Phosphatidylcholine-Sterol O-Acyltransferase
"Phosphatidylcholine-Sterol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.
| Descriptor ID |
D007862
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| MeSH Number(s) |
D08.811.913.050.625
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| Concept/Terms |
Phosphatidylcholine-Sterol O-Acyltransferase- Phosphatidylcholine-Sterol O-Acyltransferase
- O-Acyltransferase, Phosphatidylcholine-Sterol
- Phosphatidylcholine Sterol O Acyltransferase
- Lecithin Cholesterol Acyltransferase
- Acyltransferase, Lecithin Cholesterol
- Cholesterol Acyltransferase, Lecithin
- Lecithin Acyltransferase
- Acyltransferase, Lecithin
- Cholesterol Ester Lysolecithin Acyltransferase
- Phosophatidylcholine-Sterol Acyltransferase
- Acyltransferase, Phosophatidylcholine-Sterol
- Phosophatidylcholine Sterol Acyltransferase
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylcholine-Sterol O-Acyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylcholine-Sterol O-Acyltransferase".
This graph shows the total number of publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in this website by year, and whether "Phosphatidylcholine-Sterol O-Acyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in Profiles.
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Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein. J Lipid Res. 2012 May; 53(5):951-963.
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Evidence for altered positional specificity of LCAT in vivo: studies with docosahexaenoic acid feeding in humans. J Lipid Res. 2004 Dec; 45(12):2245-51.
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In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice. Biochemistry. 2001 Nov 13; 40(45):13670-80.
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Effects of probucol on plasma lipids, lipoproteins and parameters of high density lipoprotein metabolism. Horm Metab Res. 1992 Jun; 24(6):289-96.
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Plasma lipids and acyltransferase activities in experimental nephrotic syndrome. Kidney Int. 1989 Aug; 36(2):240-8.
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Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: effects of incubation with lecithin: cholesterol acyltransferase in vitro. Scand J Clin Lab Invest Suppl. 1975; 142:31-55.