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Search Results to Kay Macleod

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One or more keywords matched the following properties of Macleod, Kay

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keywords Autophagy
overview The deadliest aspect of the majority of human cancers is metastasis, the multi-step process by which cancer cells escape the confines of the primary site (such as breast, pancreas or other organs) and travel in the circulation to distant sites (such as brain, liver or lungs) where they can lodge, invade and grow out as secondary tumors or metastases. Many factors play into cancer metastasis including how disseminating tumor cells respond to stresses such as nutrient deprivation and altered cellular attachments. These stresses are known to activate a process known as autophagy and research in the Macleod Lab seeks to understand and clarify the role of autophagy in tumor growth and progression to metastasis. We are particularly interested in understanding how defects in the turnover of mitochondria (the energy factory of the cell) by mitophagy, leads to tumor invasion and metastasis. Our research addresses how mitophagy is induced and how mitophagy contributes to cellular homeostasis. This includes examining how physiological stresses, such as hypoxia and nutrient deprivation remodel the mitochondrial reticulum, how mitochondrial stress is sensed in the cell and how mitophagy is coordinated with other mitochondrial quality control pathways to promote cellular function. These mechanisms are frequently deregulated in cancers and research in the Macleod Lab also examines how defective mitophagy and mitochondrial dysfunction contributes to tumor progression and metastasis. Mitochondria are highly dynamic organelles and while their function in metabolism and control of apoptosis is well known, work in the Macleod Lab also examines how mitochondria modulate cell fate more broadly, including stemness and in metaplasia, and how they modulate cell motility and invasiveness. This is performed using novel mouse models, engineered cell lines and primary human tumor samples with a focus on breast, pancreas and liver cancers.

One or more keywords matched the following items that are connected to Macleod, Kay

Item TypeName
Academic Article Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3.
Academic Article Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Academic Article Autophagy: assays and artifacts.
Academic Article BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.
Academic Article Autophagy: cellular and molecular mechanisms.
Academic Article Guidelines for the use and interpretation of assays for monitoring autophagy.
Academic Article p62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors.
Academic Article Measuring autophagy in stressed cells.
Academic Article Tumor suppressor functions of BNIP3 and mitophagy.
Academic Article Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Academic Article Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3.
Academic Article Novel insights into how autophagy regulates tumor cell motility.
Academic Article In Brief: Mitophagy: mechanisms and role in human disease.
Academic Article Autophagy in cancer metastasis.
Academic Article Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth.
Academic Article Expanding perspectives on the significance of mitophagy in cancer.
Academic Article Functions of autophagy in the tumor microenvironment and cancer metastasis.
Academic Article Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.
Academic Article Autophagy, cancer stem cells and drug resistance.
Academic Article Autophagy and cancer cell metabolism.
Academic Article BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
Academic Article Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Academic Article Autophagy in major human diseases.

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  • Autophagy