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Mutlu, Gokhan M.
One or more keywords matched the following properties of Mutlu, Gokhan M.
PropertyValue
keywords Mitochondria
overview Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).
One or more keywords matched the following items that are connected to Mutlu, Gokhan M.
Item TypeName
Academic Article Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.
Academic Article Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.
Academic Article Mitochondrial reactive oxygen species regulate transforming growth factor-ß signaling.
Academic Article Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice.
Academic Article p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis.
Academic Article Sequestration of mitochondrial iron by silica particle initiates a biological effect.
Academic Article Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Academic Article Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
Academic Article Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect.
Academic Article Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.
Academic Article Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes.
Academic Article TGF-ß Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
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  • Mitochondria