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Narayanan Kasthuri

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentNeurobiology
AddressChicago IL 60637
Email
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    U01NS136401     (KASTHURI, NARAYANAN)Aug 1, 2024 - Jul 31, 2027
    NIH
    BRAIN CONNECTS: Photoemission Electron Microscopy for Connectomics
    Role: Principal Investigator
    R01NS113922     (SHERMAN, S. MURRAY)Aug 1, 2020 - May 31, 2025
    NIH
    Connectome of circuits within and between thalamus and cortex
    Role: Co-Principal Investigator
    R01MH110932     (CAI, DAWEN)Jul 1, 2016 - Apr 30, 2021
    NIH
    An Accessible Optical Toolbox for Saturated Nanoscale Analysis of Neural Architecture
    Role: Co-Principal Investigator
    U01MH109100     (JACOBSEN, CHRIS JOHNSON)Sep 23, 2015 - Jun 30, 2018
    NIH
    Sub-micrometer x-ray tomography for neuroanatomy
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sampathkumar V, Koster KP, Carroll BJ, Sherman SM, Kasthuri N. Synaptic integration of somatosensory and motor cortical inputs onto spiny projection neurons of mice caudoputamen. Eur J Neurosci. 2024 Oct; 60(8):6107-6122. PMID: 39315531; PMCID: PMC11483202.
      Citations:    Translation:AnimalsCells
    2. Li R, Wildenberg G, Boergens K, Yang Y, Weber K, Rieger J, Arcidiacono A, Klie R, Kasthuri N, King SB, Li R, Wildenberg G, Boergens K, Yang Y, Weber K, Rieger J, Arcidiacono A, Klie R, Kasthuri N, King SB. OsO2 as the Contrast-Generating Chemical Species of Osmium-Stained Biological Tissues in Electron Microscopy. Chembiochem. 2024 Oct 16; 25(20):e202400311. PMID: 39037826.
      Citations:    Fields:    Translation:Animals
    3. Paukner D, Wildenberg GA, Badalamente GS, Littlewood PB, Kronforst MR, Palmer SE, Kasthuri N. Synchrotron-source micro-x-ray computed tomography for examining butterfly eyes. Ecol Evol. 2024 Apr; 14(4):e11137. PMID: 38571794; PMCID: PMC10985371.
      Citations: 2     
    4. Boergens KM, Li R, Lambert L, Moradi A, Stam G, Tromp R, van der Molen SJ, King SB, Kasthuri N, Wildenberg G. Photoemission electron microscopy for connectomics. bioRxiv. 2024 Apr 01. PMID: 37771915; PMCID: PMC10525389.
      Citations:    
    5. IMAXT Grand Challenge Consortium, Shin TW, Wang H, Zhang C, An B, Lu Y, Zhang E, Lu X, Karagiannis ED, Kang JS, Emenari A, Symvoulidis P, Asano S, Lin L, Costa EK, Marblestone AH, Kasthuri N, Tsai LH, Boyden ES. Dense, Continuous Membrane Labeling and Expansion Microscopy Visualization of Ultrastructure in Tissues. bioRxiv. 2024 Mar 08. PMID: 38496681; PMCID: PMC10942445.
      Citations:    
    6. Wildenberg G, Li H, Sampathkumar V, Sorokina A, Kasthuri N. Isochronic development of cortical synapses in primates and mice. Nat Commun. 2023 Dec 04; 14(1):8018. PMID: 38049416; PMCID: PMC10695974.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Wildenberg G, Li H, Kasthuri N. The Development of Synapses in Mouse and Macaque Primary Sensory Cortices. bioRxiv. 2023 Feb 15. PMID: 36824798; PMCID: PMC9949058.
      Citations:    
    8. Carroll BJ, Sampathkumar V, Kasthuri N, Sherman SM. Layer 5 of cortex innervates the thalamic reticular nucleus in mice. Proc Natl Acad Sci U S A. 2022 09 20; 119(38):e2205209119. PMID: 36095204; PMCID: PMC9499584.
      Citations: 8     Fields:    Translation:AnimalsCells
    9. Hamnett R, Dershowitz LB, Sampathkumar V, Wang Z, Gomez-Frittelli J, De Andrade V, Kasthuri N, Druckmann S, Kaltschmidt JA. Regional cytoarchitecture of the adult and developing mouse enteric nervous system. Curr Biol. 2022 10 24; 32(20):4483-4492.e5. PMID: 36070775; PMCID: PMC9613618.
      Citations: 12     Fields:    Translation:AnimalsCells
    10. Poli JA, Howard C, Garcia AJ, Remboski D, Littlewood PB, Kress JP, Kasthuri N, Comai A, Soni K, Kennedy P, Ogger J, DiBlasi RM. Performance Characteristics of a Novel 3D-Printed Bubble Intermittent Mandatory Ventilator (B-IMV) for Adult Pulmonary Support. Bioengineering (Basel). 2022 Apr 02; 9(4). PMID: 35447711; PMCID: PMC9027535.
      Citations: 1     
    11. Wildenberg GA, Rosen MR, Lundell J, Paukner D, Freedman DJ, Kasthuri N. Primate neuronal connections are sparse in cortex as compared to mouse. Cell Rep. 2021 09 14; 36(11):109709. PMID: 34525373.
      Citations: 14     Fields:    Translation:AnimalsCells
    12. Trinkle S, Foxley S, Wildenberg G, Kasthuri N, La Rivière P. The role of spatial embedding in mouse brain networks constructed from diffusion tractography and tracer injections. Neuroimage. 2021 12 01; 244:118576. PMID: 34520833; PMCID: PMC8611903.
      Citations: 4     Fields:    Translation:Animals
    13. Sampathkumar V, Miller-Hansen A, Sherman SM, Kasthuri N. Integration of signals from different cortical areas in higher order thalamic neurons. Proc Natl Acad Sci U S A. 2021 Jul 27; 118(30). PMID: 34282018; PMCID: PMC8325356.
      Citations: 15     Fields:    Translation:AnimalsCells
    14. Foxley S, Sampathkumar V, De Andrade V, Trinkle S, Sorokina A, Norwood K, La Riviere P, Kasthuri N. Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution. Neuroimage. 2021 09; 238:118250. PMID: 34116154; PMCID: PMC8388011.
      Citations: 10     Fields:    Translation:Animals
    15. Ofer N, Berger DR, Kasthuri N, Lichtman JW, Yuste R. Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies. Dev Neurobiol. 2021 07; 81(5):746-757. PMID: 33977655; PMCID: PMC8852350.
      Citations: 19     Fields:    Translation:AnimalsCells
    16. Trinkle S, Foxley S, Kasthuri N, La Rivière P. Synchrotron X-ray micro-CT as a validation dataset for diffusion MRI in whole mouse brain. Magn Reson Med. 2021 08; 86(2):1067-1076. PMID: 33768633; PMCID: PMC8076078.
      Citations: 3     Fields:    Translation:Animals
    17. Sampathkumar V, Miller-Hansen A, Murray Sherman S, Kasthuri N. An ultrastructural connectomic analysis of a higher-order thalamocortical circuit in the mouse. Eur J Neurosci. 2021 02; 53(3):750-762. PMID: 33368722.
      Citations: 5     Translation:AnimalsCells
    18. Prasad JA, Balwani AH, Johnson EC, Miano JD, Sampathkumar V, De Andrade V, Fezzaa K, Du M, Vescovi R, Jacobsen C, Kording KP, Gray Roncal W, Kasthuri N, Dyer EL, Gürsoy D. A three-dimensional thalamocortical dataset for characterizing brain heterogeneity. Sci Data. 2020 10 20; 7(1):358. PMID: 33082340; PMCID: PMC7576781.
      Citations: 6     Fields:    Translation:Animals
    19. Abbott LF, Bock DD, Callaway EM, Denk W, Dulac C, Fairhall AL, Fiete I, Harris KM, Helmstaedter M, Jain V, Kasthuri N, LeCun Y, Lichtman JW, Littlewood PB, Luo L, Maunsell JHR, Reid RC, Rosen BR, Rubin GM, Sejnowski TJ, Seung HS, Svoboda K, Tank DW, Tsao D, Van Essen DC. The Mind of a Mouse. Cell. 2020 09 17; 182(6):1372-1376. PMID: 32946777.
      Citations: 77     Fields:    Translation:AnimalsCells
    20. Foxley S, Wildenberg G, Sampathkumar V, Karczmar GS, Brugarolas P, Kasthuri N. Sensitivity to myelin using model-free analysis of the water resonance line-shape in postmortem mouse brain. Magn Reson Med. 2021 02; 85(2):667-677. PMID: 32783262.
      Citations: 1     Fields:    Translation:AnimalsCells
    21. Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43. PMID: 32347164; PMCID: PMC7334106.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    22. De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ, Le Metayer T, Hansen MT, Shim HN, Krause SV, Freedman DJ, Bindokas VP, Kasthuri N, Nicholson DA, Contractor A, Thinakaran G. Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. Cell Rep. 2020 03 10; 30(10):3520-3535.e7. PMID: 32160554; PMCID: PMC7146643.
      Citations: 35     Fields:    Translation:AnimalsCells
    23. Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, Grutzendler J, Kasthuri N, Scheirer WJ, da Costa NM. Publisher Correction: Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes. Sci Rep. 2018 Nov 29; 8(1):17585. PMID: 30498261; PMCID: PMC6265300.
      Citations:    Fields:    
    24. Shahbazi A, Kinnison J, Vescovi R, Du M, Hill R, Joesch M, Takeno M, Zeng H, Grutzendler J, Kasthuri N, Scheirer WJ, da Costa NM. Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes. Sci Rep. 2018 09 24; 8(1):14247. PMID: 30250218; PMCID: PMC6155135.
      Citations: 4     Fields:    Translation:Animals
    25. Yang X, De Andrade V, Scullin W, Dyer EL, Kasthuri N, De Carlo F, Gürsoy D. Low-dose x-ray tomography through a deep convolutional neural network. Sci Rep. 2018 02 07; 8(1):2575. PMID: 29416047; PMCID: PMC5803233.
      Citations: 19     Fields:    Translation:Animals
    26. Dyer EL, Gray Roncal W, Prasad JA, Fernandes HL, De Andrade V, Fezzaa K, Xiao X, Vogelstein JT, Jacobsen C, Kasthuri N, Gürsoy D, Körding KP. Quantifying Mesoscale Neuroanatomy Using X-Ray Microtomography. eNeuro. 2017 Sep-Oct; 4(5). PMID: 29085899; PMCID: PMC5659258.
      Citations: 43     Fields:    Translation:AnimalsCells
    27. Ocola LE, Sampathkumar V, Kasthuri N, Winarski RP. Contrast enhancement of biological nanoporous materials with zinc oxide infiltration for electron and X-ray nanoscale microscopy. Sci Rep. 2017 07 19; 7(1):5879. PMID: 28724918; PMCID: PMC5517423.
      Citations: 1     Fields:    
    28. Bouchard KE, Aimone JB, Chun M, Dean T, Donofrio DD, Frank LM, Kasthuri N, Koch C, Ruebel O, Simon HD, Sommer FT, Denker M, Diesmann M. High-Performance Computing in Neuroscience for Data-Driven Discovery, Integration, and Dissemination. Neuron. 2016 Nov 02; 92(3):628-631. PMID: 27810006.
      Citations: 14     Fields:    Translation:Humans
    29. Ai-Awami AK, Beyer J, Haehn D, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M. NeuroBlocks--Visual Tracking of Segmentation and Proofreading for Large Connectomics Projects. IEEE Trans Vis Comput Graph. 2016 Jan; 22(1):738-46. PMID: 26529725.
      Citations: 12     Fields:    Translation:Humans
    30. Kasthuri N, Hayworth KJ, Berger DR, Schalek RL, Knowles-Barley S, Lee D, Kaynig V, Jones TR, Roberts M, Morgan JL, Tapia JC, Seung HS, Roncal WG, Vogelstein JT, Burns R, Sussman DL, Priebe CE, Pfister H, Lichtman JW, Conchello JA, Vázquez-Reina A. Saturated Reconstruction of a Volume of Neocortex. Cell. 2015 Jul 30; 162(3):648-61. PMID: 26232230.
      Citations: 429     Fields:    Translation:AnimalsCells
    31. Kaynig V, Vazquez-Reina A, Knowles-Barley S, Roberts M, Jones TR, Kasthuri N, Miller E, Lichtman J, Pfister H. Large-scale automatic reconstruction of neuronal processes from electron microscopy images. Med Image Anal. 2015 May; 22(1):77-88. PMID: 25791436; PMCID: PMC4406409.
      Citations: 36     Fields:    Translation:Cells
    32. Al-Awami AK, Beyer J, Strobelt H, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M. NeuroLines: A Subway Map Metaphor for Visualizing Nanoscale Neuronal Connectivity. IEEE Trans Vis Comput Graph. 2014 Dec; 20(12):2369-78. PMID: 26356951.
      Citations: 13     Fields:    Translation:HumansCells
    33. Haehn D, Knowles-Barley S, Roberts M, Beyer J, Kasthuri N, Lichtman JW, Pfister H. Design and Evaluation of Interactive Proofreading Tools for Connectomics. IEEE Trans Vis Comput Graph. 2014 Dec; 20(12):2466-75. PMID: 26356960.
      Citations: 14     Fields:    Translation:HumansAnimals
    34. Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P. Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science. 2014 Apr 18; 344(6181):319-24. PMID: 24744380; PMCID: PMC4122120.
      Citations: 258     Fields:    Translation:AnimalsCells
    35. Beyer J, Al-Awami A, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M. ConnectomeExplorer: query-guided visual analysis of large volumetric neuroscience data. IEEE Trans Vis Comput Graph. 2013 Dec; 19(12):2868-77. PMID: 24051854; PMCID: PMC4296725.
      Citations: 16     Fields:    Translation:Cells
    36. Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM. Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell. 2013 Jul 18; 154(2):285-96. PMID: 23870120; PMCID: PMC3767119.
      Citations: 103     Fields:    Translation:AnimalsCells
    37. Beyer J, Hadwiger M, Al-Awami A, Jeong WK, Kasthuri N, Lichtman JW, Pfister H. Exploring the connectome: petascale volume visualization of microscopy data streams. IEEE Comput Graph Appl. 2013 Jul-Aug; 33(4):50-61. PMID: 24808059; PMCID: PMC4296712.
      Citations: 6     Fields:    Translation:Animals
    38. Burns R, Roncal WG, Kleissas D, Lillaney K, Manavalan P, Perlman E, Berger DR, Bock DD, Chung K, Grosenick L, Kasthuri N, Weiler NC, Deisseroth K, Kazhdan M, Lichtman J, Reid RC, Smith SJ, Szalay AS, Vogelstein JT, Vogelstein RJ. The Open Connectome Project Data Cluster: Scalable Analysis and Vision for High-Throughput Neuroscience. Sci Stat Database Manag. 2013. PMID: 24401992; PMCID: PMC3881956.
      Citations: 23     
    39. Glenn DR, Zhang H, Kasthuri N, Schalek R, Lo PK, Trifonov AS, Park H, Lichtman JW, Walsworth RL. Correlative light and electron microscopy using cathodoluminescence from nanoparticles with distinguishable colours. Sci Rep. 2012; 2:865. PMID: 23155483; PMCID: PMC3498735.
      Citations: 18     Fields:    
    40. Tapia JC, Wylie JD, Kasthuri N, Hayworth KJ, Schalek R, Berger DR, Guatimosim C, Seung HS, Lichtman JW. Pervasive synaptic branch removal in the mammalian neuromuscular system at birth. Neuron. 2012 Jun 07; 74(5):816-29. PMID: 22681687.
      Citations: 72     Fields:    Translation:AnimalsCells
    41. Tapia JC, Kasthuri N, Hayworth KJ, Schalek R, Lichtman JW, Smith SJ, Buchanan J. High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy. Nat Protoc. 2012 Jan 12; 7(2):193-206. PMID: 22240582; PMCID: PMC3701260.
      Citations: 131     Fields:    Translation:AnimalsCells
    42. Fox MA, Tapia JC, Kasthuri N, Lichtman JW. Delayed synapse elimination in mouse levator palpebrae superioris muscle. J Comp Neurol. 2011 Oct 15; 519(15):2907-21. PMID: 21681746; PMCID: PMC3268260.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. Kasthuri N, Lichtman JW. Neurocartography. Neuropsychopharmacology. 2010 Jan; 35(1):342-3. PMID: 20010709; PMCID: PMC2849285.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    44. Kasthuri N, Lichtman JW. The rise of the 'projectome'. Nat Methods. 2007 Apr; 4(4):307-8. PMID: 17396125.
      Citations: 29     Fields:    Translation:HumansAnimals
    45. Kasthuri N, Lichtman JW. Structural dynamics of synapses in living animals. Curr Opin Neurobiol. 2004 Feb; 14(1):105-11. PMID: 15018945.
      Citations: 7     Fields:    Translation:AnimalsCells
    46. Kasthuri N, Lichtman JW. The role of neuronal identity in synaptic competition. Nature. 2003 Jul 24; 424(6947):426-30. PMID: 12879070.
      Citations: 41     Fields:    Translation:AnimalsCells
    47. Grutzendler J, Kasthuri N, Gan WB. Long-term dendritic spine stability in the adult cortex. Nature. 2002 Dec 19-26; 420(6917):812-6. PMID: 12490949.
      Citations: 496     Fields:    Translation:AnimalsCells
    48. Kettunen P, Demas J, Lohmann C, Kasthuri N, Gong Y, Wong RO, Gan WB. Imaging calcium dynamics in the nervous system by means of ballistic delivery of indicators. J Neurosci Methods. 2002 Sep 15; 119(1):37-43. PMID: 12234633.
      Citations: 13     Fields:    Translation:AnimalsCells
    49. Pike FG, Goddard RS, Suckling JM, Ganter P, Kasthuri N, Paulsen O. Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents. J Physiol. 2000 Nov 15; 529 Pt 1:205-13. PMID: 11080262; PMCID: PMC2270176.
      Citations: 167     Fields:    Translation:AnimalsCells
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