 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
| Descriptor ID |
D001498
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| MeSH Number(s) |
D03.383.725.203.600 D03.383.725.547.900
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| Concept/Terms |
Bay-R-5417- Bay-R-5417
- Bay R 5417
- BayR5417
- Bay R5417
- R5417, Bay
Bay-K-8644- Bay-K-8644
- Bay K 8644
- BayK8644
- BK-8644
- BK 8644
- BK8644
- Bay-K8644
- Bay K8644
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Below are MeSH descriptors whose meaning is more general than "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester".
Below are MeSH descriptors whose meaning is more specific than "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester".
This graph shows the total number of publications written about "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" by people in this website by year, and whether "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 0 | 1 | 1 | | 1992 | 0 | 3 | 3 | | 1993 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" by people in Profiles.
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Lai ZR, Chou CT, Liu SI, Liang WZ, Huang JK, Jan CR. Effect of BayK 8644 on [Ca²?]i and viability in PC3 human prostate cancer cells. Chin J Physiol. 2013 Dec 31; 56(6):318-25.
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Thébaud B, Wu XC, Kajimoto H, Bonnet S, Hashimoto K, Michelakis ED, Archer SL. Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus. Pediatr Res. 2008 Feb; 63(2):176-81.
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Rouze NC, Schwartz EA. Continuous and transient vesicle cycling at a ribbon synapse. J Neurosci. 1998 Nov 01; 18(21):8614-24.
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Bindokas VP, Ishida AT. Conotoxin-sensitive and conotoxin-resistant Ca2+ currents in fish retinal ganglion cells. J Neurobiol. 1996 Apr; 29(4):429-44.
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Roe MW, Worley JF, Tokuyama Y, Philipson LH, Sturis J, Tang J, Dukes ID, Bell GI, Polonsky KS. NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity. Am J Physiol. 1996 Jan; 270(1 Pt 1):E133-40.
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Shistik E, Ivanina T, Puri T, Hosey M, Dascal N. Ca2+ current enhancement by alpha 2/delta and beta subunits in Xenopus oocytes: contribution of changes in channel gating and alpha 1 protein level. J Physiol. 1995 Nov 15; 489 ( Pt 1):55-62.
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Iwashima Y, Pugh W, Depaoli AM, Takeda J, Seino S, Bell GI, Polonsky KS. Expression of calcium channel mRNAs in rat pancreatic islets and downregulation after glucose infusion. Diabetes. 1993 Jul; 42(7):948-55.
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Soliven B, Albert J. Tumor necrosis factor modulates Ca2+ currents in cultured sympathetic neurons. J Neurosci. 1992 Jul; 12(7):2665-71.
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Baumgarten LB, Toscas K, Villereal ML. Dihydropyridine-sensitive L-type Ca2+ channels in human foreskin fibroblast cells. Characterization of activation with the growth factor Lys-bradykinin. J Biol Chem. 1992 May 25; 267(15):10524-30.
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Baumgarten L, Villereal M. Bradykinin stimulates Ca2+ entry via nitrendipine-sensitive Ca2+ channels in cultured human fibroblasts. Agents Actions Suppl. 1992; 38 ( Pt 2):1-8.
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