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One or more keywords matched the following properties of Adams, Erin J.
keywords Molecular Immunology
overview Our laboratory is interested in the molecular signals that are used by the immune system to distinguish healthy from unhealthy tissue. Many of our projects focus on “unconventional” T cell recognition, involving ?d T cells, Natural Killer T cells and Muscosal-Associated Invariant T (MAIT) cells and antigen presentation by nonclassical or MHC-like proteins. Our strengths are in biochemistry, structural biology, protein engineering and cellular assays that will reveal the fundamental principles behind how effector cells of the immune system regulate human disease. We have a high level of expertise in studying molecular recognition of T cells, particularly unconventional T cells outside the canonical CD4+/CD8+ lineage and structure function of antigen-presenting molecules.
One or more keywords matched the following items that are connected to Adams, Erin J.
Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Base Sequence
Concept Genes, MHC Class I
Concept Genes, Overlapping
Concept Multigene Family
Concept Models, Molecular
Concept Molecular Sequence Data
Concept Repetitive Sequences, Nucleic Acid
Concept Major Histocompatibility Complex
Concept Sequence Homology, Nucleic Acid
Concept Sequence Homology, Amino Acid
Concept Molecular Mimicry
Concept Evolution, Molecular
Concept Genome, Human
Concept Structural Homology, Protein
Concept Transcriptome
Concept Cloning, Molecular
Concept Conserved Sequence
Concept Polymorphism, Single Nucleotide
Concept Genes, Immunoglobulin Heavy Chain
Concept Molecular Dynamics Simulation
Concept Genetic Loci
Academic Article The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.
Academic Article ?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion.
Academic Article The molecular basis for modulation of human V?9Vd2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Academic Article Episodic evolution and turnover of HLA-B in the indigenous human populations of the Americas.
Academic Article A novel, nonclassical MHC class I molecule specific to the common chimpanzee.
Academic Article Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes.
Academic Article NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the coevolution of killer cell Ig-like receptors with MHC-C.
Academic Article Genomic analysis of common chimpanzee major histocompatibility complex class I genes.
Academic Article Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802].
Academic Article Analysis of a successful immune response against hepatitis C virus.
Academic Article A major histocompatibility complex class I allele shared by two species of chimpanzee.
Academic Article Species-specific evolution of MHC class I genes in the higher primates.
Academic Article Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
Academic Article Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.
Academic Article Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells.
Academic Article Evolution of the V, D, and J gene segments used in the primate gammadelta T-cell receptor reveals a dichotomy of conservation and diversity.
Academic Article The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins.
Academic Article Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires.
Academic Article Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor.
Academic Article The molecular basis for recognition of CD1d/a-galactosylceramide by a human non-Va24 T cell receptor.
Academic Article Evidence for an HLA-C-like locus in the orangutan Pongo pygmaeus.
Academic Article Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes.
Academic Article Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
Academic Article Expression of CD1c enhances human invariant NKT cell activation by a-GalCer.
Academic Article Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by aß T cells.
Academic Article Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4.
Academic Article Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells.
Academic Article High diversity of MIC genes in non-human primates.
Academic Article The origins of HLA-A,B,C polymorphism.
Academic Article The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B alleles.
Academic Article Introduction to Cellular Immunology Special Issue on ?d T cells.
Academic Article Human gamma delta T cells: Evolution and ligand recognition.
Academic Article Coevolution of T-cell receptors with MHC and non-MHC ligands.
Academic Article Molecular Analysis of Lipid-Reactive Vd1 ?d T Cells Identified by CD1c Tetramers.
Academic Article Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.
Academic Article Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1.
Academic Article Generation and molecular recognition of melanoma-associated antigen-specific human ?d T cells.
Academic Article Molecular design of the ?dT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.
Academic Article The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
Academic Article Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.
Concept Molecular Docking Simulation
Search Criteria
  • Molecular
  • Immunology