| Item Type | Name |
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Concept
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Blood Glucose
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Concept
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Glucose Tolerance Test
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Concept
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Glucose Clamp Technique
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Concept
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Glucose Intolerance
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Concept
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Glucose
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Concept
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Glucose Transporter Type 4
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Academic Article
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Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
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Academic Article
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The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
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Academic Article
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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
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Academic Article
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Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
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Academic Article
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The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
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Academic Article
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
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Academic Article
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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
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Academic Article
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Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
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Academic Article
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
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Academic Article
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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
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Academic Article
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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
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Academic Article
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Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.
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Academic Article
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Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
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Academic Article
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
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Academic Article
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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
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Academic Article
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A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
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Academic Article
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Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
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Academic Article
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
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Academic Article
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A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
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Academic Article
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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
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Academic Article
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
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Academic Article
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Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
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Academic Article
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
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Academic Article
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Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
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Academic Article
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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
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Academic Article
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
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Academic Article
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The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
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Academic Article
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
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Academic Article
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
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Academic Article
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
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Academic Article
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
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Academic Article
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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
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Academic Article
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Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets.
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Academic Article
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
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Academic Article
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2-5A-dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2-5A core) in mouse pancreatic islets.
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Academic Article
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Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets.
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Academic Article
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
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Academic Article
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Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans.
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Academic Article
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
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Academic Article
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Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus.
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Academic Article
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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
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Academic Article
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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
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Academic Article
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Molecular insights into insulin action and secretion.
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Academic Article
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
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Academic Article
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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
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Academic Article
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
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Academic Article
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Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.
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Academic Article
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Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
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Academic Article
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The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
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Academic Article
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
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Academic Article
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Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.
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Academic Article
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Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
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Academic Article
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Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
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Academic Article
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Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets.
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Academic Article
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Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
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Academic Article
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Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
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Academic Article
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IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
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Academic Article
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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
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Academic Article
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Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
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Academic Article
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Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
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Academic Article
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SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
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Academic Article
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The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.
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Academic Article
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Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.
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Academic Article
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Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
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Academic Article
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
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Academic Article
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The dynamic plasticity of insulin production in ß-cells.
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Academic Article
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Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
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Academic Article
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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production.
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Academic Article
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Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
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Academic Article
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Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
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Academic Article
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
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Academic Article
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A fluorescent timer reporter enables sorting of insulin secretory granules by age.
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Academic Article
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Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.
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Academic Article
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Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
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Grant
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Mitogenic Signal Transduction in Pancreatic Beta-Cells
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Grant
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Central Control of Pancreatic Islet Function
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Academic Article
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Hepatic Glucagon Action - Beyond Glucose Mobilization.
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