"Killer Cells, Natural" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
| Descriptor ID |
D007694
|
| MeSH Number(s) |
A11.118.637.555.567.537 A15.145.229.637.555.567.537 A15.382.490.555.567.537
|
| Concept/Terms |
Killer Cells, Natural- Killer Cells, Natural
- NK Cells
- Cell, NK
- Cells, NK
- NK Cell
- Natural Killer Cells
- Cell, Natural Killer
- Cells, Natural Killer
- Killer Cell, Natural
- Natural Killer Cell
|
Below are MeSH descriptors whose meaning is more general than "Killer Cells, Natural".
Below are MeSH descriptors whose meaning is more specific than "Killer Cells, Natural".
This graph shows the total number of publications written about "Killer Cells, Natural" by people in this website by year, and whether "Killer Cells, Natural" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1997 | 1 | 2 | 3 |
| 1998 | 1 | 4 | 5 |
| 1999 | 3 | 2 | 5 |
| 2000 | 4 | 2 | 6 |
| 2001 | 0 | 8 | 8 |
| 2002 | 7 | 5 | 12 |
| 2003 | 7 | 3 | 10 |
| 2004 | 6 | 6 | 12 |
| 2005 | 5 | 1 | 6 |
| 2006 | 5 | 5 | 10 |
| 2007 | 8 | 3 | 11 |
| 2008 | 8 | 5 | 13 |
| 2009 | 5 | 4 | 9 |
| 2010 | 3 | 3 | 6 |
| 2011 | 1 | 1 | 2 |
| 2012 | 4 | 2 | 6 |
| 2013 | 3 | 4 | 7 |
| 2014 | 3 | 6 | 9 |
| 2015 | 5 | 5 | 10 |
| 2016 | 3 | 0 | 3 |
| 2017 | 3 | 5 | 8 |
| 2018 | 2 | 1 | 3 |
| 2019 | 4 | 5 | 9 |
| 2020 | 6 | 2 | 8 |
| 2021 | 11 | 2 | 13 |
| 2022 | 2 | 3 | 5 |
| 2023 | 0 | 1 | 1 |
| 2024 | 4 | 3 | 7 |
| 2025 | 4 | 2 | 6 |
| 2026 | 2 | 0 | 2 |
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Below are the most recent publications written about "Killer Cells, Natural" by people in Profiles.
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Integrated Single-Cell Profiling Reveals Dichotomous NK Cell Populations Associated with Immunosuppression in Solid Tumors. Cancer Immunol Res. 2026 Jun 02; 14(6):1008-1021.
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The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors. Immunity. 2026 Mar 10; 59(3):717-733.e10.
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An Fc-Engineered Glycomodified Antibody Supports Proinflammatory Activation of Immune Effector Cells and Restricts Progression of Breast Cancer. Cancer Res. 2025 11 14; 85(22):4521-4540.
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Transcriptional control of natural killer cell antitumor activity. Trends Immunol. 2025 12; 46(12):779-790.
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Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates. Nat Biomed Eng. 2025 Oct; 9(10):1719-1739.
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TP53 mutations and TET2 deficiency cooperate to drive leukemogenesis and establish an immunosuppressive environment. J Clin Invest. 2025 May 15; 135(10).
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Chronic inflammation deters natural killer cell fitness and cytotoxicity in myeloid leukemia. Blood Adv. 2025 Feb 25; 9(4):759-773.
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Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial. Lancet. 2025 01 11; 405(10473):127-136.
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NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1-PD-L1. Sci Immunol. 2024 12 20; 9(102):eadl2967.
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Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity. Elife. 2024 Dec 10; 13.