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Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.
Role of the C-terminal G3 domain in sorting and secretion of aggrecan core protein and ubiquitin-mediated degradation of accumulated mutant precursors.
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Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.
Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics. 2014 Feb; 196(2):539-55.
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PubMed
subject areas
Animals
Animals, Genetically Modified
Cluster Analysis
Diabetes Mellitus
Disease Models, Animal
Drosophila melanogaster
Eye
Female
Gene Dosage
Gene Expression Profiling
Humans
Male
Mutation
Phenotype
Proinsulin
Protein Folding
Quantitative Trait, Heritable
Transcriptome
Transgenes
Wings, Animal
authors with profiles
Michael Z. Ludwig
Martin Kreitman
Soo-Young Park
Louis Philipson
Graeme Bell
Natalia Tamarina