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Mutlu, Gokhan M.
One or more keywords matched the following properties of Mutlu, Gokhan M.
PropertyValue
keywords Acute Lung Injury
overview Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).
One or more keywords matched the following items that are connected to Mutlu, Gokhan M.
Item TypeName
Concept Lung Diseases
Concept Lung Neoplasms
Concept Lung
Concept Extravascular Lung Water
Concept Lung Diseases, Interstitial
Concept Ventilator-Induced Lung Injury
Concept Lung Injury
Academic Article Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.
Academic Article beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats.
Academic Article Lung-specific loss of the laminin a3 subunit confers resistance to mechanical injury.
Academic Article The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death.
Academic Article Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury.
Academic Article Leptin resistance protects mice from hyperoxia-induced acute lung injury.
Academic Article Mechanisms of pulmonary edema clearance.
Academic Article Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.
Academic Article Pulmonary adverse events of anti-tumor necrosis factor-alpha antibody therapy.
Academic Article Proapoptotic Bid is required for pulmonary fibrosis.
Academic Article Incidence and outcomes of acute lung injury.
Academic Article Acute lung injury does not impair adenoviral-mediated gene transfer to the alveolar epithelium.
Academic Article Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer.
Academic Article Complications of mechanical ventilation.
Academic Article Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-d.
Academic Article The effect of rosuvastatin in a murine model of influenza A infection.
Academic Article Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung.
Academic Article Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms.
Academic Article Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.
Academic Article Comparison of surfactant and perfluorochemical liquid enhanced adenovirus-mediated gene transfer in normal rat lung.
Academic Article Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
Academic Article Nuclear ß-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.
Academic Article Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-?.
Academic Article Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.
Academic Article Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.
Academic Article Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis.
Academic Article Reply: ß2-agonists and acute respiratory distress syndrome.
Academic Article Sequestration of mitochondrial iron by silica particle initiates a biological effect.
Academic Article Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan.
Academic Article Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor.
Academic Article Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis.
Academic Article ß2-agonists and acute respiratory distress syndrome.
Academic Article Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung.
Academic Article Balancing the risks and benefits of oxygen therapy in critically III adults.
Academic Article Toll-like receptor 4 signaling augments transforming growth factor-ß responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.
Academic Article Update in environmental and occupational medicine 2010.
Academic Article Update in environmental and occupational medicine 2009.
Academic Article Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Academic Article Stretch-induced activation of AMP kinase in the lung requires dystroglycan.
Academic Article Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation.
Academic Article Effects of body temperature on ventilator-induced lung injury.
Academic Article Potential genetic therapies for acute lung injury.
Academic Article Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.
Academic Article Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.
Academic Article Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus.
Academic Article Regulation of myofibroblast differentiation by cardiac glycosides.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production.
Academic Article Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.
Academic Article Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.
Academic Article Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.
Academic Article Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.
Academic Article Regulation of allergic lung inflammation by endothelial cell transglutaminase 2.
Academic Article Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Academic Article Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury.
Academic Article African-American race and mortality in interstitial lung disease: a multicentre propensity-matched analysis.
Academic Article Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.
Academic Article Role of Cellular Metabolism in Pulmonary Diseases.
Academic Article P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation.
Academic Article Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.
Academic Article Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Academic Article Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Academic Article TGF-ß Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
Academic Article SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy.
Academic Article SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy.
Grant Role of alveolar macrophages in particulate matter-induced cardiopulmonary disease
Academic Article Update in Critical Care 2020.
Academic Article The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging.
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  • Lung