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Heparan Sulfate Proteoglycans
Chondroitin Sulfate Proteoglycans
Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors.
Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.
Agarose/polyacrylamide minislab gel electrophoresis of intact cartilage proteoglycans and their proteolytic degradation products.
Detection of functional cell surface perforin by flow cytometry.
Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.
Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.
Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
Molecular Mechanism of Granule-mediated Apoptosis