Item Type | Name |
Concept
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Diabetes Mellitus, Experimental
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Concept
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Diabetes Mellitus, Type 1
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Concept
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Diabetes Mellitus, Type 2
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Concept
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Genetics, Population
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Concept
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Diabetes, Gestational
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Concept
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Antisense Elements (Genetics)
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Concept
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Diabetes Complications
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Concept
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Diabetes Mellitus
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Academic Article
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Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6.
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Academic Article
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Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
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Academic Article
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Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase.
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Academic Article
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cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young.
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Academic Article
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Identification of a simple tandem repeat DNA polymorphism in the human glycogen synthase gene and linkage to five markers on chromosome 19q.
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Academic Article
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Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.
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Academic Article
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Linkage and association studies in insulin-dependent diabetes with a new dinucleotide repeat polymorphism at the GAD65 locus.
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Academic Article
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Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity.
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Academic Article
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Glucokinase mutations, insulin secretion, and diabetes mellitus.
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Academic Article
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance.
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Academic Article
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The aggregation of the 5' insulin gene polymorphism in insulin dependent (type I) diabetes mellitus families.
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Academic Article
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Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.
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Academic Article
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Characterization of a third simple tandem repeat polymorphism in the human glucokinase gene.
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Academic Article
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NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity.
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Academic Article
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Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
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Academic Article
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Identification of microsatellite markers near the human genes encoding the beta-cell ATP-sensitive K+ channel and linkage studies with NIDDM in Japanese.
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Academic Article
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Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4.
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Academic Article
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Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle.
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Academic Article
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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes.
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Academic Article
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.
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Academic Article
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Diabetes, dependence, asymptotics, selection and significance.
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Academic Article
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MODY: a model for the study of the molecular genetics of NIDDM.
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Academic Article
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Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha/MODY3 gene in Japanese subjects with early- and late-onset NIDDM.
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Academic Article
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Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).
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Academic Article
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Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM.
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Academic Article
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Maturity onset diabetes of the young (MODY).
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Academic Article
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An approach for identifying simple sequence repeat DNA polymorphisms near cloned cDNAs and genes. Linkage studies of the islet amyloid polypeptide/amylin and liver glycogen synthase genes and NIDDM.
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Academic Article
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Linkage studies in NIDDM with markers near the sulphonylurea receptor gene.
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Academic Article
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Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.
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Academic Article
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Nature or nurture: an insightful illustration from a Chinese family with hepatocyte nuclear factor-1 alpha diabetes (MODY3)
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Academic Article
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
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Academic Article
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Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom.
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Academic Article
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Evidence that insulin is imprinted in the human yolk sac.
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Academic Article
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Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.
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Academic Article
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Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta.
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Academic Article
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Linkage analysis of maturity-onset diabetes of the young with microsatellite polymorphisms. No linkage to ADA or GLUT2 genes in two families.
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Academic Article
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beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.
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Academic Article
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A simple test for the high-frequency P291fsinsC mutation in the HNF1 alpha/MODY3 gene.
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Academic Article
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A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.
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Academic Article
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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
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Academic Article
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Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.
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Academic Article
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Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene.
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Academic Article
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Functional properties of the R154X HNF-4alpha protein generated by a mutation associated with maturity-onset diabetes of the young, type 1.
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Academic Article
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Identification of three missense mutations in the peroxisome proliferator-activated receptor alpha gene in Japanese subjects with maturity-onset diabetes of the young.
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Academic Article
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Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young.
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Academic Article
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Neonatal diabetes mellitus due to complete glucokinase deficiency.
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Academic Article
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Calpains play a role in insulin secretion and action.
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Academic Article
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No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4gamma gene (HNF4G) in Japanese patients with MODY.
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Academic Article
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Improved glucose tolerance and insulin sensitivity after electrical stimulation-assisted cycling in people with spinal cord injury.
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Academic Article
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Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome.
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Academic Article
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Diabetes mellitus and genetically programmed defects in beta-cell function.
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Academic Article
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Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.
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Academic Article
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Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.
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Academic Article
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Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy.
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Academic Article
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Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population.
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Academic Article
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Control of pancreas and liver gene expression by HNF transcription factors.
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Academic Article
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Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus.
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Academic Article
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Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.
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Academic Article
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Mapping genes influencing type 2 diabetes risk and BMI in Japanese subjects.
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Academic Article
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Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.
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Academic Article
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Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
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Academic Article
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Treatment of hyperglycemia in a 7-year-old child diagnosed with neonatal diabetes.
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Academic Article
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Anti-diabetic effect of ginsenoside Re in ob/ob mice.
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Academic Article
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Gene symbol: IPF1. Disease: MODY 4.
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Academic Article
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Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses.
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Academic Article
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Patterns of linkage disequilibrium in the type 2 diabetes gene calpain-10.
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Academic Article
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Phenotypic heterogeneity between different mutations of MODY subtypes and within MODY pedigrees.
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Academic Article
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Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.
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Academic Article
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Insulin gene mutations as a cause of permanent neonatal diabetes.
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Academic Article
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Macrosomia and neonatal hypoglycaemia in RW pedigree subjects with a mutation (Q268X) in the gene encoding hepatocyte nuclear factor 4alpha (HNF4A).
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Academic Article
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Diagnosis and treatment of neonatal diabetes: a United States experience.
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Academic Article
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Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.
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Academic Article
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Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
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Academic Article
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Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population.
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Academic Article
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Update in neonatal diabetes.
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Academic Article
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The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population.
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Academic Article
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From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.
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Academic Article
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Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.
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Academic Article
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Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
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Academic Article
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A brief perspective on insulin production.
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Academic Article
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Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes.
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Academic Article
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Obesity and hyperinsulinemia in a family with pancreatic agenesis and MODY caused by the IPF1 mutation Pro63fsX60.
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Academic Article
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Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice.
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Academic Article
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Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.
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Academic Article
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Neonatal diabetes mellitus: a model for personalized medicine.
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Academic Article
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Onset features and subsequent clinical evolution of childhood diabetes over several years.
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Academic Article
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The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetes.
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Academic Article
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Calpain-10 gene and protein expression in human skeletal muscle: effect of acute lipid-induced insulin resistance and type 2 diabetes.
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Academic Article
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
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Academic Article
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MODY: history, genetics, pathophysiology, and clinical decision making.
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Academic Article
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Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment.
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Academic Article
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Association of the KCNJ11 variant E23K with type 2 diabetes in Indo-Trinidadians.
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Academic Article
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An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers.
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Academic Article
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Characterization of Japanese families with early-onset type 2 (non-insulin dependent) diabetes mellitus and screening for mutations in the glucokinase and mitochondrial tRNA(Leu(UUR)) genes.
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Academic Article
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Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.
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Academic Article
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Identification of two novel amino acid polymorphisms in beta-cell/liver (GLUT2) glucose transporter in Japanese subjects.
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Academic Article
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Compensation in pancreatic beta-cell function in subjects with glucokinase mutations.
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Academic Article
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HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetes.
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Academic Article
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Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.
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Academic Article
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No evidence for mutations in a putative beta-cell ATP-sensitive K+ channel subunit in MODY, NIDDM, or GDM.
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Academic Article
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Clinical characteristics of subjects with a missense mutation in glucokinase.
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Academic Article
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Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects.
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Academic Article
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Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.
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Academic Article
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Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion.
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Academic Article
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Structure and function of ASP, the human homolog of the mouse agouti gene.
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Academic Article
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Mutations of the human glucokinase gene and diabetes mellitus.
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Academic Article
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The population association of glucokinase gene with type 2 (noninsulin-dependent) diabetes mellitus in Chinese.
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Academic Article
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Maturity-onset diabetes of the young.
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Academic Article
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In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.
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Academic Article
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Organization of the human GLUT2 (pancreatic beta-cell and hepatocyte) glucose transporter gene.
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Academic Article
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A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene.
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Academic Article
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A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.
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Academic Article
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Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.
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Academic Article
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Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.
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Academic Article
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Exome sequencing and genetic testing for MODY.
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Academic Article
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Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations.
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Academic Article
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Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K.
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Academic Article
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Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
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Academic Article
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The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, does not contain a major susceptibility locus for NIDDM in 127 non-Hispanic white affected sibships.
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Academic Article
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Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes.
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Academic Article
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Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young.
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Academic Article
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Variation in the calpain-10 gene affects blood glucose levels in the British population.
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Academic Article
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Organ alchemy: producing insulin in the liver.
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Academic Article
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Linkage of calpain 10 to type 2 diabetes: the biological rationale.
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Academic Article
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Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family.
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Academic Article
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Abnormal insulin secretion, not insulin resistance, is the genetic or primary defect of MODY in the RW pedigree.
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Academic Article
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Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies.
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Academic Article
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Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.
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Academic Article
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Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
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Academic Article
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Three Strikes and You're Cured.
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Academic Article
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Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.
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Academic Article
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Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.
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Academic Article
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Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B.
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Academic Article
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Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family.
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Academic Article
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Molecular genetics of myeloid leukemia: identification of the commonly deleted segment of chromosome 20.
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Academic Article
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Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin.
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Academic Article
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In vitro scan for enhancers at the TCF7L2 locus.
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Academic Article
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Role of BH3-only molecules Bim and Puma in ß-cell death in Pdx1 deficiency.
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Academic Article
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Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications.
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Academic Article
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Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder.
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Academic Article
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Genetics and pathophysiology of neonatal diabetes mellitus.
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Academic Article
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GSK-3ß function in bone regulates skeletal development, whole-body metabolism, and male life span.
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Academic Article
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Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice.
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Academic Article
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Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
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Academic Article
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Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin.
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Academic Article
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Sex and the spread of retrotransposon Ty3 in experimental populations of Saccharomyces cerevisiae.
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Academic Article
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Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.
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Academic Article
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Localization of hepatocyte nuclear factor-4a in the nucleolus and nucleus is regulated by its C-terminus.
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Academic Article
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Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.
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Academic Article
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
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Academic Article
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Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia.
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Academic Article
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Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism.
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Academic Article
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Beyond type 2 diabetes, obesity and hypertension: an axis including sleep apnea, left ventricular hypertrophy, endothelial dysfunction, and aortic stiffness among Mexican Americans in Starr County, Texas.
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Academic Article
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Resting beta-cells - A functional reserve?
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Academic Article
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The genetic architecture of type 2 diabetes.
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Academic Article
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Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
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Academic Article
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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
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Academic Article
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In vivo measurement and biological characterisation of the diabetes-associated mutant insulin p.R46Q (GlnB22-insulin).
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Award or Honor Receipt
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Manpei Suzuki International Prize for Diabetes Research
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Award or Honor Receipt
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The Banting Medal for Scientific Achievement of the American Diabetes Association
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Academic Article
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Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.
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Academic Article
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Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
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Academic Article
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A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
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Academic Article
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Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
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Academic Article
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Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
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Academic Article
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In celebration of a century with insulin - Update of insulin gene mutations in diabetes.
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Academic Article
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Insight on Diagnosis and Treatment From Over a Decade of Research Through the University of Chicago Monogenic Diabetes Registry.
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Grant
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GENES FOR NON-INSULIN-DEPENDENT DIABETES MELLITUS
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Grant
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MOLECULAR MECHANISMS/BETA CELL DYSFUNCTION IN DIABETES
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Grant
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Diabetes Research and Training Center
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Grant
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Diabetes Research and Training Center
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Grant
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GENES RESPONSIBLE IN INSULIN-DEPENDENT DIABETES MELLITUS
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Grant
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A Fly Model of Complex Protein Misfolding Disease
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Grant
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Functional follow-up of the association between TCF7L2 and T2D
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Grant
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Transcriptional Regulatory Networks in Pancreatic Islets
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Academic Article
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Implementing genetic testing in diabetes: Knowledge, perceptions of healthcare professionals, and barriers in a developing country.
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