Research in the Li lab lies at interface of genetics, gene regulation, and disease. A large part of our work aims to dissect the role of genetic variation on gene regulation at multiple levels. In particular, we develop computational approaches to study genetic effects on gene regulatory mechanisms that have so far been under-appreciated. These include RNA splicing, co-transcriptional dynamics, and post-transcriptional processes. We study how dysregulation of these processes play roles in complex disease. A second focus of the lab is the use of state-of-the-art genomics tools such as single-cell RNA-sequencing to understand cellular composition and function in disease progression.