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Ober, Carole
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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Food Hypersensitivity
Concept Hypersensitivity
Concept Respiratory Hypersensitivity
Concept Hypersensitivity, Immediate
Concept National Institute of Allergy and Infectious Diseases (U.S.)
Academic Article Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Academic Article Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.
Academic Article Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.
Academic Article Effects of dog ownership and genotype on immune development and atopy in infancy.
Academic Article Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
Academic Article Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Academic Article Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Academic Article The genetics of asthma and allergic disease: a 21st century perspective.
Academic Article IFNG genotype and sex interact to influence the risk of childhood asthma.
Academic Article Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects.
Academic Article Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
Academic Article Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy.
Academic Article Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
Academic Article Rising prevalence of asthma is sex-specific in a US farming population.
Academic Article Association studies for asthma and atopic diseases: a comprehensive review of the literature.
Academic Article Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Academic Article Maternal microchimerism protects against the development of asthma.
Academic Article A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Academic Article Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Academic Article Genome-wide association study of lung function phenotypes in a founder population.
Academic Article Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Award or Honor Receipt John E. Salvaggio Memorial Lectureship
Award or Honor Receipt Charles Reed Lectureship
Grant Prenatal Origins of Asthma
Academic Article A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.
Academic Article Immune development and environment: lessons from Amish and Hutterite children.
Academic Article Associations between fungal and bacterial microbiota of airways and asthma endotypes.
Academic Article T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.
Academic Article Advances in asthma and allergic disease genetics: Is bigger always better?
Academic Article Association of HLA-DRB1*09:01 with tIgE levels among African-ancestry individuals with asthma.
Academic Article Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.
Academic Article Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.
Academic Article Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk.
Academic Article Genome-wide association study identifies TNFSF15 associated with childhood asthma.
Academic Article Multiethnic genome-wide and HLA association study of total serum IgE level.
Academic Article Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.
Academic Article Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.
Academic Article A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
Academic Article Asthma-protective agents in dust from traditional farm environments.
Academic Article Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.
Academic Article Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop.
Academic Article Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
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