 Adrenoleukodystrophy
"Adrenoleukodystrophy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).
| Descriptor ID |
D000326
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| MeSH Number(s) |
C10.228.140.163.100.362.250 C10.228.140.163.100.680.100 C10.228.140.695.625.250 C10.228.518.625.250 C10.314.400.250 C10.597.606.643.455.124 C16.320.322.500.124 C16.320.400.525.124 C16.320.565.189.362.250 C16.320.565.189.680.100 C16.320.565.663.112 C18.452.132.100.362.250 C18.452.132.100.680.100 C18.452.648.189.362.250 C18.452.648.189.680.100 C18.452.648.663.112 C19.053.500.270
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| Concept/Terms |
Adrenoleukodystrophy- Adrenoleukodystrophy
- Adrenoleukodystrophies
- Schilder-Addison Complex
- Schilder Addison Complex
- X-Linked Adrenoleukodystrophy
- Adrenoleukodystrophies, X-Linked
- Adrenoleukodystrophy, X-Linked
- X Linked Adrenoleukodystrophy
- X-Linked Adrenoleukodystrophies
- ALD (Adrenoleukodystrophy)
- ALDs (Adrenoleukodystrophy)
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Below are MeSH descriptors whose meaning is more general than "Adrenoleukodystrophy".
- Diseases [C]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Brain Diseases, Metabolic [C10.228.140.163]
- Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
- Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.163.100.362]
- Adrenoleukodystrophy [C10.228.140.163.100.362.250]
- Peroxisomal Disorders [C10.228.140.163.100.680]
- Adrenoleukodystrophy [C10.228.140.163.100.680.100]
- Leukoencephalopathies [C10.228.140.695]
- Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.695.625]
- Adrenoleukodystrophy [C10.228.140.695.625.250]
- Leukoencephalopathies [C10.228.518]
- Hereditary Central Nervous System Demyelinating Diseases [C10.228.518.625]
- Adrenoleukodystrophy [C10.228.518.625.250]
- Demyelinating Diseases [C10.314]
- Hereditary Central Nervous System Demyelinating Diseases [C10.314.400]
- Adrenoleukodystrophy [C10.314.400.250]
- Neurologic Manifestations [C10.597]
- Neurobehavioral Manifestations [C10.597.606]
- Intellectual Disability [C10.597.606.643]
- Mental Retardation, X-Linked [C10.597.606.643.455]
- Adrenoleukodystrophy [C10.597.606.643.455.124]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
- Genetic Diseases, X-Linked [C16.320.322]
- Mental Retardation, X-Linked [C16.320.322.500]
- Adrenoleukodystrophy [C16.320.322.500.124]
- Heredodegenerative Disorders, Nervous System [C16.320.400]
- Mental Retardation, X-Linked [C16.320.400.525]
- Adrenoleukodystrophy [C16.320.400.525.124]
- Metabolism, Inborn Errors [C16.320.565]
- Brain Diseases, Metabolic, Inborn [C16.320.565.189]
- Hereditary Central Nervous System Demyelinating Diseases [C16.320.565.189.362]
- Adrenoleukodystrophy [C16.320.565.189.362.250]
- Peroxisomal Disorders [C16.320.565.189.680]
- Adrenoleukodystrophy [C16.320.565.189.680.100]
- Peroxisomal Disorders [C16.320.565.663]
- Adrenoleukodystrophy [C16.320.565.663.112]
- Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
- Brain Diseases, Metabolic [C18.452.132]
- Brain Diseases, Metabolic, Inborn [C18.452.132.100]
- Hereditary Central Nervous System Demyelinating Diseases [C18.452.132.100.362]
- Adrenoleukodystrophy [C18.452.132.100.362.250]
- Peroxisomal Disorders [C18.452.132.100.680]
- Adrenoleukodystrophy [C18.452.132.100.680.100]
- Metabolism, Inborn Errors [C18.452.648]
- Brain Diseases, Metabolic, Inborn [C18.452.648.189]
- Hereditary Central Nervous System Demyelinating Diseases [C18.452.648.189.362]
- Adrenoleukodystrophy [C18.452.648.189.362.250]
- Peroxisomal Disorders [C18.452.648.189.680]
- Adrenoleukodystrophy [C18.452.648.189.680.100]
- Peroxisomal Disorders [C18.452.648.663]
- Adrenoleukodystrophy [C18.452.648.663.112]
- Endocrine System Diseases [C19]
- Adrenal Gland Diseases [C19.053]
- Adrenal Insufficiency [C19.053.500]
- Adrenoleukodystrophy [C19.053.500.270]
Below are MeSH descriptors whose meaning is more specific than "Adrenoleukodystrophy".
This graph shows the total number of publications written about "Adrenoleukodystrophy" by people in this website by year, and whether "Adrenoleukodystrophy" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 1 | 0 | 1 | | 1987 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Adrenoleukodystrophy" by people in Profiles.
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Hong-Magno ET, Muraki AS, Huttenlocher PR. Atypical CT scans in adrenoleukodystrophy. J Comput Assist Tomogr. 1987 Mar-Apr; 11(2):333-6.
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Kelley RI, Datta NS, Dobyns WB, Hajra AK, Moser AB, Noetzel MJ, Zackai EH, Moser HW. Neonatal adrenoleukodystrophy: new cases, biochemical studies, and differentiation from Zellweger and related peroxisomal polydystrophy syndromes. Am J Med Genet. 1986 Apr; 23(4):869-901.
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