Timothy Sanders
Title | Assistant Professor |
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Institution | University of Chicago |
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Department | Pediatrics-Neonatology |
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Address | Chicago IL 60637
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Overview My interests are in understanding the mechanisms by which the early embryo and nervous system develop. As an academic Neonatologist with a doctorate in Neurobiology, I provide intensive care for our most fragile children in the Comer Children's NICU as well as have an active research group and laboratory as part of the Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior.
Development throughout embryogenesis and fetal life is accomplished through an array of complex morphogenetic programs. It is the coordinated action of these programs that results in the formation of discrete tissues and organs from unspecified populations of progenitor cells. Despite our numerous advances in understanding early embryonic and fetal life, a more thorough understanding of the underlying molecular and cellular mechanisms involved is essential in the diagnosis and eventual treatment of complex congenital disorders.
Our research program focuses upon the mechanisms that embryologic cell populations employ to pattern and instruct their environment. The experimental paradigms of my work employ classical embryological approaches combined with evolving genetic manipulations to interrogate cell signaling and patterning in real time and at high resolution with advanced imaging techniques.
Biography University of Chicago | PhD | 2001 | Neurobiology | Weill Medical College of Cornell University | MD | 2005 | | Boston Combined Residency Program | | 2007 | Pediatrics | University of California San Francisco | | 2011 | Neonatal-Perinatal Medicine | University of California San Francisco | | 2011 | Cardiovascular Research Institute Fellow |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Wright MC, Logan GJ, Bolock AM, Kubicki AC, Hemphill JA, Sanders TA, Maricich SM. Merkel cells are long-lived cells whose production is stimulated by skin injury. Dev Biol. 2017 02 01; 422(1):4-13. PMID: 27998808.
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Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 17; 10(6):891-899. PMID: 25683712.
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Merkle FT, Fuentealba LC, Sanders TA, Magno L, Kessaris N, Alvarez-Buylla A. Adult neural stem cells in distinct microdomains generate previously unknown interneuron types. Nat Neurosci. 2014 Feb; 17(2):207-14. PMID: 24362763.
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Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS One. 2013; 8(4):e62758. PMID: 23646141.
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Sanders TA, Llagostera E, Barna M. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature. 2013 May 30; 497(7451):628-32. PMID: 23624372.
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Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS One. 2013; 8(2):e56949. PMID: 23437279.
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Park AM, Sanders TA, Maltepe E. Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care. Semin Fetal Neonatal Med. 2010 Aug; 15(4):196-202. PMID: 20599462.
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Domowicz MS, Sanders TA, Ragsdale CW, Schwartz NB. Aggrecan is expressed by embryonic brain glia and regulates astrocyte development. Dev Biol. 2008 Mar 01; 315(1):114-24. PMID: 18207138.
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Sanders TA, Lumsden A, Ragsdale CW. Arcuate plan of chick midbrain development. J Neurosci. 2002 Dec 15; 22(24):10742-50. PMID: 12486167.
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Agarwala S, Sanders TA, Ragsdale CW. Sonic hedgehog control of size and shape in midbrain pattern formation. Science. 2001 Mar 16; 291(5511):2147-50. PMID: 11251119.
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Eide FF, Eisenberg SR, Sanders TA. Electroporation-mediated gene transfer in free-swimming embryonic Xenopus laevis. FEBS Lett. 2000 Dec 01; 486(1):29-32. PMID: 11108837.
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Year | Publications |
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2000 | 1 | 2001 | 1 | 2002 | 1 | 2008 | 1 | 2010 | 1 | 2013 | 4 | 2015 | 1 | 2016 | 1 |
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