3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
| Descriptor ID |
D001498
|
| MeSH Number(s) |
D03.383.725.203.600 D03.383.725.547.900
|
| Concept/Terms |
Bay-R-5417- Bay-R-5417
- Bay R 5417
- BayR5417
- Bay R5417
- R5417, Bay
Bay-K-8644- Bay-K-8644
- Bay K 8644
- BayK8644
- Bay-K8644
- Bay K8644
- BK-8644
- BK 8644
- BK8644
|
Below are MeSH descriptors whose meaning is more general than "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester".
Below are MeSH descriptors whose meaning is more specific than "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester".
This graph shows the total number of publications written about "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" by people in this website by year, and whether "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" by people in Profiles.
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Effect of BayK 8644 on [Ca??]i and viability in PC3 human prostate cancer cells. Chin J Physiol. 2013 Dec 31; 56(6):318-25.
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Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus. Pediatr Res. 2008 Feb; 63(2):176-81.
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Continuous and transient vesicle cycling at a ribbon synapse. J Neurosci. 1998 Nov 01; 18(21):8614-24.
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Conotoxin-sensitive and conotoxin-resistant Ca2+ currents in fish retinal ganglion cells. J Neurobiol. 1996 Apr; 29(4):429-44.
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NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity. Am J Physiol. 1996 Jan; 270(1 Pt 1):E133-40.
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Ca2+ current enhancement by alpha 2/delta and beta subunits in Xenopus oocytes: contribution of changes in channel gating and alpha 1 protein level. J Physiol. 1995 Nov 15; 489 ( Pt 1):55-62.
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Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion. Diabetes. 1993 Jul; 42(7):948-55.
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Tumor necrosis factor modulates Ca2+ currents in cultured sympathetic neurons. J Neurosci. 1992 Jul; 12(7):2665-71.
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Dihydropyridine-sensitive L-type Ca2+ channels in human foreskin fibroblast cells. Characterization of activation with the growth factor Lys-bradykinin. J Biol Chem. 1992 May 25; 267(15):10524-30.
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Bradykinin stimulates Ca2+ entry via nitrendipine-sensitive Ca2+ channels in cultured human fibroblasts. Agents Actions Suppl. 1992; 38 ( Pt 2):1-8.