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Pamer, Eric
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overview Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.
One or more keywords matched the following items that are connected to Pamer, Eric
Item TypeName
Concept Antigen-Presenting Cells
Concept Bone Marrow Cells
Concept Cell Line, Transformed
Concept Cell Membrane Permeability
Concept Cell Count
Concept Cell Differentiation
Concept Cell Movement
Concept Cell Division
Concept Cell Separation
Concept Clone Cells
Concept Cell Adhesion
Concept Cell Cycle
Concept Cell Wall
Concept Dendritic Cells
Concept Killer Cells, Natural
Concept Mast Cells
Concept Receptors, Cell Surface
Concept Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Concept Schwann Cells
Concept Stem Cells
Concept CHO Cells
Concept Langerhans Cells
Concept Hematopoietic Stem Cell Transplantation
Concept Th1 Cells
Concept Tumor Cells, Cultured
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Stem Cell Transplantation
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Cell Proliferation
Concept Hematopoietic Stem Cell Mobilization
Concept COS Cells
Concept Monocyte-Macrophage Precursor Cells
Concept Receptors, NK Cell Lectin-Like
Concept Vascular Cell Adhesion Molecule-1
Concept Cell Lineage
Concept Cell Line, Tumor
Concept Th17 Cells
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Concept Receptors, Antigen, T-Cell
Concept Mast-Cell Sarcoma
Concept Myeloid Cells
Academic Article Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
Academic Article Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation.
Academic Article Differing roles of inflammation and antigen in T cell proliferation and memory generation.
Academic Article Early programming of T cell populations responding to bacterial infection.
Academic Article Rescue of CD8 T cell-mediated antimicrobial immunity with a nonspecific inflammatory stimulus.
Academic Article Prevention of peritransplantation viridans streptococcal bacteremia with early vancomycin administration: a single-center observational cohort study.
Academic Article Rapid expansion of cytomegalovirus-specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele.
Academic Article Immunology. Giving credit where credit is due.
Academic Article Innate immune activation and CD4+ T cell priming during respiratory fungal infection.
Academic Article Essential yet limited role for CCR2? inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming.
Academic Article Priming of memory but not effector CD8 T cells by a killed bacterial vaccine.
Academic Article Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection.
Academic Article Cuffed and exposed--perp-walking bradyrhizobium.
Academic Article Quantitative studies of CD8+ T-cell responses during microbial infection.
Academic Article Radical host-specific therapies for TB.
Academic Article Promiscuity of MHC class Ib-restricted T cell responses.
Academic Article A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule.
Academic Article Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant.
Academic Article MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection.
Academic Article Voriconazole inhibits fungal growth without impairing antigen presentation or T-cell activation.
Academic Article Immunodominant and subdominant CTL responses to Listeria monocytogenes infection.
Academic Article T lymphocyte dynamics during Listeria monocytogenes infection.
Academic Article Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure.
Academic Article Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment.
Academic Article H2-M3-restricted T cells in bacterial infection: rapid primary but diminished memory responses.
Academic Article T cell responses to bacterial infection.
Academic Article Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.
Academic Article Distinct regulation of H2-M3-restricted memory T cell responses in lymph node and spleen.
Academic Article Distinct CD4+-T-cell responses to live and heat-inactivated Aspergillus fumigatus conidia.
Academic Article From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease.
Academic Article Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands.
Academic Article Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.
Academic Article Monocytes and infection: modulator, messenger and effector.
Academic Article Monocyte-mediated immune defense against murine Listeria monocytogenes infection.
Academic Article Gut Microbiota Predict Pulmonary Infiltrates after Allogeneic Hematopoietic Cell Transplantation.
Academic Article Distinct behavior of myelomonocytic cells and CD8 T cells underlies the hepatic response to Listeria monocytogenes.
Academic Article Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.
Academic Article Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes.
Academic Article Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation.
Academic Article Homeostasis of na?ve, effector and memory CD8 T cells.
Academic Article Role of the commensal microbiota in normal and pathogenic host immune responses.
Academic Article Predictors for persistent cytomegalovirus reactivation after T-cell-depleted allogeneic hematopoietic stem cell transplantation.
Academic Article The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus.
Academic Article H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes.
Academic Article Processing of Listeria monocytogenes antigens and the in vivo T-cell response to bacterial infection.
Academic Article Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.
Academic Article Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus.
Academic Article Quantitation, selection, and functional characterization of Epstein-Barr virus-specific and alloreactive T cells detected by intracellular interferon-gamma production and growth of cytotoxic precursors.
Academic Article Memory phenotype CD8(+) T cells in IL-15 transgenic mice are involved in early protection against a primary infection with Listeria monocytogenes.
Academic Article Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity.
Academic Article Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance.
Academic Article Cracking the fungal armor.
Academic Article CD8 T cell responses to infectious pathogens.
Academic Article Variable immunodominance hierarchies for H2-M3-restricted N-formyl peptides following bacterial infection.
Academic Article Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.
Academic Article CTL epitope generation is tightly linked to cellular proteolysis of a Listeria monocytogenes antigen.
Academic Article Pre- and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients.
Academic Article Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study.
Academic Article Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir.
Academic Article Pathogen-specific CD8 T cell responses are directly inhibited by IL-10.
Academic Article TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus.
Academic Article T cell affinity maturation by selective expansion during infection.
Academic Article Immune responses to Aspergillus fumigatus infections.
Academic Article In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Academic Article Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation.
Academic Article Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model.
Academic Article Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.
Academic Article Do nonclassical, class Ib MHC molecules present bacterial antigens to T cells?
Academic Article Risk factors for late Staphylococcus aureus bacteremia after allogeneic hematopoietic stem cell transplantation: a single-institution, nested case-controlled study.
Academic Article Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies.
Academic Article The role of CD1-restricted T cells in infectious diseases.
Academic Article MHC class I/peptide stability: implications for immunodominance, in vitro proliferation, and diversity of responding CTL.
Academic Article CD8 T cell detection of bacterial infection: sniffing for formyl peptides derived from Mycobacterium tuberculosis.
Academic Article CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.
Academic Article Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8+ T cells.
Academic Article Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.
Academic Article Commensal microbiota affects ischemic stroke outcome by regulating intestinal ?d T cells.
Academic Article Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression.
Academic Article Monocyte recruitment during infection and inflammation.
Academic Article The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation.
Academic Article Control of T cell antigen reactivity via programmed TCR downregulation.
Academic Article In vitro stimulation with WT1 peptide-loaded Epstein-Barr virus-positive B cells elicits high frequencies of WT1 peptide-specific T cells with in vitro and in vivo tumoricidal activity.
Academic Article Aberrant tissue localization of fungus-specific CD4+ T cells in IL-10-deficient mice.
Academic Article Role of intestinal microbiota in transplantation outcomes.
Academic Article MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.
Academic Article Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens.
Academic Article Tipping the balance in favor of protective immunity during influenza virus infection.
Academic Article Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia.
Academic Article Defective CD8+ T cell peripheral tolerance in nonobese diabetic mice.
Academic Article Coordinate regulation of complex T cell populations responding to bacterial infection.
Academic Article Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Academic Article Listeriolysin is processed efficiently into an MHC class I-associated epitope in Listeria monocytogenes-infected cells.
Academic Article Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Academic Article The cellular and molecular origin of tumor-associated macrophages.
Academic Article The fate of low affinity tumor-specific CD8+ T cells in tumor-bearing mice.
Academic Article A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity.
Academic Article Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden.
Academic Article Selective expansion of the monocytic lineage directed by bacterial infection.
Academic Article Cell-mediated immunity: the role of bacterial protein secretion.
Academic Article High-level primary CD8(+) T-cell response to human immunodeficiency virus type 1 gag and env generated by vaccination with recombinant vesicular stomatitis viruses.
Academic Article TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.
Academic Article Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.
Academic Article Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation.
Academic Article Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.
Academic Article Rapid development of T cell memory.
Academic Article Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation.
Academic Article Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection.
Academic Article Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection.
Academic Article Characterization of CD8+ T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas.
Academic Article MHC class Jb-restricted cell responses to Listeria monocytogenes infection.
Academic Article T cell responses to Listeria monocytogenes.
Academic Article Efficiency of MHC class I antigen processing: a quantitative analysis.
Academic Article 2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients.
Academic Article Perforin-deficient CD8+ T cells: in vivo priming and antigen-specific immunity against Listeria monocytogenes.
Academic Article Protective Factors in the Intestinal Microbiome Against Clostridium difficile Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.
Academic Article Disparate in vitro and in vivo requirements for IL-2 during antigen-independent CD8 T cell expansion.
Academic Article Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection.
Academic Article Transmission of Clostridium difficile During Hospitalization for Allogeneic Stem Cell Transplant.
Academic Article Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
Academic Article MHC class I restricted T cell responses to Listeria monocytogenes, an intracellular bacterial pathogen.
Academic Article Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation.
Academic Article Intestinal and splenic T cell responses to enteric Listeria monocytogenes infection: distinct repertoires of responding CD8 T lymphocytes.
Academic Article Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1.
Academic Article TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Academic Article Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.
Academic Article The changing epidemiology of vancomycin-resistant Enterococcus (VRE) bacteremia in allogeneic hematopoietic stem cell transplant (HSCT) recipients.
Academic Article Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.
Academic Article TLR polymorphisms and the risk of invasive fungal infections.
Academic Article Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: a mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes.
Academic Article Effect of antigen-processing efficiency on in vivo T cell response magnitudes.
Academic Article Cutting edge: antigen-independent CD8 T cell proliferation.
Academic Article A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo.
Academic Article Risk factors and attributable mortality of late aspergillosis after T-cell depleted hematopoietic stem cell transplantation.
Academic Article Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors.
Academic Article Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers.
Academic Article Monocyte-mediated defense against microbial pathogens.
Academic Article Coordinating innate immune cells to optimize microbial killing.
Academic Article Dynamic imaging of the effector immune response to listeria infection in vivo.
Academic Article Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection.
Academic Article The Listeria monocytogenes-secreted p60 protein is an N-end rule substrate in the cytosol of infected cells. Implications for major histocompatibility complex class I antigen processing of bacterial proteins.
Academic Article Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation.
Academic Article Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins.
Academic Article Feedback regulation of pathogen-specific T cell priming.
Academic Article Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes.
Academic Article Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Academic Article Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display.
Academic Article Robust recall and long-term memory T-cell responses induced by prime-boost regimens with heterologous live viral vectors expressing human immunodeficiency virus type 1 Gag and Env proteins.
Academic Article Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation.
Academic Article H2-M3-restricted memory T cells: persistence and activation without expansion.
Academic Article Impaired recovery of Epstein-Barr virus (EBV)--specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease.
Academic Article Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT.
Academic Article Lactose drives Enterococcus expansion to promote graft-versus-host disease.
Academic Article Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors.
Academic Article Compositional Flux Within the Intestinal Microbiota and Risk for Bloodstream Infection With Gram-negative Bacteria.
Academic Article Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation.
Academic Article The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD.
Academic Article Functional and Genomic Variation between Human-Derived Isolates of Lachnospiraceae Reveals Inter- and Intra-Species Diversity.
Academic Article Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study.
Academic Article Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation.
Academic Article TAM mediates adaptation of carbapenem-resistant Klebsiella pneumoniae to antimicrobial stress during host colonization and infection.
Academic Article Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients.
Academic Article Author Correction: Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients.
Academic Article Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation.
Academic Article Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy.
Academic Article A compilation of fecal microbiome shotgun metagenomics from hematopoietic cell transplantation patients.
Academic Article Author Correction: Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy.
Grant Characterization of Aspergillus fumigatus specific CD4 T cell responses.
Grant CC-chemokines in Listeria infection.
Grant Innate Immune Responses to Microbial Flora
Grant H2-M3 RESTRICTED T CELL RESPONSES
Grant CD4 T Cell Responses to M. Tuberculosis Infection
Grant Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant Pathogens
Grant CYTOTOXIC T LYMPHOCYTE RESPONSE TO BACTERIAL INFECTION
Grant Inflammation and T cell immunity to Listeria
Academic Article Assembling symbiotic bacterial species into live therapeutic consortia that reconstitute microbiome functions.
Academic Article High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients.
Academic Article The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia.
Academic Article Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile.
Academic Article Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection.
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