A rare central nervous system demyelinating condition affecting children and young adults. Pathologic findings include a large, sharply defined, asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy. Concentric sclerosis of Balo is differentiated from diffuse cerebral sclerosis of Schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. (From Adams et al., Principles of Neurology, 6th ed, p914; Dev Neurosci 1991;13(4-5):267-73)

Descriptor ID	D002549
MeSH Number(s)	C10.114.375.112 C10.228.140.400 C10.228.140.695.562.112 C10.228.518.562.112 C10.314.350.112 C20.111.258.250.175
Concept/Terms	Diffuse Cerebral Sclerosis of Schilder Diffuse Cerebral Sclerosis of Schilder Myelinoclastic Diffuse Sclerosis Diffuse Scleroses, Myelinoclastic Diffuse Sclerosis, Myelinoclastic Myelinoclastic Diffuse Scleroses Scleroses, Myelinoclastic Diffuse Sclerosis, Myelinoclastic Diffuse Poliodystrophia Cerebri Schilder Disease Disease, Schilder Encephalitis Periaxialis Concentrica Cerebral Sclerosis, Diffuse Diffuse Cerebral Scleroses Diffuse Cerebral Sclerosis Sclerosis, Diffuse Cerebral Encephalitis Periaxialis Encephalitis Periaxialis Diffusa Schilder's Disease Disease, Schilder's Schilders Disease Balo Concentric Sclerosis Balo Concentric Sclerosis Concentric Sclerosis, Balo Balo's Concentric Sclerosis Concentric Sclerosis, Balo's Scleroses, Balo's Concentric Alpers Syndrome Alpers Syndrome Syndrome, Alpers Progressive Sclerosing Poliodystrophy Progressive Sclerosing Poliodystrophies Alpers-Huttenlocher Syndrome Alpers Huttenlocher Syndrome Syndrome, Alpers-Huttenlocher Alpers Progressive Infantile Poliodystrophy Alpers' Disease Alper Disease Alper's Disease Disease, Alpers' Alpers' Syndrome Alper Syndrome Alper's Syndrome Progressive Neuronal Degeneration of Childhood with Liver Disease Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis

Below are MeSH descriptors whose meaning is more general than "Diffuse Cerebral Sclerosis of Schilder".

Below are MeSH descriptors whose meaning is related to "Diffuse Cerebral Sclerosis of Schilder".

Below are MeSH descriptors whose meaning is more specific than "Diffuse Cerebral Sclerosis of Schilder".