 Glutamate-Cysteine Ligase
"Glutamate-Cysteine Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
| Descriptor ID |
D005721
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| MeSH Number(s) |
D08.811.464.259.850.400
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| Concept/Terms |
Glutamate-Cysteine Ligase- Glutamate-Cysteine Ligase
- Glutamate Cysteine Ligase
- Ligase, Glutamate-Cysteine
- gamma-Glutamyl-Cysteine Synthetase
- Synthetase, gamma-Glutamyl-Cysteine
- gamma Glutamyl Cysteine Synthetase
- Glutamylcysteine Synthetase
- Synthetase, Glutamylcysteine
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Below are MeSH descriptors whose meaning is more general than "Glutamate-Cysteine Ligase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate-Cysteine Ligase".
This graph shows the total number of publications written about "Glutamate-Cysteine Ligase" by people in this website by year, and whether "Glutamate-Cysteine Ligase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutamate-Cysteine Ligase" by people in Profiles.
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Villablanca JG, Volchenboum SL, Cho H, Kang MH, Cohn SL, Anderson CP, Marachelian A, Groshen S, Tsao-Wei D, Matthay KK, Maris JM, Hasenauer CE, Czarnecki S, Lai H, Goodarzian F, Shimada H, Reynolds CP. A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma. Pediatr Blood Cancer. 2016 08; 63(8):1349-56.
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Schumacker PT. Reactive oxygen species in cancer: a dance with the devil. Cancer Cell. 2015 Feb 09; 27(2):156-7.
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Velmurugan GV, Sundaresan NR, Gupta MP, White C. Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes. Cardiovasc Res. 2013 Oct 01; 100(1):143-50.
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Stridh MH, Correa F, Nodin C, Weber SG, Blomstrand F, Nilsson M, Sandberg M. Enhanced glutathione efflux from astrocytes in culture by low extracellular Ca2+ and curcumin. Neurochem Res. 2010 Aug; 35(8):1231-8.
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Schlaeppi K, Bodenhausen N, Buchala A, Mauch F, Reymond P. The glutathione-deficient mutant pad2-1 accumulates lower amounts of glucosinolates and is more susceptible to the insect herbivore Spodoptera littoralis. Plant J. 2008 Sep; 55(5):774-86.
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Kitiphongspattana K, Khan TA, Ishii-Schrade K, Roe MW, Philipson LH, Gaskins HR. Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1543-54.
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Rudin CM, Yang Z, Schumaker LM, VanderWeele DJ, Newkirk K, Egorin MJ, Zuhowski EG, Cullen KJ. Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance. Cancer Res. 2003 Jan 15; 63(2):312-8.
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Doi K, Sawada F, Toda G, Yamachika S, Seto S, Urata Y, Ihara Y, Sakata N, Taniguchi N, Kondo T, Yano K. Alteration of antioxidants during the progression of heart disease in streptozotocin-induced diabetic rats. Free Radic Res. 2001 Mar; 34(3):251-61.
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