Polypyrimidine Tract-Binding Protein
"Polypyrimidine Tract-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
| Descriptor ID |
D038941
|
| MeSH Number(s) |
D12.776.157.725.829.250 D12.776.664.962.829.250
|
| Concept/Terms |
Polypyrimidine Tract-Binding Protein- Polypyrimidine Tract-Binding Protein
- Polypyrimidine Tract Binding Protein
- Tract-Binding Protein, Polypyrimidine
- p57 Cytoplasmic RNA-Binding Protein
- p57 Cytoplasmic RNA Binding Protein
- PTB Splicing Factor
- Splicing Factor, PTB
- pPTB
- PTB Protein
|
Below are MeSH descriptors whose meaning is more general than "Polypyrimidine Tract-Binding Protein".
Below are MeSH descriptors whose meaning is more specific than "Polypyrimidine Tract-Binding Protein".
This graph shows the total number of publications written about "Polypyrimidine Tract-Binding Protein" by people in this website by year, and whether "Polypyrimidine Tract-Binding Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polypyrimidine Tract-Binding Protein" by people in Profiles.
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Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing. Neuron. 2023 05 17; 111(10):1637-1650.e5.
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RNA-binding protein altered expression and mislocalization in MS. Neurol Neuroimmunol Neuroinflamm. 2020 05; 7(3).
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Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension. Circulation. 2017 12 19; 136(25):2486-2490.
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Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25; 166(5):1147-1162.e15.
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Compositional Control of Phase-Separated Cellular Bodies. Cell. 2016 Jul 28; 166(3):651-663.
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RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts. Genome Res. 2015 Jan; 25(1):1-13.
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Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study. BMC Med Genomics. 2014; 7 Suppl 1:S1.
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Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3. J Virol. 2004 Oct; 78(20):11097-107.
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Cell-specific proteins regulate viral RNA translation and virus-induced disease. EMBO J. 2001 Dec 03; 20(23):6899-908.