"Hedgehog Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intercellular signaling proteins that play an important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.
| Descriptor ID |
D053823
|
| MeSH Number(s) |
D12.644.276.671 D12.776.467.671 D23.529.671
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hedgehog Proteins".
Below are MeSH descriptors whose meaning is more specific than "Hedgehog Proteins".
This graph shows the total number of publications written about "Hedgehog Proteins" by people in this website by year, and whether "Hedgehog Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 5 | 5 |
| 2005 | 0 | 3 | 3 |
| 2006 | 2 | 1 | 3 |
| 2007 | 2 | 1 | 3 |
| 2008 | 0 | 2 | 2 |
| 2009 | 2 | 2 | 4 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 4 | 5 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 3 | 4 |
| 2014 | 3 | 2 | 5 |
| 2015 | 3 | 0 | 3 |
| 2016 | 3 | 4 | 7 |
| 2017 | 2 | 0 | 2 |
| 2018 | 4 | 0 | 4 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 2 | 3 |
| 2021 | 2 | 1 | 3 |
| 2022 | 6 | 2 | 8 |
| 2023 | 1 | 3 | 4 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 2 | 2 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hedgehog Proteins" by people in Profiles.
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Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development. Nat Commun. 2026 Jul 24; 17(1).
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Neuronal Primary Cilia Mediate Noggin Release to Enable Extracellular Signaling. Cells. 2025 10 16; 14(20).
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Novel control for erectile dysfunction research. J Sex Med. 2025 08 04; 22(8):1322-1335.
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Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression. Cancer Discov. 2024 02 08; 14(2):348-361.
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Identification of ancestral gnathostome Gli3 enhancers with activity in mammals. Dev Growth Differ. 2024 Jan; 66(1):75-88.
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Acute and Long-Term Consequences of Co-opted doublesex on the Development of Mimetic Butterfly Color Patterns. Mol Biol Evol. 2023 09 01; 40(9).
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Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer. Cancer Immunol Res. 2023 05 03; 11(5):687-702.
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Ectodermal Wnt signaling, cell fate determination, and polarity of the skate gill arch skeleton. Elife. 2023 03 20; 12.
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Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study. J Clin Oncol. 2023 04 01; 41(10):1921-1932.
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Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis. Dev Dyn. 2023 04; 252(4):483-494.