin light chain genes.
|
|
Academic Article
|
Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development.
|
|
Academic Article
|
lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.
|
|
Academic Article
|
Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes.
|
|
Academic Article
|
Transgenic mice with immunoglobulin genes.
|
|
Academic Article
|
The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns.
|
|
Academic Article
|
Immunoglobulin messenger RNAs of T lymphocytes.
|
|
Academic Article
|
Fusion of a scid pre-B cells with a wild type (myeloma) B cell results in correct rearrangement of a V(D)J recombination substrate.
|
|
Academic Article
|
Immunoglobulin mu- and gamma-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice.
|
|
Academic Article
|
Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.
|
|
Academic Article
|
Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice.
|
|
Academic Article
|
RNA sequences homologous to the 3' portion of immunoglobulin alpha-chain mRNA in thymus-derived lymphocytes.
|
|
Academic Article
|
Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain.
|
|
Academic Article
|
Evolution of mouse immunoglobulin lambda genes.
|
|
Academic Article
|
Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage.
|
|
Academic Article
|
Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.
|
|
Academic Article
|
Number and activity of free and membrane-bound spleen ribosomes during the course of the immune response.
|
|
Academic Article
|
Ultrastructure of rosette-forming cells in the mouse during the antibody response.
|
|
Academic Article
|
Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells.
|
|
Academic Article
|
Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
|
|
Academic Article
|
Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.
|
|
Academic Article
|
Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.
|
|
Academic Article
|
The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status.
|
|
Academic Article
|
Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.
|
|
Academic Article
|
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.
|
|
Academic Article
|
The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation.
|
|
Academic Article
|
Molecular aspects of somatic hypermutation of immunoglobulin genes.
|
|
Academic Article
|
The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.
|
|
Academic Article
|
Immunoglobulin genes: generating diversity with AID and UNG.
|
|
Academic Article
|
The transcription factor Spi-B is not required for somatic hypermutation.
|
|
Academic Article
|
DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1.
|
|
Academic Article
|
Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement.
|
|
Academic Article
|
The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.
|
|
Academic Article
|
Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.
|
|
Academic Article
|
The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.
|
|
Academic Article
|
Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.
|
|
Academic Article
|
Expression of immunoglobulin genes in transgenic mice and transfected cells.
|
|
Academic Article
|
Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
|
|
Academic Article
|
B cells expressing Ig transgenes respond to a T-dependent antigen only in the presence of Ia-compatible T cells.
|
|
Academic Article
|
Pre-B cells in kappa-transgenic mice.
|
|
Academic Article
|
Coexistence of 19S and 7S hemolysins in splenic foci.
|
|
Academic Article
|
Immunoglobulin gene rearrangements in hybridoma cells.
|
|
Academic Article
|
High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.
|
|
Academic Article
|
Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.
|
|
Academic Article
|
Immunoglobulin synthesis by T cells: quantitative and qualitative aspects.
|
|
Academic Article
|
Evidence for multiple immunoglobulin genes.
|
|
Academic Article
|
Influence of metabolic inhibitors on the capacity of spleen cells to form hemolytic plaques and rosettes.
|
|
Academic Article
|
Why does somatic hypermutation by AID require transcription of its target genes?
|
|
Academic Article
|
Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis.
|
|
Academic Article
|
Ssm1b expression and function in germ cells of adult mice and in early embryos.
|
|
Grant
|
CONTROL OF IMMUNOGLOBULIN SYNTHESIS
|
|
Grant
|
CONTROL OF IMMUNOGLOBULIN SYNTHESIS
|
|
Grant
|
EXPRESSION OF IMMUNOGLOBULIN GENES IN TRANSGENIC MICE
|
|
Grant
|
CONTROL OF IMMUNOGLOBULIN SYNTHESIS
|
|
Grant
|
MUTATION OF IG GENES
|
|
Grant
|
Mechanism of Immunoglobulin Hypermutation
|
|
Grant
|
AID in somatic mutation of immunoglobulin genes
|
|
Grant
|
Immunoglobulin Somatic Mutation
|
|
Grant
|
Identification of the DNA methylation/chromatin modifier Ssm1
|
|
Grant
|
EXPRESSION OF IMMUNOGLOBULIN GENES
|