Connection | Profiles RNS

Search Result Details

Back to Search Results

This page shows the details of why an item matched the keywords from your search.

Search Results

Bianco, Antonio

One or more keywords matched the following properties of Bianco, Antonio

Property	Value
overview	Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).

Property

Value

overview

Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).

One or more keywords matched the following items that are connected to Bianco, Antonio

Item Type	Name
Concept	Hormones
Concept	Hormone Antagonists
Concept	Gonadotropin-Releasing Hormone
Concept	Receptors, Thyroid Hormone
Concept	Thyroid Hormones
Concept	Parathyroid Hormone-Related Protein
Concept	Thyroid Hormone Receptors alpha
Concept	Hormone Replacement Therapy
Concept	Thyrotropin-Releasing Hormone
Concept	Thyroid Hormone Receptors beta
Academic Article	American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.
Academic Article	Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Academic Article	Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects.
Academic Article	Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis.
Academic Article	Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.
Academic Article	Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.
Academic Article	Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.
Academic Article	The History and Future of Treatment of Hypothyroidism.
Academic Article	A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons.
Academic Article	Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors.
Academic Article	Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
Academic Article	Type 2 deiodinase at the crossroads of thyroid hormone action.
Academic Article	Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
Academic Article	Adaptive activation of thyroid hormone and energy expenditure.
Academic Article	Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms.
Academic Article	The thyroid hormone-inactivating deiodinase functions as a homodimer.
Academic Article	The role of thyroid hormone and brown adipose tissue in energy homoeostasis.
Academic Article	Thyroid hormone and the neuroglia: both source and target.
Academic Article	Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply.
Academic Article	Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.
Academic Article	Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.
Academic Article	New insights into thyroid hormone replacement therapy.
Academic Article	Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.
Academic Article	Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.
Academic Article	Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism: A Systematic Review and Meta-Analysis.
Academic Article	Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle.
Academic Article	Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.
Academic Article	Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation.
Academic Article	Thyroid hormone signaling in energy homeostasis and energy metabolism.
Academic Article	Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
Academic Article	Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.
Academic Article	Metabolic effects of thyroid hormones-beyond traditional prospects.
Academic Article	Deiodinases: implications of the local control of thyroid hormone action.
Academic Article	Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles.
Academic Article	Thyroid hormone-related regulation of gene expression in human fatty liver.
Academic Article	Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels.
Academic Article	Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide.
Academic Article	For some, L-thyroxine replacement might not be enough: a genetic rationale.
Academic Article	Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse.
Academic Article	Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice.
Academic Article	Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis.
Academic Article	Thyroid hormone replacement therapy: three 'simple' questions, complex answers.
Academic Article	Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold.
Academic Article	A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action.
Academic Article	Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement.
Academic Article	Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity.
Academic Article	The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.
Academic Article	Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.
Academic Article	Coupling between Nutrient Availability and Thyroid Hormone Activation.
Academic Article	Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome.
Academic Article	Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis.
Academic Article	An inside job.
Academic Article	The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
Academic Article	Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency.
Academic Article	Thyroid hormone deiodinases and cancer.
Academic Article	Reawakened interest in type III iodothyronine deiodinase in critical illness and injury.
Academic Article	Conversion of thyroxine (T4) to T3 and rT3 in human leucocyte suspension: its application to clinical investigation.
Academic Article	The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
Academic Article	Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.
Academic Article	A TRbeta-selective agonist confers resistance to diet-induced obesity.
Academic Article	The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion.
Academic Article	Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.
Academic Article	Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton.
Academic Article	Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques.
Academic Article	Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
Academic Article	Minireview: cracking the metabolic code for thyroid hormone signaling.
Academic Article	Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences.
Academic Article	Thyroid function in critically ill patients.
Academic Article	New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism.
Academic Article	The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Academic Article	Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus.
Academic Article	Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.
Academic Article	Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.
Academic Article	Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
Academic Article	Crossing the hurdles of thyroid hormone receptor-a activation.
Academic Article	Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats.
Academic Article	Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells.
Academic Article	Cellular and structural biology of the deiodinases.
Academic Article	An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.
Academic Article	Scope and limitations of iodothyronine deiodinases in hypothyroidism.
Academic Article	Cracking the code for thyroid hormone signaling.
Academic Article	The Deiodinase Trio and Thyroid Hormone Signaling.
Academic Article	Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes.
Academic Article	Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.
Academic Article	3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity.
Academic Article	[Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma].
Academic Article	Paradigms of Dynamic Control of Thyroid Hormone Signaling.
Academic Article	Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Academic Article	Urgent need for further research in subclinical hypothyroidism.
Academic Article	Patient Context and Thyrotropin Levels Are Important When Considering Treatment of Subclinical Hypothyroidism.
Academic Article	Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation.
Academic Article	We All Know We Need Them, We Hope They Are Coming, But When?
Academic Article	Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism.
Academic Article	Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms.
Academic Article	Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?
Academic Article	Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism.
Academic Article	Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling.
Academic Article	Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism.
Academic Article	Accelerating functional gene discovery in osteoarthritis.
Academic Article	Deiodinases and the Metabolic Code for Thyroid Hormone Action.
Academic Article	Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Academic Article	Thyroid Hormone Levels During Hospital Admission Inform Disease Severity and Mortality in COVID-19 Patients.
Academic Article	Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans.
Academic Article	Deiodinase-3 is a thyrostat to regulate podocyte homeostasis.
Academic Article	Response to Letter to the Editor From Bonnema et al: "Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine + Liothyronine in Hypothyroidism".
Academic Article	Brain Fog in Hypothyroidism: Understanding the Patient's Perspective.
Academic Article	Primary hypothyroidism and quality of life.
Academic Article	Suboptimal Thyroid Hormone Replacement Is Associated With Worse Hospital Outcomes.
Academic Article	T3 levels and thyroid hormone signaling.
Academic Article	Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice.
Grant	Characterization of TGR5-D2-WSB1 signaling in metabolic homeostasis in vivo
Grant	Thyroid-adrenergic synergism and adaptive thermogenesis
Grant	Selenodeiodinase processing by the proteasome system
Grant	Selenodeidinase Processing by the Proteasome System
Grant	Metabolic and Xenobiotic Control of Thyroid Hormone Metabolism
Academic Article	Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain.
Academic Article	Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?
Academic Article	Demographic, Healthcare Access, and Dietary Factors Associated With Thyroid Hormone Treatments for Hypothyroidism.
Academic Article	Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism.
Academic Article	Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids.
Academic Article	A Cross-Sectional Analysis of Cardiovascular and Bone Health Care Utilization During Treatment With Thyroid Hormone.
Academic Article	Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
Academic Article	Thyroid hormone homeostasis in levothyroxine-treated patients: Findings from ELSA-Brasil.

Search Criteria

Hormones