"Sterol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.
| Descriptor ID |
D002785
|
| MeSH Number(s) |
D08.811.913.050.799
|
| Concept/Terms |
Sterol O-Acyltransferase- Sterol O-Acyltransferase
- O-Acyltransferase, Sterol
- Sterol O Acyltransferase
- Cholesterol Esterifying Enzyme
- Enzyme, Cholesterol Esterifying
- Esterifying Enzyme, Cholesterol
- Acyl-CoA-Cholesterol Acyltransferase
- Acyl CoA Cholesterol Acyltransferase
- Acyltransferase, Acyl-CoA-Cholesterol
- Cholesterol Acyltransferase
- Acyltransferase, Cholesterol
|
Below are MeSH descriptors whose meaning is more general than "Sterol O-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Sterol O-Acyltransferase".
This graph shows the total number of publications written about "Sterol O-Acyltransferase" by people in this website by year, and whether "Sterol O-Acyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1994 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
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Below are the most recent publications written about "Sterol O-Acyltransferase" by people in Profiles.
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Therapies targeting exogenous cholesterol uptake: new insights and controversies. Curr Atheroscler Rep. 2011 Feb; 13(1):95-100.
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Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal. J Clin Endocrinol Metab. 2011 Apr; 96(4):E663-8.
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ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial. JAMA. 2009 Mar 18; 301(11):1131-9.
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Effect of ACAT inhibition on the progression of coronary atherosclerosis. N Engl J Med. 2006 Mar 23; 354(12):1253-63.
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Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE-/- mice. J Lipid Res. 2005 Oct; 46(10):2091-101.
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Expression of scavenger receptor BI facilitates sterol movement between the plasma membrane and the endoplasmic reticulum in macrophages. Biochemistry. 2003 Apr 08; 42(13):3949-55.
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The in-vitro influence of serum amyloid A isoforms on enzymes that regulate the balance between esterified and un-esterified cholesterol. Amyloid. 2001 Sep; 8(3):169-81.
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Efficacy and short-term safety of a new ACAT inhibitor, avasimibe, on lipids, lipoproteins, and apolipoproteins, in patients with combined hyperlipidemia. Atherosclerosis. 2001 Jul; 157(1):137-44.
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Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J Biol Chem. 2000 Sep 08; 275(36):28083-92.
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Quantitation of the pool of cholesterol associated with acyl-CoA:cholesterol acyltransferase in human fibroblasts. J Biol Chem. 1997 May 16; 272(20):13103-8.