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Xiaochang Zhang

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentHuman Genetics
AddressChicago IL 60637
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    Collapse Overview 
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    How our brain is developed and evolved remains a major question, and abnormal development of the human brain can cause autism, epilepsy and intellectual disability. We study fundamental mechanisms of brain development and disorders. Our current research includes: mechanisms of cell type specification in mammalian brains, genetics of neurodevelopmental disorders, and roles of mRNA isoforms in neural development and diseases. We develop and apply single-cell approaches, animal models, and functional genomics to address these questions.

    Collapse Biography 
    Collapse education and training
    Boston Children's Hospital and Harvard Medical School, BostonPostdoc/Instructor12/2017Human Genetics
    Fudan University, ShanghaiPhD06/2009Developmental Genetics

    Collapse Research 
    Collapse research activities and funding
    R35GM152177     (ZHANG, XIAOCHANG)Jul 15, 2024 - May 31, 2029
    NIH
    Mechanisms of Cell-type-specific pre-mRNA Splicing
    Role: Principal Investigator
    R01MH130594     (ZHANG, XIAOCHANG)Apr 1, 2023 - Mar 31, 2028
    NIH
    Rescuing SYNGAP1 haploinsufficiency by redirecting alternative splicing
    Role: Principal Investigator
    DP2GM137423     (ZHANG, XIAOCHANG)Sep 30, 2019 - May 31, 2024
    NIH
    Single cell detection of dynamic protein-RNA interaction
    Role: Principal Investigator
    K01MH109747     (ZHANG, XIAOCHANG)Jul 1, 2016 - Mar 31, 2020
    NIH
    Cell Type-specific Alternative Splicing Controls Cerebral Cortical Development
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kang B, Yang Y, Hu K, Ruan X, Liu YL, Lee P, Lee J, Wang J, Zhang X. Infernape uncovers cell type-specific and spatially resolved alternative polyadenylation in the brain. Genome Res. 2023 10; 33(10):1774-1787. PMID: 37907328; PMCID: PMC10691540.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Yang Y, Yang R, Kang B, Qian S, He X, Zhang X. Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons. Cell Rep. 2023 11 28; 42(11):113335. PMID: 37889749; PMCID: PMC10842930.
      Citations: 8     Fields:    Translation:HumansCells
    3. Ruan X, Hu K, Zhang X. PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing. Nat Commun. 2023 06 06; 14(1):3275. PMID: 37280234; PMCID: PMC10244410.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Yang R, Feng X, Arias-Cavieres A, Mitchell RM, Polo A, Hu K, Zhong R, Qi C, Zhang RS, Westneat N, Portillo CA, Nobrega MA, Hansel C, Garcia Iii AJ, Zhang X. Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron. 2023 05 17; 111(10):1637-1650.e5. PMID: 36917980; PMCID: PMC10198817.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    5. Lim ET, Chan Y, Dawes P, Guo X, Erdin S, Tai DJC, Liu S, Reichert JM, Burns MJ, Chan YK, Chiang JJ, Meyer K, Zhang X, Walsh CA, Yankner BA, Raychaudhuri S, Hirschhorn JN, Gusella JF, Talkowski ME, Church GM. Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder. Nat Commun. 2022 06 10; 13(1):3243. PMID: 35688811; PMCID: PMC9187732.
      Citations: 10     Fields:    Translation:HumansCells
    6. Qi C, Feng I, Neil JE, Caluseriu O, Li D, Ganetzky RD, Brasch-Andersen C, Fagerberg C, Bupp C, Muraresku CC, Ruan X, Kang B, Hu K, Zhong R, Bhoj EJ, Hill RS, Falk MJ, Hakonarson H, Kahle KT, Walsh CA, Zhang X, Costa AR, Pinto-Costa R, Hansen LK, Brites P, Sousa MM. Variants in ADD1 cause intellectual disability, corpus callosum dysgenesis, and ventriculomegaly in humans. Genet Med. 2022 02; 24(2):319-331. PMID: 34906466; PMCID: PMC8802223.
      Citations: 6     Fields:    Translation:HumansAnimals
    7. Ruan X, Kang B, Qi C, Lin W, Wang J, Zhang X. Progenitor cell diversity in the developing mouse neocortex. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). PMID: 33649223; PMCID: PMC7958455.
      Citations: 19     Fields:    Translation:AnimalsCells
    8. Coulter ME, Musaev D, DeGennaro EM, Zhang X, Henke K, James KN, Smith RS, Hill RS, Partlow JN, Kamumbu AS, Hatem N, Barkovich AJ, Zaki MS, Sultan T, Rajab A, Al-Gazali L, Mochida GH, Harris MP, Gleeson JG, Walsh CA, Aziza J, Chassaing N, Burglen L. Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival. Genet Med. 2020 06; 22(6):1040-1050. PMID: 32103185; PMCID: PMC7272323.
      Citations: 13     Fields:    Translation:HumansAnimals
    9. Lim ET, Uddin M, De Rubeis S, Chan Y, Kamumbu AS, Zhang X, D'Gama AM, Kim SN, Hill RS, Goldberg AP, Poultney C, Minshew NJ, Kushima I, Aleksic B, Ozaki N, Carracedo A, Kolevzon A, Hultman CM, Weiss LA, Fromer M, Chiocchetti AG, Freitag CM, Autism Sequencing Consortium, Church GM, Scherer SW, Buxbaum JD, Walsh CA, Parellada M, Arango C, Penzol MJ. Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nat Neurosci. 2017 09; 20(9):1217-1224. PMID: 28714951; PMCID: PMC5672813.
      Citations: 144     Fields:    Translation:HumansCells
    10. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25; 166(5):1147-1162.e15. PMID: 27565344; PMCID: PMC5248659.
      Citations: 176     Fields:    Translation:HumansAnimalsCells
    11. Jamuar SS, Lam AT, Kircher M, D'Gama AM, Wang J, Barry BJ, Zhang X, Hill RS, Partlow JN, Rozzo A, Servattalab S, Mehta BK, Topcu M, Amrom D, Andermann E, Dan B, Parrini E, Guerrini R, Scheffer IE, Berkovic SF, Leventer RJ, Shen Y, Wu BL, Barkovich AJ, Sahin M, Chang BS, Bamshad M, Nickerson DA, Shendure J, Poduri A, Yu TW, Walsh CA. Somatic mutations in cerebral cortical malformations. N Engl J Med. 2014 Aug 21; 371(8):733-43. PMID: 25140959; PMCID: PMC4274952.
      Citations: 143     Fields:    Translation:Humans
    12. Zhang X, Ling J, Jing L, Wu J, Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q, Poduri A, Partlow JN, Yu TW, Lam AT, Servattalab S, Rodriguez J, Zon LI, Walsh CA, Barcia G, Ville D, Dulac O, Boddaert N, Munnich A, Colleaux L, Söll D, Nabbout R. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 03; 94(4):547-58. PMID: 24656866; PMCID: PMC3980424.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    13. Zhang X, Zabinsky R, Teng Y, Cui M, Han M. microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):17997-8002. PMID: 22011579; PMCID: PMC3207661.
      Citations: 51     Fields:    Translation:Animals
    14. Zhang X, Han M. Nuclear migration: rock and roll facilitated by dynein and kinesin. Curr Biol. 2010 Dec 07; 20(23):R1027-9. PMID: 21145020.
      Citations: 1     Fields:    Translation:AnimalsCells
    15. Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M. SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009 Oct 29; 64(2):173-87. PMID: 19874786; PMCID: PMC2788510.
      Citations: 259     Fields:    Translation:AnimalsCells
    16. Lei K, Zhang X, Ding X, Guo X, Chen M, Zhu B, Xu T, Zhuang Y, Xu R, Han M. SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009 Jun 23; 106(25):10207-12. PMID: 19509342; PMCID: PMC2700906.
      Citations: 147     Fields:    Translation:AnimalsCells
    17. Zhang X, Xu R, Zhu B, Yang X, Ding X, Duan S, Xu T, Zhuang Y, Han M. Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development. 2007 Mar; 134(5):901-8. PMID: 17267447.
      Citations: 146     Fields:    Translation:AnimalsCells
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