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One or more keywords matched the following properties of Green, William
keywords Acetylcholine
keywords Acetylcholine Receptors, Nicotinic
overview My research is focused on ionotropic neurotransmitter receptors, the receptors responsible for the rapid postsynaptic response in nerve and muscle. These receptors are large oligomeric membrane proteins with subunits surrounding an ion channel that opens when neurotransmitters bind to the receptor. There are two different families of ionotropic neurotransmitter receptors. One family includes nicotinic acetylcholine receptors (AChRs), GABA and glycine receptors, and the other family are glutamate receptors, both NMDA- and AMPA-type glutamate receptors. The overall goal of my research is to understand how nerve and muscle build these receptors and traffic them specifically to and from synapses. These events regulate the number, density and function of the receptors at synapses, which helps define synaptic strength. The same events underlie learning and memory formation, and when they fail, can contribute to a number of diseases including Alzheimer’s disease, Huntington’s Disease, Myasthenia Gravis and Myasthenic Syndromes. There are several projects ongoing in my lab characterizing the basic cell biology of these receptors, which include receptor assembly, trafficking and clustering. Assembly refers to the processes that transform newly synthesized subunits into functional receptors usually in the endoplasmic reticulum. Trafficking refers to the processes that transport the receptors to and from different location in cells and targets them to these locations. Clustering is the process that packs and maintains the receptors in regions of high density such as synapses. Recently, we have developed new techniques for assaying the protein post-translation modification known as palmitoylation. This work has led to several collaborations in which we are helping to characterize the palmitoylation of a number of different proteins. I also am collaborating with Dr. Paul Selvin (University of Illinois) developing fluorescent single-molecule methods to characterize neurotransmitter receptor subunit composition, stoichiometry and the diffusion/trafficking of these receptors.
One or more keywords matched the following items that are connected to Green, William
Item TypeName
Academic Article Neuronal alpha-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors.
Academic Article The role of the cystine loop in acetylcholine receptor assembly.
Academic Article Formation of the nicotinic acetylcholine receptor binding sites.
Academic Article alpha-bungarotoxin receptors contain alpha7 subunits in two different disulfide-bonded conformations.
Academic Article Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers.
Academic Article Regulation of nicotinic acetylcholine receptor assembly.
Academic Article Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites.
Academic Article Palmitoylation of nicotinic acetylcholine receptors.
Academic Article Rearrangement of nicotinic receptor alpha subunits during formation of the ligand binding sites.
Academic Article The role of palmitoylation in functional expression of nicotinic alpha7 receptors.
Academic Article Counting bungarotoxin binding sites of nicotinic acetylcholine receptors in mammalian cells with high signal/noise ratios.
Academic Article Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning.
Academic Article Acetylcholine receptor assembly: subunit folding and oligomerization occur sequentially.
Academic Article Efficiency of acetylcholine receptor subunit assembly and its regulation by cAMP.
Academic Article Synaptic contact between embryonic neurons and acetylcholine receptor-fibroblast.
Academic Article Development of fluorescence imaging probes for nicotinic acetylcholine a4ß2* receptors.
Academic Article Acetylcholine receptor assembly is stimulated by phosphorylation of its gamma subunit.
Academic Article Analysis of early events in acetylcholine receptor assembly.
Academic Article cAMP stimulation of acetylcholine receptor expression is mediated through posttranslational mechanisms.
Academic Article Fibroblasts transfected with Torpedo acetylcholine receptor beta-, gamma-, and delta-subunit cDNAs express functional receptors when infected with a retroviral alpha recombinant.
Academic Article Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts.
Academic Article The unusual nature of epibatidine responses at the alpha4beta2 nicotinic acetylcholine receptor.
Academic Article Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging.
Concept alpha7 Nicotinic Acetylcholine Receptor
Grant PET imaging of a4b2 nicotinic receptor upregulation and smoking cessation
Grant Different components of nicotine-induced upregulation of nicotinic receptors
Grant The Neuronal alpha-bungarotoxin Binding Site
Academic Article Evaluation of an Image-Derived Input Function for Kinetic Modeling of Nicotinic Acetylcholine Receptor-Binding PET Ligands in Mice.
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  • Acetylcholine